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Neuroglia, Volume 4, Issue 3

September 2023 - 5 articles

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Articles (5)

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Review

11 Citations

5,930 Views

13 Pages

The Role of Astrocytes and Blood–Brain Barrier Disruption in Alzheimer’s Disease

João Victor R. Cruz,
Carolina Batista,
Luan Pereira Diniz and
Fabio A. Mendes

Neuroglia2023, 4(3), 209-221;https://doi.org/10.3390/neuroglia4030015

20 August 2023

The blood–brain barrier (BBB) is a highly intricate neurovascular structure that plays a crucial role in maintaining neural homeostasis by selectively allowing certain molecules to enter the central nervous system (CNS). However, in the context...

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Review

3 Citations

5,976 Views

18 Pages

Overview of the Molecular Modalities and Signaling Pathways Intersecting with β-Amyloid and Tau Protein in Alzheimer’s Disease

Ahmed M. Elshazly,
Melanie M. Sinanian,
Diaaeldin M. Elimam and
Sherin Zakaria

Neuroglia2023, 4(3), 191-208;https://doi.org/10.3390/neuroglia4030014

30 July 2023

Alzheimer’s disease (AD) is one of the major causes of dementia and its incidence represents approximately 60–70% of all dementia cases worldwide. Many theories have been proposed to describe the pathological events in AD, including deter...

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Editorial

2 Citations

2,214 Views

3 Pages

Unraveling the Critical Mechanisms and Functions of Neuroglia in Spinal Cord Injuries

Chih-Wei Zeng

Neuroglia2023, 4(3), 188-190;https://doi.org/10.3390/neuroglia4030013

24 July 2023

In the dynamic landscape of neuroscience and regenerative medicine, the pivotal role of neuroglia, or glial cells, is increasingly being recognized [...]

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Article

3 Citations

4,113 Views

16 Pages

A Human Microglial Cell Line Expresses γ-Aminobutyric Acid (GABA) Receptors and Responds to GABA and Muscimol by Increasing Production of IL-8

Ashley Wagner,
Zhimin Yan and
Marianna Kulka

Neuroglia2023, 4(3), 172-187;https://doi.org/10.3390/neuroglia4030012

28 June 2023

Gamma-aminobutyric acid (GABA) is an essential neurotransmitter and an important regulator of neuroinflammation and disease. Microglia are important immune cells in the brain that express GABA receptors (GABAR) and respond to both GABA and GABAR agon...

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Article

4 Citations

3,036 Views

14 Pages

Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose

Madhu Babu Pasula,
Sagor C. Roy,
Khaggeswar Bheemanapally,
Paul W. Sylvester and
Karen P. Briski

Neuroglia2023, 4(3), 158-171;https://doi.org/10.3390/neuroglia4030011

21 June 2023

The plasma membrane glucose transporter (GLUT)-2 is unique among GLUT family proteins in that it also functions as a glucose sensor. GLUT2 imposes sex-dimorphic control of hypothalamic astrocyte glucose storage and catabolism by unknown mechanisms. M...

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