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Antibiotics
Special Issues
Challenges and Strategies for the Antibiotic Resistance Crisis
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Challenges and Strategies for the Antibiotic Resistance Crisis

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 January 2026 | Viewed by 2225

Special Issue Editors

Dr. Manuel Simões

grade E-Mail Website
Guest Editor
LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Roberto Frias, s/n, 4200-465 Porto, Portugal
Interests: antimicrobial agents; emerging antimicrobial strategies; antimicrobial resistance; biofilms; plant secondary metabolites
Special Issues, Collections and Topics in MDPI journals
Dr. Marc Maresca

E-Mail Website
Guest Editor
CNRS, Aix-Marseille University, Centrale Marseille, iSm2, 13013 Marseille, France
Interests: mycotoxins; fungal metabolites; antimicrobial; anticancer; antinflammatory; antioxidant
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is compiled in cooperation with the 4th International Electronic Conference on Antibiotics, organized by Antibiotics from 21 to 23 May 2025 on the MDPI Sciforum platform (https://sciforum.net/event/ECA2025). We welcome submissions from the scientific community and stakeholders to present and discuss recent advances in antibiotic research.

The following areas were covered:

  • Antibiotics Stewardship and Antimicrobial Use in Healthcare Settings;
  • Antibiotics and One Health;
  • Epidemiology, Prevalence and Mechanisms of Antibiotics Resistance and Cross-Resistance;
  • Novel Antimicrobial Agents: Discovery, Design, Synthesis and Action;
  • Multidisciplinary Antimicrobial Strategies: Materials, Peptides, Bacteriophages and Repurposing;
  • Antibiotic Clinical Studies, Pharmacokinetics and Pharmacodynamics;
  • Clinical and Environmental Impact of Bacterial Biofilms;
  • Artificial Intelligence Strategies to Tackle Antibiotic Resistance.

Dr. Manuel Simões
Dr. Marc Maresca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibiotics stewardship
  • antimicrobial use
  • antibiotics resistance
  • novel antimicrobial agents
  • multidisciplinary antimicrobial strategies
  • antibiotic clinical studies
  • artificial intelligence strategies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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24 pages, 4295 KB  
Article
Genomic Profiling Reveals Clinically Relevant Antimicrobial Resistance and Virulence Genes in Klebsiella pneumoniae from Hong Kong Wet Markets
by Wing Yui Ngan, Subramanya Rao, Aster Hei Yiu Fung and Olivier Habimana
Antibiotics 2025, 14(9), 922; https://doi.org/10.3390/antibiotics14090922 - 12 Sep 2025
Abstract
Background:Klebsiella pneumoniae is a highly dangerous microorganism that presents significant challenges to effectively eliminate in food production facilities, making it a serious and urgent public health concern. The wet markets of Hong Kong represent a considerable yet insufficiently explored source for the [...] Read more.
Background:Klebsiella pneumoniae is a highly dangerous microorganism that presents significant challenges to effectively eliminate in food production facilities, making it a serious and urgent public health concern. The wet markets of Hong Kong represent a considerable yet insufficiently explored source for the spread of microorganisms. Methods: This investigation employed whole-genome sequencing and comparative genomics to assess the genomic variation and adaptive traits of K. pneumoniae extracted from wooden cutting boards in these marketplaces. We examined four wet market isolates in conjunction with 39 publicly accessible genomes from diverse origins. Results: Pan-genome analysis revealed a diverse and open genetic structure significantly shaped by horizontal gene transfer. Phylogenetic reconstruction did not categorize the wet market isolates into a singular clade, indicating varied contamination sources; nonetheless, certain market isolates exhibited close phylogenetic affiliations with high-risk clinical clones, implying possible spillover events. These isolates exhibited a concerning variety of antimicrobial resistance genes (ARGs), chiefly encoding efflux pumps (acrAB, oqxAB), which confer resistance to numerous drug categories. Moreover, the evaluation for pathogenicity attributes uncovered genes associated with robust biofilm development (fim and mrk operons) and efficient iron procurement strategies. Conclusions: The existence of these genetically adaptable isolates, possessing multidrug resistance and virulence factors, renders wet markets potential amplifiers and reservoirs for the spread of resistant pathogens. These findings present the initial genomic evidence of such risks in Hong Kong’s wet markets and emphasize the immediate necessity for improved hygiene protocols and comprehensive One Health surveillance to reduce transmission at the human–animal–environment interface. Full article
(This article belongs to the Special Issue Challenges and Strategies for the Antibiotic Resistance Crisis)
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22 pages, 5608 KB  
Article
1,5-Diarylidene-4-Piperidones as Promising Antifungal Candidates Against Cryptococcus neoformans
by Elise Courvoisier-Dezord, Hugo Ragusa, Axelle Grandé, Louise Denudt, Yolande Charmasson, Frédéric Dumur, Didier Siri, Marc Maresca and Malek Nechab
Antibiotics 2025, 14(9), 883; https://doi.org/10.3390/antibiotics14090883 - 1 Sep 2025
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Abstract
Background/Objectives: The present study investigates the antifungal potential of 1,5-diarylidene-4-piperidones. Methods: These compounds were synthesized via Claisen–Schmidt condensation, and their antifungal efficacy was tested against Cryptococcus neoformans, a yeast recently qualified as a critical priority pathogen by the World Health Organization, through [...] Read more.
Background/Objectives: The present study investigates the antifungal potential of 1,5-diarylidene-4-piperidones. Methods: These compounds were synthesized via Claisen–Schmidt condensation, and their antifungal efficacy was tested against Cryptococcus neoformans, a yeast recently qualified as a critical priority pathogen by the World Health Organization, through determination of their minimum inhibitory concentration (MIC). We designed and synthesized a series of piperidones to explore structure–activity relationships. Results: Systematic modification of the substituent pattern revealed that tetrabutoxy groups exhibited potent activity (MIC of 7.8 µM), surpassing standard antifungals like fluconazole. The selectivity index (SI) values confirmed their safety profile across various human cells. Docking analysis demonstrated that these compounds target sterol 14-demethylase, suggesting potential inhibition of ergosterol synthesis as a mechanism of action. Interestingly, the compounds also demonstrated broad-spectrum activity against other pathogenic yeasts and fungi, including Candida and Aspergillus species, and against fluconazole-resistant strains. Conclusions: These findings underscore the potential of 1,5-diarylidene-4-piperidones as promising antifungal candidates with a favorable safety profile. Full article
(This article belongs to the Special Issue Challenges and Strategies for the Antibiotic Resistance Crisis)
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Review

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26 pages, 2915 KB  
Review
Recent Knowledge in the Application of Saccharomyces cerevisiae in Aquaculture: A Bibliometric and Narrative Review
by Elshafia Ali Hamid Mohammed, Béla Kovács and Károly Pál
Antibiotics 2025, 14(8), 736; https://doi.org/10.3390/antibiotics14080736 - 22 Jul 2025
Viewed by 981
Abstract
Aquaculture is a key food production sector responsible for meeting the nutritional needs of a rapidly growing global population. However, the emergence of disease outbreaks has become a major challenge for the aquaculture industry, resulting in significant economic losses. The use of costly [...] Read more.
Aquaculture is a key food production sector responsible for meeting the nutritional needs of a rapidly growing global population. However, the emergence of disease outbreaks has become a major challenge for the aquaculture industry, resulting in significant economic losses. The use of costly and toxic antibiotics for treatment has a negative impact on the aquatic environment. Consequently, there has been a growing interest in probiotics as a non-antibiotic approach to manage disease outbreaks and improve fish performance. The use of the yeast Saccharomyces cerevisiae (SC) has shown remarkable benefits in aquaculture. In February 2025, a systematic search was conducted based on the Web of Science (WoS) database for the period 2015–2025 to identify relevant studies investigating the beneficial effects of SC in aquaculture. After searching on WoS, 466 documents were found and analyzed using R-bibliometric package for comprehensive analysis to identify research gap, trends, and distribution of global literature that focuses on SC in aquaculture. The most relevant and recent articles were reviewed, summarized and discussed. The yeast SC have shown a wide range of benefits, including improved growth performance, feed efficiency, enhanced diversity of the gut microbiome and immune response. The implementation of SC is becoming a recent trend and its efficacy in aquatic environments has been thoroughly investigated. This review aims to provide a valuable insight into SC as one of the most important aquaculture probiotics. It also emphasizes the need for further research to fully understand its benefits and the way it works. Full article
(This article belongs to the Special Issue Challenges and Strategies for the Antibiotic Resistance Crisis)
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