14 November 2026
Pulsed electromagnetic field (PEMF) therapy has attracted interest in knee osteoarthritis (OA) because it can influence cellular signaling and tissue responses through a noninvasive physical stimulus. However, PEMF is not a uniform intervention, and...
14 November 2026
Background/Objectives: Ambulatory blood pressure monitoring (ABPM) is valuable for assessing circadian blood pressure patterns in hypertensive patients with type 2 diabetes mellitus (T2DM). This study aimed to evaluate the association between circadi...
14 November 2026
Background/Objectives: Interest in herbal medicine continues to grow because plant-based products are often viewed as safer complements or alternatives to conventional therapy. This study investigated the phenolic profile of Mentha × piperita L...
14 November 2026
Background/Objectives: Endothelins (ETs) are vascular peptides and elevated ET-1 is linked to cardiovascular, pregnancy complications. Environmental exposures, namely, air pollution, have been shown to enhance plasma ET-1 with related adverse pregnan...
14 November 2026
Background/Objectives: Hyperemesis gravidarum (HEG) has been associated with systemic inflammation, but blood-count-derived markers have shown only modest diagnostic value. We evaluated the inflammatory prognostic index (IPI), which combines the C-re...
13 November 2026
Background: Accurate and non-invasive prediction of response to neoadjuvant chemoradiotherapy (NCRT) and long-term outcomes in patients with locally advanced rectal cancer (LARC) remains challenging. This multicenter study developed and validated mac...
13 November 2026
Background/Objectives: We compared five admission complete blood count (CBC)-derived indices in relation to anatomical injury severity among adults with multiple blunt injuries undergoing orthopedic surgery. Methods: This retrospective study included...
Background: Glioblastoma (GBM) shows marked metabolic plasticity and resistance to conventional therapies, which has motivated the search for adjunctive metabolic strategies. Medium-chain fatty acids (MCFAs) are candidate metabolic modulators, but th...
Background/Objectives: Chronic ocular hypertension (COH) models are essential for glaucoma research. In this study, we established a mouse COH model by in situ photocrosslinking of methacrylated hyaluronic acid (MAHA). Methods: A 2% (w/v) MAHA precur...
Secretory immunoglobulin A (SIgA) represents the most abundant antibody isotype at mucosal surfaces and plays a central role in maintaining intestinal immune homeostasis. In addition to its classical function in immune exclusion of pathogens, SIgA ac...
Background/Objectives: Succinic acid, a tricarboxylic acid cycle intermediate, is antiproliferative in endometrial cancer cells, where it previously increased RIPK1. We examined necroptosis pathway transcripts in endometrial carcinoma HEC-1B cells an...
Background: Conventional semen analysis remains the cornerstone of male infertility diagnostics; however, its predictive value for fertilization potential and assisted reproductive technology (ART) outcomes remains limited. Molecular alterations in s...
Background/Objectives: Cardiovascular involvement may remain clinically silent in inflammatory rheumatic diseases (IRDs), and few studies have compared cardiac structure and myocardial deformation across major IRDs using one echocardiographic protoco...
Lipid-based nanocarriers, especially vesicular systems such as liposomes, have gained an important place in the development of nanomedicines due to their biocompatibility and ability to simultaneously encapsulate hydrophilic and lipophilic cargoes. H...
Kaposi sarcoma is a vascular tumor that remains a significant global public health challenge, with approximately 70% of cases occurring in sub-Saharan Africa (SSA) where Human Immunodeficiency Virus (HIV) and Human Herpesvirus 8 (HHV-8) are highly pr...
Background/Objectives: Epilepsy affects more than 50 million people worldwide, and approximately one-third of patients exhibit drug resistance to conventional treatments. In this context, terpene compounds have emerged as promising alternatives due t...
Pseudohypertriglyceridemia (pseudo-HTG) is a rare laboratory phenomenon in which serum triglyceride levels are falsely elevated due to analytical interference from endogenous glycerol, most often caused by glycerol kinase deficiency (GKD), an X-linke...
Skin inflammation has been proposed as a systemic factor relevant to female reproductive health, but the strength of evidence differs markedly across dermatologic conditions and reproductive endpoints. In a UK population-based cohort, moderate-to-sev...
Background/Objectives: Symptomatic carotid plaques exhibit inflammatory and structural-cell-associated expression signatures. We compared bulk plaque transcriptomes by clinical presentation and explored the transcriptional context of nuclear receptor...
Background: Platinum chemotherapy causes irreversible sensorineural hearing loss in a large fraction of treated patients. Inherited mitochondrial DNA (mtDNA) variation—most famously the 12S rRNA m.1555A>G mutation—is an established cau...
Inflammatory bowel disease (IBD) is a chronic relapsing disorder with increasing global prevalence and persistent therapeutic challenges. Marine sulfated polysaccharides (MSPs) have attracted growing interest because of their structural diversity and...
Background/Objectives: β-D-Glucan accounts for much of the immunomodulatory and anticancer activity of Ophiocordyceps sinensis, yet there is still no green, efficient way to recover it from cultured mycelium, and subcritical water extraction (SW...
Background/Objectives: Biologic therapies have expanded treatment options for severe chronic rhinosinusitis with nasal polyps (CRSwNP), but biomarkers that can guide treatment selection or monitoring remain uncertain. This scoping review aimed to map...
Background/Objectives: C-reactive protein (CRP) and D-dimer are routinely measured in sepsis, but it is uncertain whether their repeated values covary within the same hospital episode independently of differences between episodes. We therefore evalua...
Background: Li–Fraumeni syndrome (LFS) is a clinically and genetically heterogeneous autosomal dominant hereditary cancer syndrome characterized by early-onset tumors, multiple primary cancers, and a strong family history of cancer. Unlike most...
Introduction: The combination of enfortumab vedotin and pembrolizumab (EVP) has become standard first-line therapy in metastatic urothelial carcinoma (mUC). Yet little is known regarding the impact of prior exposure to checkpoint inhibition (CPI) in...
Background: The interleukin-6 receptor (IL6R) mediates classical and trans-signaling through the IL-6 pathway. Although IL-6/JAK/STAT signaling has been extensively investigated in breast cancer (BRCA) and uterine corpus endometrial carcinoma (UCEC),...
Background/Objectives: The liver is responsible for crucial functions such as digestion, metabolism, detoxification, and immune regulation. These roles are severely compromised in chronic liver diseases, which affect 1.7 billion people globally and c...
Background/Objectives: Circulating microRNAs (miRNAs) are potential minimally invasive biomarkers of metabolic dysfunction-associated steatotic liver disease (MASLD). miR-122 is associated with hepatocyte homeostasis and injury, whereas miR-29a is in...
Background. Coronary artery disease frequently develops as a consequence of type 2 diabetes mellitus, which leads to an exacerbation of both diseases. Persistently elevated glucose levels promote glycation of proteins and lipids, induce chronic infla...
Background/Objectives: Congenital melanocytic nevi in aesthetically important areas are difficult to treat because excision may require extensive surgery and cause scarring. Photodynamic therapy (PDT) may be less traumatic, but data on its use for th...
Background/Objectives: Acute pancreatitis (AP) is a severe inflammatory disorder driven by complex immune responses and oxidative stress. While macrophages are central to AP pathogenesis, the subsets associated with oxidative stress remain poorly def...
Background and Objectives: Diabetes mellitus (Type 2 diabetes) is a significant and rapidly growing global healthcare challenge and a leading cause of severe complications, including cardiovascular disease (CVD), chronic kidney disease and other cond...
Background: Carotid artery stenosis (CAS) is currently one of the leading causes of ischemic stroke. In these patients, the primary factor leading to stroke is the presence of vulnerable atherothrombotic plaques rather than the degree of stenosis its...
Neutrophil activation biomarkers have attracted increasing interest as potential indicators of host-response activation, organ dysfunction, and prognosis in sepsis. This narrative review critically examines the biological mechanisms, diagnostic and p...
Objective: We aimed to investigate the regulatory effects of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] pretreatment on the in vitro osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs), to evaluate the ectopic osteogenic...
Background: Antibody–drug conjugates (ADCs) have emerged as an important class of targeted anticancer therapeutics; however, their efficacy can be limited by intrinsic or acquired resistance to their cytotoxic payloads. Pharmacological potentia...
Implantation failure remains a major challenge in assisted reproductive technology (ART) and is increasingly recognized as a heterogeneous phenomenon arising from the complex interplay between embryo competence, endometrial receptivity, and maternal...
Cells are the basic structural and functional units of tissues, and they all experience changes with aging—they get larger, with less ability to divide and multiply, and many of them lose their ability to function or start to function abnormall...
Background/Objectives: Retinal vessel features are often added to fundus classifiers without isolating their effect. We examined whether global vessel descriptors improve multi-disease fundus classification under leakage-controlled external testing....
Background/Objectives: Hyperkalaemia affects 2–4% of the general population. Real-world data in Greece are currently limited. The SHIELD study assessed treatment patterns and disease management of patients with hyperkalaemia in Greece. Methods:...
Background: Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus characterized by chronic non-healing wounds and a high risk of amputation, and early molecular diagnosis remains an unmet clinical need. Methods: RNA-sequencing data...
Background/Objectives: The human telomerase reverse transcriptase (hTERT) maintains mitochondrial DNA, modulates the release of reactive oxygen species, and contributes to axonal regeneration. Previous work reported that hTERT levels in the tear film...
Background: Endometriosis is an oestrogen-dependent chronic inflammatory disease with chronic pelvic pain as a predominant and disabling symptom that severely compromises patient quality of life. The molecular mechanisms governing endometriosis-assoc...
Background: Microbiota-related metabolites and innate immune signaling molecules transported via plasma-derived extracellular vesicle (EV)-enriched fractions through the gut–brain axis may contribute to neuroinflammation and disease progression...
Background: Glutamatergic and metabolic dysregulation are implicated in Alzheimer’s disease (AD), making circulating metabolites attractive targets. Prior Mendelian randomization (MR) studies mostly tested binary clinical diagnoses—a hete...
Background/Objectives: Cardiovascular–kidney–metabolic (CKM) syndrome is a recently defined systemic disorder linking metabolic dysfunction with cardiovascular and renal disease. Clinical evidence suggests that pro-inflammatory dietary pa...
Background/Objectives: Hemorrhagic shock leads to critical malperfusion of organs including the kidneys. Current hemodynamic approaches focus on macrocirculatory targets such as mean arterial pressure (MAP), which may not reliably reflect organ-level...
Background: Breast cancer is one of the most common malignancies among women worldwide and remains one of the leading causes of cancer-related mortality. Accurate prediction of breast cancer recurrence is clinically important for patient survival, tr...
Objective: To investigate the antitumor effects of maackiain (MAA), a naturally occurring pterocarpan found in Sophora flavescens, and clarify its molecular mechanism in hepatocellular carcinoma (HCC). Methods: Network pharmacology was integrated wit...
