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Livers, Volume 3, Issue 1

March 2023 - 11 articles

Cover Story: Non-alcoholic fatty liver disease (NAFLD) is the most frequently occurring chronic liver disease. NAFLD reflects excess hepatic accumulation of fat in the absence of increased alcohol intake and due to its close association with obesity. In addition to its well-established link with the metabolic syndrome and increased risk for cardiovascular disease, NAFLD has also been associated with certain mental health issues. As such, this review aimed to assess such potential problems faced by patients with NAFLD and to explore the possibility of unmet support needs which could lead to perceived social isolation. Moreover, the importance of a compassionate approach towards such patients is discussed, together with potential coping strategies. Future research directions and the need for a multidisciplinary approach are also highlighted. View this paper
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Articles (11)

  • Review
  • Open Access
10 Citations
12,410 Views
40 Pages
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Unresectable Hepatocellular Carcinoma: A Review of New Advances with Focus on Targeted Therapy and Immunotherapy

  • Bahareh Farasati Far,
  • Dorsa Rabie,
  • Parisa Hemati,
  • Parastoo Fooladpanjeh,
  • Neda Faal Hamedanchi,
  • Nima Broomand Lomer,
  • Arian Karimi Rouzbahani and
  • Mohammad Reza Naimi-Jamal
Livers2023, 3(1), 121-160;https://doi.org/10.3390/livers3010011

13 March 2023

With an expected incidence of more than 1 million cases by 2025, liver cancer remains a problem for world health. With over 90% of cases, hepatocellular carcinoma (HCC) is the most prevalent kind of liver cancer. In this review, we presented the rang...

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  • Article
  • Open Access
5 Citations
3,691 Views
16 Pages
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Tempol Alters Antioxidant Enzyme Function, Modulates Multiple Genes Expression, and Ameliorates Hepatic and Renal Impairment in Carbon Tetrachloride (CCl4)-Intoxicated Rats

  • Ishrat Jahan,
  • Md. Didarul Islam,
  • Sumaia Sarif,
  • Israt Jahan Amena,
  • Asif Ul Haque Shuvo,
  • Noushin Akter,
  • Faizul Islam Chowdhury,
  • Raushanara Akter,
  • Iqbal Ahmed and
  • Ferdous Khan
  • + 2 authors
Livers2023, 3(1), 105-120;https://doi.org/10.3390/livers3010010

8 March 2023

The purpose of this study was to determine the effect of the superoxide dismutase mimic compound “tempol” on liver and renal damage in Long Evans male rats administered with carbon tetrachloride (CCl4). Methods: The antioxidant enzyme act...

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  • Article
  • Open Access
1 Citations
4,981 Views
12 Pages
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Single Center Experience of Oral Vancomycin Therapy in Young Patients with Primary Sclerosing Cholangitis: A Case Series

  • Amala J. Alenchery,
  • Sophia Patel,
  • Lori Mahajan,
  • Jacob A. Kurowski,
  • Sarah Worley,
  • Vera Hupertz,
  • Kaddakal Radhakrishnan and
  • Mohammad Nasser Kabbany
Livers2023, 3(1), 93-104;https://doi.org/10.3390/livers3010009

6 March 2023

There is no single proven therapy that prolongs hepatic transplant-free survival in patients with primary sclerosing cholangitis (PSC). Oral vancomycin (OV) has shown some benefit in small pediatric and adult series. We describe the effect of OV on p...

Full Article
  • Review
  • Open Access
5 Citations
3,057 Views
11 Pages
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Role of Genetic and Epigenetic Modifications in the Progression of Hepatocellular Carcinoma in Chronic HCV Patients

  • Anum Syyam,
  • Hira Raheem Akbar,
  • Zuzana Macek Jilkova and
  • Samia Afzal
Livers2023, 3(1), 82-92;https://doi.org/10.3390/livers3010008

20 February 2023

Globally, hepatocellular carcinoma (HCC) is a significant cause of mortality and morbidity among chronically infected HCV patients. It is established that HCV is a primary risk factor for HCC progression. The treatment of HCV infection has been trans...

Full Article
  • Opinion
  • Open Access
2 Citations
3,682 Views
6 Pages
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Liver Transplantation and dd-cfDNA: A Small Solution for a Big Problem

  • Eleni Avramidou,
  • Stella Vasileiadou,
  • Nikolaos Antoniadis,
  • Georgios Katsanos,
  • Athanasios Kofinas,
  • Konstantina-Eleni Karakasi and
  • Georgios Tsoulfas
Livers2023, 3(1), 76-81;https://doi.org/10.3390/livers3010007

20 February 2023

Dd-cfDNA is a novel biomarker with many diagnostic applications in various areas of medicine. In this review of the literature, we investigate its role in the diagnosis of many complications that occur in liver transplantations. In our review, we ret...

Full Article
  • Review
  • Open Access
8 Citations
14,866 Views
11 Pages
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Bio-Artificial Liver Support System: A Prospective Future Therapy

  • Chyntia Olivia Maurine Jasirwan,
  • Akhmadu Muradi and
  • Radiana Dhewayani Antarianto
Livers2023, 3(1), 65-75;https://doi.org/10.3390/livers3010006

9 February 2023

Whether acute or chronic, liver failure is a state of liver dysfunction that can progress to multiorgan failure. Mortality in liver failure patients is approximately 80–90% and is caused by detoxification failure, which triggers other immediate...

Full Article
  • Case Report
  • Open Access
5,485 Views
9 Pages
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Lights and Shadows of Paracentesis: Is an Ultrasound Guided Approach Enough to Prevent Bleeding Complications?

  • Marta Patturelli,
  • Luca Pignata,
  • Pietro Venetucci and
  • Maria Guarino
Livers2023, 3(1), 54-62;https://doi.org/10.3390/livers3010004

16 January 2023

Paracentesis is a validated procedure for diagnosing and managing ascites. Although paracentesis is a safe procedure with a 1–2% risk of complications such as bleeding, it is necessary to inform the patient about the possible adverse events. We...

Full Article
  • Review
  • Open Access
22 Citations
13,742 Views
21 Pages
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Acetaminophen-Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review

  • Karima Begriche,
  • Clémence Penhoat,
  • Pénélope Bernabeu-Gentey,
  • Julie Massart and
  • Bernard Fromenty
Livers2023, 3(1), 33-53;https://doi.org/10.3390/livers3010003

12 January 2023

The epidemic of obesity, type 2 diabetes and nonalcoholic liver disease (NAFLD) favors drug consumption, which augments the risk of adverse events including liver injury. For more than 30 years, a series of experimental and clinical investigations re...

Full Article
  • Opinion
  • Open Access
8 Citations
5,329 Views
12 Pages
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Metabolic Associated Fatty Liver Disease as a Risk Factor for the Development of Central Nervous System Disorders

  • Sayuri Yoshikawa,
  • Kurumi Taniguchi,
  • Haruka Sawamura,
  • Yuka Ikeda,
  • Tomoko Asai,
  • Ai Tsuji and
  • Satoru Matsuda
Livers2023, 3(1), 21-32;https://doi.org/10.3390/livers3010002

5 January 2023

MAFLD/NAFLD is the most ordinary liver disease categorized by hepatic steatosis with the increase of surplus fat in the liver and metabolic liver dysfunction, which is associated with bigger mortality and a high medical burden. An association between...

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