Journal Description
Membranes
Membranes
is an international, peer-reviewed, open access journal covering the broad aspects of the science and technology of both biological and non-biological membranes, published monthly online by MDPI. The Membrane Society of Australasia (MSA) and Polish Membrane Society (PTMem) are affiliated with Membranes and their members receive discounts on the article processing charges.
- Open Access— free for readers, with article processing charges (APC) paid by authors or their institutions.
- High Visibility: indexed within Scopus, SCIE (Web of Science), Ei Compendex, PubMed, PMC, CAPlus / SciFinder, Inspec, and other databases.
- Journal Rank: JCR - Q2 (Polymer Science) / CiteScore - Q1 (Chemical Engineering (miscellaneous))
- Rapid Publication: manuscripts are peer-reviewed and a first decision is provided to authors approximately 14.9 days after submission; acceptance to publication is undertaken in 7.9 days (median values for papers published in this journal in the first half of 2026).
- Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.
- Journal Cluster of Polymer and Macromolecular Science: Polymers, Membranes, Gels, Polysaccharides, Textiles, Macromol, Microplastics and Adhesives.
Impact Factor:
4.2 (2025);
5-Year Impact Factor:
4.3 (2025)
Latest Articles
Comparative Numerical Evaluation of Feed-Spacer Geometries in Reverse Osmosis Modules for Enhanced Water Treatment Sustainability
Membranes 2026, 16(8), 265; https://doi.org/10.3390/membranes16080265 - 10 Aug 2026
Abstract
The lack of freshwater in the world requires a paradigm shift from linear water consumption to resilient and low-energy desalination technologies. Although reverse osmosis (RO) is the standard in the industry, its usefulness is essentially constrained by concentration polarization (CP) and non-useful hydraulic
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The lack of freshwater in the world requires a paradigm shift from linear water consumption to resilient and low-energy desalination technologies. Although reverse osmosis (RO) is the standard in the industry, its usefulness is essentially constrained by concentration polarization (CP) and non-useful hydraulic pressure losses. This paper applies a high-fidelity computational model in ANSYS Fluent 2022 R1 to conduct a comparative parametric evaluation of hexagonal and sinusoidal feed-spacer geometries relative to a baseline grid configuration. The solute concentration gradients at the fluid–membrane interface were solved using a 3D species transport model, which was optimized using one-micron near-wall inflation layers. The hexagonal configuration produced the lowest maximum membrane-surface salt mass fraction, decreasing it from 0.1127 kg/kg for the baseline grid to 0.0429 kg/kg, corresponding to a 61.9% reduction. Although the hexagonal design required an inlet pressure of 205.7 Pa, it produced a more favorable normalized mass-transfer–friction trade-off than the sinusoidal configuration (447.8 Pa), with a System Performance Index (η) of 2.53. These results demonstrate comparative micro-scale improvements in concentration polarization control and hydraulic performance under the simulated conditions. Experimental testing and system-level modeling are required before conclusions can be drawn regarding full-module energy consumption, photovoltaic integration, long-term fouling behavior, or economic feasibility. This study is consistent with the emerging Concepts and design for sustainability, whereby a circular and energy-efficient water economy is facilitated through an innovative mechanical design.
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(This article belongs to the Section Membrane Applications for Water Treatment)
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Open AccessArticle
Charged Functional Groups Drive Nanofiltration Li+/Mg2+ Selectivity
by
Suwei Liu, Jiaxuan Wang, Sinan Keten and Richard M. Lueptow
Membranes 2026, 16(8), 264; https://doi.org/10.3390/membranes16080264 - 10 Aug 2026
Abstract
Polyamide nanofiltration (NF) membranes offer a scalable and energy-efficient pathway for lithium concentration from lake brines and battery leachates, but practical implementation hinges on achieving high selectivity of Li+ over Mg2+. The active layer of these membranes can be positively
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Polyamide nanofiltration (NF) membranes offer a scalable and energy-efficient pathway for lithium concentration from lake brines and battery leachates, but practical implementation hinges on achieving high selectivity of Li+ over Mg2+. The active layer of these membranes can be positively or negatively charged, carrying both amine groups that can be protonated and carboxyl groups that can be deprotonated with an ionization state that is set by the feed pH. Here, molecular dynamics simulations are used to elucidate how pH-dependent charged functional groups within the polymeric nanostructure of NF membranes govern Li+/Mg2+ selectivity, arising from electrostatic charge interactions between ions and functional groups at the molecular scale as well as steric size exclusion within the membrane pore structure. Although single-salt Li+ or Mg2+ feed solutions exhibit similar ion penetration behavior, mixed Li+/Mg2+ feeds show markedly enhanced Li+/Mg2+ selectivity at low concentrations when the membrane is positively charged. This selectivity arises because Mg2+ interacts more strongly than Li+ with repulsive protonated amine (NH2+) groups, suppressing divalent ion transport, an effect that emerges specifically when the two cations compete for the same ions in a mixed feed. In contrast, for negatively charged membranes, attractive interactions with deprotonated carboxylate ( ) groups strongly hinder the transport of both ions, resulting in poor selectivity. Ion clustering within membrane pores further reduces transport through steric effects. These results provide molecular-level insight into how charged functional groups control mono/divalent ion selectivity when competing ions are present and highlight positively charged membranes as optimal platforms for lithium separation applications.
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(This article belongs to the Special Issue Membrane Applications for Molecular Purification)
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Electrochemically Driven Microbial Anode-Membrane Capacitor Deionization System: Energy Consumption Analysis for Enhancing NaCl Removal and Desalination at Different Gradients
by
Wenlong Liu and Jun Pan
Membranes 2026, 16(8), 263; https://doi.org/10.3390/membranes16080263 - 7 Aug 2026
Abstract
To overcome the limitations of insufficient driving force in traditional microbial desalination batteries, this paper constructs a microbial anode-membrane capacitive deionization (B-MCDI) coupling system. For the first time, direct coupling between extracellular electron transfer in Shewanella oneidensis and double-layer adsorption at the MCDI
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To overcome the limitations of insufficient driving force in traditional microbial desalination batteries, this paper constructs a microbial anode-membrane capacitive deionization (B-MCDI) coupling system. For the first time, direct coupling between extracellular electron transfer in Shewanella oneidensis and double-layer adsorption at the MCDI cathode is achieved at the circuit and material levels, realizing self-driven, low-energy desalination. High-specific-surface-area carbon felt is used as the anode, and a stable electrogenic biomembrane (output voltage >400 mV) is formed after directional domestication with Shewanella oneidensis MR-1. Activated carbon is used as the cathode to construct the MCDI electrode. In the three-chamber reactor, the desalination chambers are separated by cation and anion exchange membranes. Under the drive of the bioelectric field, Na+ and Cl− selectively permeate into the cathode and anode chambers, respectively, effectively suppressing the co-ion effect. Under optimal operating conditions (external resistance 1000 Ω, initial NaCl concentration 2.0 g/L), the system achieved a cumulative desalination rate of 85.1% after 12 h of operation, with a salt adsorption capacity of 162.1 mg/g, an average desalination rate of 13.51 mg/(g·h), and an energy consumption of only 0.58 kWh/m3. This demonstrates that bioelectric energy can effectively provide targeted power to drive capacitive adsorption and desalination. Under initial NaCl concentrations of 1.0 g/L and 3.0 g/L, the highest desalination rates reached 78% and 68%, respectively. The maximum instantaneous desalination rate occurred within 0.5–1.0 h (64 mg/h under 2.0 g/L conditions), exhibiting a three-stage kinetic characteristic of “fast-slow-equilibrium”. The energy consumption in this study was only 0.51 kWh/m3, further demonstrating the high energy efficiency of bioelectrically coupled MCDI in low-salinity treatment areas. Therefore, this B-MCDI can serve as a theoretically feasible proof-of-concept technology for desalination of brackish water that meets the requirements of self-driven, low-energy consumption, and has promising applications in decentralized water supply systems in areas with limited energy supply or no available electricity.
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(This article belongs to the Special Issue Electrochemical Membrane and Membrane Processes)
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Open AccessEditorial
Advanced Membrane Technologies for the Treatment of Industrial Wastewater and Emerging Contaminants: Challenges and Innovations
by
Mohammed J. K. Bashir and Choon Aun Ng
Membranes 2026, 16(8), 262; https://doi.org/10.3390/membranes16080262 - 5 Aug 2026
Abstract
Industrial wastewater management has become one of the defining environmental challenges of the twenty-first century [...]
Full article
(This article belongs to the Special Issue Advanced Membrane Technologies for the Treatment of Industrial Wastewater and Emerging Contaminants: Challenges and Innovations)
Open AccessArticle
Multifractal Analysis of Ion-Channel Currents: A Comparative Study of the WTMM and MFDFA Approaches
by
Janusz Miśkiewicz, Zbigniew Burdach, Agnieszka Siemieniuk and Waldemar Karcz
Membranes 2026, 16(8), 261; https://doi.org/10.3390/membranes16080261 - 4 Aug 2026
Abstract
The multifractal properties of ion-channel currents recorded from Beta vulgaris L. vacuoles were analyzed using multifractal detrended fluctuation analysis (MFDFA) and the Wavelet Transform Modulus Maxima (WTMM) method. The study covered a range of membrane potentials, different incubation times with indole-3-acetic acid (IAA),
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The multifractal properties of ion-channel currents recorded from Beta vulgaris L. vacuoles were analyzed using multifractal detrended fluctuation analysis (MFDFA) and the Wavelet Transform Modulus Maxima (WTMM) method. The study covered a range of membrane potentials, different incubation times with indole-3-acetic acid (IAA), and regimes with single and multiple active channels. Clear multifractal behavior was observed, with the spectrum width, , varying with voltage, biochemical modulation, and channel occupancy. A comparative analysis shows that WTMM provides a more reliable and detailed characterization of the scaling properties. In particular, WTMM yields stronger nonlinearity in the scaling exponents , clearer scaling regimes, and higher sensitivity to variations in , whereas MFDFA results are affected by deviations from ideal scaling. The presence of multiple channels introduces a structured, non-monotonic dependence of on voltage, indicating collective dynamics. These results demonstrate that WTMM is better suited for analyzing nonstationary, dichotomous ion-channel signals.
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(This article belongs to the Section Biological Membranes)
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Promotion Effect of Steam on Hydrogen and Oxygen Separation in Electrochemical Membrane Reactor: Investigation Under the Aromatization Reaction Temperature Window
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Lihui Wang, Shao Zhang, Mingming Wang, Zhigang Wang and Xiaoyao Tan
Membranes 2026, 16(8), 260; https://doi.org/10.3390/membranes16080260 - 31 Jul 2026
Abstract
Methane aromatization mainly proceeds at 650–750 °C. Simultaneous separation of hydrogen and oxygen can boost conversion efficiency and mitigate catalyst coking, yet most non-electrochemical membrane reactors fail to achieve synchronous hydrogen–oxygen separation within this temperature range. Accordingly, an electrochemical membrane reactor is adopted
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Methane aromatization mainly proceeds at 650–750 °C. Simultaneous separation of hydrogen and oxygen can boost conversion efficiency and mitigate catalyst coking, yet most non-electrochemical membrane reactors fail to achieve synchronous hydrogen–oxygen separation within this temperature range. Accordingly, an electrochemical membrane reactor is adopted in this work, and steam is introduced to improve gas separation efficiency. BZCY hollow fiber membranes with mixed proton and oxygen ion conductivity are selected as the research material, and the influences of three distinct steam feeding modes (anode side only, cathode side only, simultaneous feeding on both sides) on H2 and O2 permeation and separation are systematically investigated. Experimental results reveal that steam humidification significantly enhances the permeation fluxes of hydrogen and oxygen. Notably, such promotional effect strongly depends on the steam feeding location. At 700 °C and 1.5 V, the hydrogen permeation flux increases to 1.469 mL⋅min−1⋅cm−2, in sharp contrast to 0.189 mL⋅min−1⋅cm−2 under dry atmosphere. Meanwhile, the oxygen permeation flux reaches 0.824 mL⋅min−1⋅cm−2 at 700 °C with steam, which is approximately four times that under dry conditions. This study verifies the intrinsic H2 and O2 permeation capability of electrochemical membrane reactors and the remarkable promotion effect originating from steam, facilitating further practical applications of such membrane reactors in methane aromatization.
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(This article belongs to the Section Membrane Applications for Gas Separation)
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Numerical Study of Concentration Polarization in Electrodialysis for High-Salinity Solution Concentration in Air-Conditioning Systems
by
Bo Sun and Ning Lyu
Membranes 2026, 16(8), 259; https://doi.org/10.3390/membranes16080259 - 29 Jul 2026
Abstract
Concentration polarization is a common phenomenon in membrane separation processes and generally impairs mass transfer efficiency. Electrodialysis (ED) is considered a promising technology for concentrating high-salinity solutions used in air-conditioning systems; however, concentration polarization under high-concentration operating conditions remains insufficiently understood. In this
[...] Read more.
Concentration polarization is a common phenomenon in membrane separation processes and generally impairs mass transfer efficiency. Electrodialysis (ED) is considered a promising technology for concentrating high-salinity solutions used in air-conditioning systems; however, concentration polarization under high-concentration operating conditions remains insufficiently understood. In this study, a numerical framework combining a simplified model and a coupled transport model was developed to characterize concentration distributions within an ED concentrate channel. The effects of flow velocity, current density, and feed concentration on concentration profiles were systematically investigated. The results show that transmembrane water transport plays an important role in concentration polarization, and neglecting this effect leads to significant overestimation of ion concentration near the membrane surface. Although ion concentration increases markedly in the vicinity of the ion-exchange membranes, it remains nearly constant in the bulk region along the flow direction. Based on this non-uniform concentration distribution, a conceptual ED configuration with separated flow channels was proposed and evaluated. The results indicate that selectively extracting the enriched boundary-layer region can enhance the outlet concentration of the product stream, whereas increasing the intermediate channel width reduces volumetric yield, revealing a clear trade-off between concentration enhancement and production capacity.
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(This article belongs to the Special Issue Membranes for Electrochemical Energy and Related Systems)
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Open AccessReview
MBenes for Advanced Water Treatment and Desalination Membranes: A Bibliometric, Materials Engineering, and Future Perspectives Review
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Asam Amin Almulla and Fikri T. Dweiri
Membranes 2026, 16(8), 258; https://doi.org/10.3390/membranes16080258 - 28 Jul 2026
Abstract
Water scarcity and rising demand for safe water continue to motivate the development of improved treatment and desalination membranes. MBenes are an emerging family of two-dimensional transition-metal borides derived from layered MAB phases. Material-level experiments and computational studies indicate potentially useful electronic, structural,
[...] Read more.
Water scarcity and rising demand for safe water continue to motivate the development of improved treatment and desalination membranes. MBenes are an emerging family of two-dimensional transition-metal borides derived from layered MAB phases. Material-level experiments and computational studies indicate potentially useful electronic, structural, and surface properties; however, direct evidence for MBene membranes remains limited. This review combines an author-generated bibliometric analysis of 279 Scopus-indexed records, retrieved on 14 April 2026, with a critical assessment of MBene synthesis, properties, and prospective membrane applications. Evidence from graphene, graphene oxide, transition-metal dichalcogenides, and MXenes is treated as analogous evidence rather than direct validation of MBene membrane performance. The analysis shows that MBene research is concentrated mainly in synthesis, computational modeling, catalysis, and energy storage, whereas experimentally validated water-treatment and desalination membranes are scarce. Priorities include reproducible MBene synthesis, controlled membrane fabrication, standardized performance testing, long-term stability and leaching assessment, and pilot-scale and techno-economic evaluation.
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(This article belongs to the Special Issue Advanced Membrane Technologies for Hypersaline Wastewater, Groundwater, and Seawater Desalination)
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Open AccessArticle
Auditable Clean-in-Place Decision Support from Routine SWRO SCADA: Selecting Differential-Pressure Recovery and Falsifying a Per-CIP-Reset Trigger
by
Yi Hsiang Su, Fan Cheng Meng and Pieh Yu Chang
Membranes 2026, 16(8), 257; https://doi.org/10.3390/membranes16080257 - 28 Jul 2026
Abstract
Reverse osmosis (RO) desalination operators time membrane clean-in-place (CIP) by non-site-calibrated vendor thresholds. We present an auditable workflow that converts these thresholds into plant-calibrated decision support. It pre-specifies the recovery target and analysis unit, compares candidate signals with a five-test label-free battery, and
[...] Read more.
Reverse osmosis (RO) desalination operators time membrane clean-in-place (CIP) by non-site-calibrated vendor thresholds. We present an auditable workflow that converts these thresholds into plant-calibrated decision support. It pre-specifies the recovery target and analysis unit, compares candidate signals with a five-test label-free battery, and reports composite weights only when identifiable. Using ≈two years of routine 10 min SCADA from one three-train island seawater RO plant (≈600 m3 d−1), the battery selects normalised feed channel differential pressure (DP_norm) for site-specific cleaning-recovery review. On the false discovery rate (FDR)-effective unit (n = 14 campaigns), recovery is marginal and not FDR-significant (mid-p Benjamini–Hochberg q ≈ 0.141); DP_norm is therefore an operator-review signal, not an autonomous or FDR-confirmed trigger. The same battery invalidates a per-CIP-reset net driving pressure trigger as a clip-floor regression-to-the-mean artefact; it collapses under the pre-specified matched placebo and is reproduced by a fake-date null, a finding that is bounded to this plant and estimand, and not causal proof of a unique mechanism. The DP_norm of ≥1.20 review point is an exploratory, in-sample heuristic selected partly against the endogenous operator log, and its indexed economic comparison inherits that limitation. An identifiability-gated Bayesian power prior leaves the four-weight composite non-identifiable on this single-regime plant, pinning only the near-zero salt passage weight. The contribution is a bounded, estimand-based workflow that supports audit without replacing operators or the safety envelope.
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(This article belongs to the Special Issue New Challenges in Membrane Technology for Desalination)
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Open AccessArticle
Hybrid Response Surface–Particle Swarm Optimisation of Donnan Dialysis Processes for Aluminium Recovery from Water Treatment Sludge
by
James Darmey, Sudesh Rathilal, Emmanuel Kweinor Tetteh and Julius Cudjoe Ahiekpor
Membranes 2026, 16(8), 256; https://doi.org/10.3390/membranes16080256 - 27 Jul 2026
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Sustainable recovery of aluminium from water treatment plant sludge (WTPS) offers a promising route for resource valorisation and waste reduction. In this study, Donnan dialysis (DD) is evaluated as a separation technique for recovering aluminium from a synthetic hydroxide-based feed simulating WTPS. A
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Sustainable recovery of aluminium from water treatment plant sludge (WTPS) offers a promising route for resource valorisation and waste reduction. In this study, Donnan dialysis (DD) is evaluated as a separation technique for recovering aluminium from a synthetic hydroxide-based feed simulating WTPS. A Box–Behnken design coupled with response surface methodology (BBD–RSM) was employed to model and quantify the effects of key operating parameters, namely feed pH, flow rate, initial aluminium concentration, runtime, and sweep solution concentration. Particle Swarm Optimisation (PSO) was integrated with the RSM framework to enhance global optimisation. The PSO approach predicted a maximum aluminium recovery of 99.1% under optimal conditions (pH 4.74, flow rate 98.60%, feed concentration 1313.3 ppm, runtime 21.5 h, and sweep concentration 0.25 M). Experimental validation yielded a recovery efficiency of 90.4%, corresponding to a deviation of 9.2% at a 95% confidence level with R2 = 0.9632 and predicted R2 = 0.9072. The results demonstrate that DD is an effective and scalable approach for recovering aluminium from hydroxide-rich sludge matrices, while PSO provides a robust optimisation strategy to address the nonlinearities inherent in membrane-based separation processes. This hybrid modelling framework advances process optimisation methodologies and supports the development of sustainable sludge-to-resource technologies in water treatment systems.
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Open AccessReview
Research Status of Metal–Organic Frameworks in Field of Membrane Distillation
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Shuhua Ma, Quanxing Liao, Shiai Xu, Guanglan Che, Haoyi Chen and Juan Li
Membranes 2026, 16(8), 255; https://doi.org/10.3390/membranes16080255 - 27 Jul 2026
Abstract
Membrane distillation (MD) technology has become an effective solution to freshwater scarcity due to its low energy consumption, high separation efficiency, and ability to handle highly concentrated saline wastewater. Nevertheless, issues such as membrane wetting, membrane fouling, and low membrane flux severely limit
[...] Read more.
Membrane distillation (MD) technology has become an effective solution to freshwater scarcity due to its low energy consumption, high separation efficiency, and ability to handle highly concentrated saline wastewater. Nevertheless, issues such as membrane wetting, membrane fouling, and low membrane flux severely limit its large-scale application. Composite membranes prepared using metal–organic framework (MOF) materials as fillers have become a research hotspot due to their advantages, such as permeable microporous channels, customizable pore structures, and modifiable active sites. These properties enable them to effectively reduce temperature polarization and concentration polarization phenomena. This article describes the characteristics of MOF materials and their current applications in the field of MD, with a comparative analysis of the applicability of MOF polycrystalline membranes and MOF composite membranes in MD, and discusses the working principle of MOFs in enhancing the performance of MD. Finally, the problems and challenges associated with the use of MOFs in MD applications are analyzed. This study aims to provide theoretical guidance for the application of MOF materials in the field of MD seawater desalination.
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(This article belongs to the Special Issue Metal-Organic Framework-Based Membranes for Applications in Molecular Separation)
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Open AccessArticle
Tuning the Permeability–Selectivity Trade-Off in Activated Carbon/PES Mixed Matrix Membranes via Compaction and Vapor-Induced Phase Separation
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Asseghaf Bintang Ramadhani, Jason Nathanael Thionardo, Muhammad Mirza Rahardianto, Annas Zakky Firmansyah, Kartika Nur ‘Anisa’, Chandrawati Putri Wulandari, Muslim Mahardika, Yudan Whulanza, Ario Sunar Baskoro, Thanongsak Thepsonthi, Nor Hasrul Akhmal Ngadiman and Gunawan Setia Prihandana
Membranes 2026, 16(8), 254; https://doi.org/10.3390/membranes16080254 - 25 Jul 2026
Abstract
This study investigates the synergistic effects of compaction pressure and vapor-induced phase separation (VIPS) on the morphological, mechanical, and initial filtration properties of activated carbon/polyethersulfone composite block membranes. Membranes were fabricated using varying compaction pressures (5 and 10 kg/cm2) and VIPS
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This study investigates the synergistic effects of compaction pressure and vapor-induced phase separation (VIPS) on the morphological, mechanical, and initial filtration properties of activated carbon/polyethersulfone composite block membranes. Membranes were fabricated using varying compaction pressures (5 and 10 kg/cm2) and VIPS exposure times (0 and 10 min) prior to direct non-solvent-induced phase separation (NIPS). Surface wettability analysis revealed that the optimized 50 wt.% activated carbon configurations were superhydrophilic (0° water contact angle), exhibiting instantaneous fluid absorption driven by strong capillary forces within the highly hygroscopic matrix. Morphological and gravimetric evaluations demonstrated that minimizing compaction (5 kg/cm2) and bypassing VIPS generated large macrovoids, resulting in the highest bulk internal porosity (61.05%) and maximum continuous gravity-driven water flux. Conversely, incorporating a 10-min VIPS exposure shifted the internal structure toward an interconnected sponge-like network. This structural transformation yielded the highest bovine serum albumin (BSA) rejection rate (12.97%) when paired with low pressure, as the network extended fluid residence time and maximized exposure to the activated carbon adsorption sites. Applying high compaction pressure (10 kg/cm2) to VIPS-treated membranes induced excessive polymer encapsulation of the active particles, significantly reducing separation efficiency while concurrently maximizing initial uniaxial tensile strength. Ultimately, these findings establish a foundational and highly tunable framework, demonstrating that calibrating mechanical compression alongside phase inversion dynamics balances permeability, adsorptive selectivity, and inter-particle binding cohesion for composite block membranes.
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(This article belongs to the Special Issue Design and Formation of Polymer Composite Membrane Material)
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Open AccessArticle
Separation of Taurine and Sodium Sulfate from Simulated Mother Liquor by Electrodialysis and Process Optimization
by
Huiting Zhu, Douyan Cao and Jigang Zhao
Membranes 2026, 16(8), 253; https://doi.org/10.3390/membranes16080253 - 23 Jul 2026
Abstract
To address the high energy demand and product losses associated with separating taurine from sodium sulfate (Na2SO4) in the ethylene oxide route to taurine, electrodialytic desalination of a simulated taurine/Na2SO4 mother liquor was investigated. The effects
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To address the high energy demand and product losses associated with separating taurine from sodium sulfate (Na2SO4) in the ethylene oxide route to taurine, electrodialytic desalination of a simulated taurine/Na2SO4 mother liquor was investigated. The effects of applied voltage, circulation flow rate, and initial feed concentration on the desalination rate, product purity, taurine recovery, current efficiency, specific energy consumption, and membrane productivity were evaluated. Ion-transport behavior was further examined using COMSOL Multiphysics® 6.3. At 14 V, a circulation flow rate of 200 L/h, and initial taurine and Na2SO4 concentrations of 100 and 68 g/L, respectively, the process achieved a taurine purity of 99.8% and a recovery of 98.9%. The specific electrical energy consumption of the electrodialysis unit was 0.56 kWh/kg Na2SO4, and the membrane productivity was 0.49 kg Na2SO4/(m2·h). One of the key findings of this work is that the low-salt stage plays a dominant role in process economics. This observation led to a simple endpoint-control strategy. The ED operation is stopped when the Na2SO4 concentration in the dilute compartment drops to about 2 g/L. This avoids prolonged operation under inefficient conditions and reduces ED energy consumption by 16.5%. Within the binary simulated system and the defined cost boundary, the proposed process provided a higher taurine recovery and a lower estimated separation cost than the conventional crystallization route. These results demonstrate the laboratory-scale feasibility of electrodialysis for desalting simulated taurine mother liquor.
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(This article belongs to the Special Issue Electrodialysis and Novel Electro-Membrane Processes)
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Open AccessArticle
Functional In Vitro Expression of the Succinate–Acetate Transporter SatP and an Initial Screening Strategy
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Yuelang Yao, Bernhard Schuster, Karola Vorauer-Uhl and Diethard Mattanovich
Membranes 2026, 16(8), 252; https://doi.org/10.3390/membranes16080252 - 23 Jul 2026
Abstract
In vitro protein expression has gained considerable attention due to its experimental flexibility and time efficiency. This method employs essential transcriptional components and is particularly advantageous for expressing proteins that are challenging to produce in living systems, such as membrane or toxic proteins.
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In vitro protein expression has gained considerable attention due to its experimental flexibility and time efficiency. This method employs essential transcriptional components and is particularly advantageous for expressing proteins that are challenging to produce in living systems, such as membrane or toxic proteins. Membrane acetate transporters regulate cellular acetate levels and are important for microbial engineering in industrial fermentation processes. In this study, the succinate–acetate transporter protein SatP from Escherichia coli was functionally expressed utilizing a cell-free system and subsequently characterized through single-channel recordings. Beyond confirming its transport activities, we identified malate and fumarate as additional potential substrates of SatP. The successful in vitro expression of SatP lays the foundation for cell-free screening of acetate transporters. We then further investigated a preliminary screening assay and proposed a potential strategy for the rapid expression and functional characterization of acetate transport proteins. Because acetate accumulation can inhibit microbial growth and reduce fermentation efficiency, a better understanding of SatP-mediated acetate transport may facilitate the engineering of microbial strains with enhanced acetate tolerance and improved product yields. This knowledge provides a foundation for the rational optimization of industrial fermentation processes.
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(This article belongs to the Section Biological Membranes)
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Open AccessArticle
Membrane-Based Decolourisation and Purification of Starch Hydrolysates: A Systematic UF–NF Screening Study
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Camila Cabeza, Amal El Gohary Ahmed and Michael Harasek
Membranes 2026, 16(7), 251; https://doi.org/10.3390/membranes16070251 - 22 Jul 2026
Abstract
Membrane-based processes offer promising sustainable alternatives for the decolourisation and purification of starch hydrolysates, yet membrane selection and operating conditions remain the most critical challenges. This study systematically evaluates the performance of polymeric ultrafiltration (UF) and nanofiltration (NF) membranes for starch hydrolysate syrup
[...] Read more.
Membrane-based processes offer promising sustainable alternatives for the decolourisation and purification of starch hydrolysates, yet membrane selection and operating conditions remain the most critical challenges. This study systematically evaluates the performance of polymeric ultrafiltration (UF) and nanofiltration (NF) membranes for starch hydrolysate syrup treatment. Experiments were conducted in a lab-scale cross-flow filtration system using five UF and three NF flat-sheet polymeric membranes under varying temperatures, transmembrane pressures, and feed concentrations. Separation performance was assessed through colour removal, sugar recovery, permeate flux, and alongside indicators of fouling behaviour. UF membranes with molecular weight cut-offs of 100, 70, and 5 kDa exhibited the most favourable performance at 60 °C and 8 bar, achieving partial colour removal (18–32%) with high permeate fluxes (84–130 kg·m−2·h−1) and limited sugar losses (0.7–19.9%). NF membranes showed significantly higher colour rejection (32–100%) but were associated with substantial sugar losses (up to 96%), limiting their applicability for selective decolourisation; however, their high sugar retention capacity suggests potential for product concentration and the removal of low-molecular-weight impurities. Overall, UF represents a suitable approach for partial colour removal in starch hydrolysates, while NF may be better suited for product concentration and the removal of low-molecular-weight impurities, as well as auxiliary applications such as water recovery. These findings provide a systematic basis for membrane selection and process optimisation in industrial starch hydrolysate purification.
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(This article belongs to the Special Issue Application of Membrane Technologies in Food Processing)
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Open AccessArticle
Fabrication of Ordered Mesoporous Silica/Polyethersulfone Mixed-Matrix Membranes for Improved Removal of Middle-Molecule Toxins Within Hemodialysis
by
Rongrong Ji, Peiyan Shi, Ting Dong, Wenjie Hou and Kangjian Tang
Membranes 2026, 16(7), 250; https://doi.org/10.3390/membranes16070250 - 21 Jul 2026
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As the core component of an artificial kidney, a hemodialysis membrane can remove metabolic wastes and excess fluid from the blood while retaining essential proteins. Despite their essential role in blood purification, current hemodialysis membranes still show limited efficiency in clearing middle-molecule uremic
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As the core component of an artificial kidney, a hemodialysis membrane can remove metabolic wastes and excess fluid from the blood while retaining essential proteins. Despite their essential role in blood purification, current hemodialysis membranes still show limited efficiency in clearing middle-molecule uremic toxins, especially β2-microglobulin. Ordered mesoporous silica (SBA-15) was used as an inorganic pore-regulating additive to construct ordered mesoporous silica/polyethersulfone (PES) mixed-matrix membranes for separation applications. The incorporation of SBA-15 may help form additional effective transport pathways in the PES membrane by regulating pore formation, increasing membrane hydrophilicity, and improving apparent pore connectivity, thereby reducing the apparent transport resistance of middle-molecule solutes. As a result, the composite membranes achieved improved dialysis performance while maintaining high BSA retention. The SBA-15 loading was systematically optimized. Relative to the pristine PES membrane, the 7 wt.% SBA-15 membrane reduced the water contact angle from 65.1° to 49.0° and increased lysozyme reduction from 40.9% to 55.2%, with pure water permeability reaching 261.5 L m−2 h−1 bar−1 and bovine serum albumin (BSA) retention remaining above 90%. These results suggest that SBA-15 may regulate the pore structure of PES membranes and improve apparent pore connectivity, thereby facilitating middle-molecule solute transport while maintaining high BSA retention.
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Open AccessArticle
Identification and Characterization of a Phenyl(trifluoro-methyl)-pyrimidine Positive Allosteric Modulator of the Secretin Receptor
by
Kaleeckal G. Harikumar, Daniela G. Dengler, Leire Borrega Roman, Robert Ardecky, Eduard A. Sergienko and Laurence J. Miller
Membranes 2026, 16(7), 249; https://doi.org/10.3390/membranes16070249 - 21 Jul 2026
Abstract
G protein-coupled receptors (GPCRs) are among the most common drug targets, with numerous agonists and antagonists approved for clinical use. More recently, it has been appreciated that drugs can also modulate the action of natural agonists of these receptors, thus providing unique clinical
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G protein-coupled receptors (GPCRs) are among the most common drug targets, with numerous agonists and antagonists approved for clinical use. More recently, it has been appreciated that drugs can also modulate the action of natural agonists of these receptors, thus providing unique clinical advantages. Here, we describe the identification and characterization of a small molecule positive allosteric modulator (PAM) of secretin action at the class B G protein-coupled secretin receptor. This phenyl(trifluoromethyl)-pyrimidine can occupy the secretin receptor without stimulating its internalization, yet priming it to enhance both the potency and efficacy of the action of natural secretin. This is also shown to exhibit its effects on cells expressing low numbers of these receptors, without enhancing the effects of other structurally related hormones acting at other class B GPCRs. The mechanism responsible for this PAM effect is the slowing of the off-rate of receptor-bound secretin. This compound can serve as a lead to the development of other drugs that enhance the action of natural endogenous secretin and can be utilized to explore the potential therapeutic utility of such compounds.
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(This article belongs to the Section Biological Membranes)
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Open AccessArticle
Selective Separation of Inorganic and Organic Carbonates in Aqueous Solutions by Reverse Osmosis (RO) and Nanofiltration (NF) Membranes
by
Rahma Al Busaidi, Budoor Al Umairi, Zulfiqar Ahmad Rehan and Mohammed Al-Abri
Membranes 2026, 16(7), 248; https://doi.org/10.3390/membranes16070248 - 20 Jul 2026
Abstract
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This study presents a systematic comparison of commercial reverse osmosis (RO) and nanofiltration (NF) membranes for the separation of inorganic and organic carbonates from aqueous solutions, providing insight into the roles of membrane pore structure and surface charge in governing separation mechanisms. Membrane
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This study presents a systematic comparison of commercial reverse osmosis (RO) and nanofiltration (NF) membranes for the separation of inorganic and organic carbonates from aqueous solutions, providing insight into the roles of membrane pore structure and surface charge in governing separation mechanisms. Membrane molecular weight cut-off (MWCO), zeta potential, and thermal stability were characterized and correlated with separation performance. The RO membrane exhibited a lower MWCO and a more negative surface charge than the NF membrane, resulting in superior rejection of both inorganic and organic carbonates. For inorganic carbonates, rejection increased with pH owing to enhanced carbonate ionization and stronger electrostatic repulsion, reaching 91–98% for the RO membrane compared with 60–95% for the NF membrane. In contrast, the rejection of neutral organic carbonates was governed primarily by steric exclusion, with the RO membrane achieving approximately 80% rejection, whereas the NF membrane exhibited negligible removal. These findings demonstrate the combined influence of membrane pore size and surface charge on carbonate separation and provide practical guidance for selecting commercial membranes for efficient carbonate removal in water treatment applications.
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Open AccessArticle
Experimental Design–Guided Optimization of Pervaporative Dehydration of an Esterification Mixture
by
Fatimatou Toure Lo, Magalie Claeys-Bruno, Philippe Moulin and Emilie Carretier
Membranes 2026, 16(7), 247; https://doi.org/10.3390/membranes16070247 - 18 Jul 2026
Abstract
This study investigates the pervaporation dehydration of a quaternary esterification mixture containing water, 2-ethylhexyl acrylate, 2-ethylhexanol, and propionic acid using a pilot-scale HybSi membrane (BTESE on Al2O3). A design of experiments was implemented to evaluate the influence of mixture
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This study investigates the pervaporation dehydration of a quaternary esterification mixture containing water, 2-ethylhexyl acrylate, 2-ethylhexanol, and propionic acid using a pilot-scale HybSi membrane (BTESE on Al2O3). A design of experiments was implemented to evaluate the influence of mixture composition on water content in the retentate, permeation flux, and water removal efficiency. Descriptive analysis revealed that the initial water content is the dominant factor governing both permeation flux and dehydration performance, whereas acid, alcohol, and ester have secondary but interactive effects. Reduced cubic polynomial models including linear, binary, and ternary interactions were developed, showing good agreement with experimental data. Ternary diagrams highlighted composition regions where molecular interactions significantly affect separation performance. Multi-response optimization based on desirability functions identified optimal operating conditions at high initial water content (1.146 wt.%), yielding a permeation flux of 0.144 kg·m−2·h−1, a final water content close to the industrial target (0.2 wt.%), and a water removal efficiency of 86%. Experimental validation confirmed the reliability of the predictive model. The results provide insights into composition–performance relationships and demonstrate the suitability of BTESE membranes for low-water-content esterification systems.
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(This article belongs to the Section Membrane Applications for Other Areas)
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Open AccessArticle
Numerical Solution of the Problem of Relaxation Filtration of a Suspension Through a Radial Filter at a Constant Flow Velocity
by
Volodymyr Brazhenko, Bakhtiyor Kh. Khuzhayorov, Usmonali Saydullaev, Jamol Makhmudov and Iroda Beknazarova
Membranes 2026, 16(7), 246; https://doi.org/10.3390/membranes16070246 - 17 Jul 2026
Abstract
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This paper investigates the relaxation filtration of a suspension through a radial filter surface under conditions of constant flow velocity. A mathematical model for relaxation cake growth is formulated based on the liquid-phase continuity equation, Darcy’s relaxation law, and constitutive relations for both
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This paper investigates the relaxation filtration of a suspension through a radial filter surface under conditions of constant flow velocity. A mathematical model for relaxation cake growth is formulated based on the liquid-phase continuity equation, Darcy’s relaxation law, and constitutive relations for both compressive and liquid pressures. The resulting governing equation is a nonlinear partial differential equation for the compressive pressure, complemented by a Stefan condition that characterizes the motion of the cake–slurry interface. The moving-boundary problem is solved numerically using a finite difference method employing a coordinate-based front-tracking technique combined with iterative procedures. The numerical results demonstrate the influence of relaxation effects on cake formation. Increasing the relaxation time slows the compaction process, thereby maintaining higher porosity and promoting accelerated growth of the cake layer thickness.
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