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J. Compos. Sci.
Volume 7
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10.3390/jcs7050186
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Article

Engineered GO-Silk Fibroin-Based Hydrogel for the Promotion of Collagen Synthesis in Full-Thickness Skin Defect

by
Valeriia Syromiatnikova
1,†,
Sharda Gupta
2,†,
Margarita Zhuravleva
1,
Galina Masgutova
1,
Elena Zakirova
1,
Alexander Aimaletdinov
1,
Albert Rizvanov
1,
Ilnur Salafutdinov
1,3,
Ekaterina Naumenko
1,* and
Arindam Bit
2,*
1
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia
2
Department of Biomedical Engineering, National Institute of Technology, Raipur 492001, India
3
Department of Medical Biology and Genetics, Kazan State Medical University, 420012 Kazan, Russia
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
J. Compos. Sci. 2023, 7(5), 186; https://doi.org/10.3390/jcs7050186
Submission received: 3 March 2023 / Revised: 24 April 2023 / Accepted: 1 May 2023 / Published: 5 May 2023
(This article belongs to the Section Composites Applications)
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Abstract

In order to improve the regeneration of full-layer skin defects, hydrogels were developed based on the combination of chitosan (Cs), Daba silk fibroin (DSF), and graphene oxide (GO): CS, DSF/Cs and DSF/Cs/GO. The biocompatibility of hydrogels with human dermis fibroblasts in vitro was evaluated using the MTS assay. To assess the regenerative potential of hydrogels, a model of a full-layer skin defect was reconstructed on the back of rats and closed the wound surface with CS, DSF/Cs and DSF/Cs/GO hydrogels. The morphological and morphometric characteristics of regenerate tissues were obtained by staining with hematoxylin-eosin, Heidengain azocarmine, and immunohistochemistry on days 7 and 14 of the experiment. It has been shown that the use of DSF/Cs and DSF/Cs/GO promotes enhanced healing and epithelization of a full-layer skin wound. The addition of GO to the hydrogel increased the synthetic activity of fibroblasts and improved the characteristics of the produced collagen fibers.
Keywords: hydrogel; chitosan; silk fibroin; graphene oxide; skin wounds hydrogel; chitosan; silk fibroin; graphene oxide; skin wounds

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MDPI and ACS Style

Syromiatnikova, V.; Gupta, S.; Zhuravleva, M.; Masgutova, G.; Zakirova, E.; Aimaletdinov, A.; Rizvanov, A.; Salafutdinov, I.; Naumenko, E.; Bit, A. Engineered GO-Silk Fibroin-Based Hydrogel for the Promotion of Collagen Synthesis in Full-Thickness Skin Defect. J. Compos. Sci. 2023, 7, 186. https://doi.org/10.3390/jcs7050186

AMA Style

Syromiatnikova V, Gupta S, Zhuravleva M, Masgutova G, Zakirova E, Aimaletdinov A, Rizvanov A, Salafutdinov I, Naumenko E, Bit A. Engineered GO-Silk Fibroin-Based Hydrogel for the Promotion of Collagen Synthesis in Full-Thickness Skin Defect. Journal of Composites Science. 2023; 7(5):186. https://doi.org/10.3390/jcs7050186

Chicago/Turabian Style

Syromiatnikova, Valeriia, Sharda Gupta, Margarita Zhuravleva, Galina Masgutova, Elena Zakirova, Alexander Aimaletdinov, Albert Rizvanov, Ilnur Salafutdinov, Ekaterina Naumenko, and Arindam Bit. 2023. "Engineered GO-Silk Fibroin-Based Hydrogel for the Promotion of Collagen Synthesis in Full-Thickness Skin Defect" Journal of Composites Science 7, no. 5: 186. https://doi.org/10.3390/jcs7050186

APA Style

Syromiatnikova, V., Gupta, S., Zhuravleva, M., Masgutova, G., Zakirova, E., Aimaletdinov, A., Rizvanov, A., Salafutdinov, I., Naumenko, E., & Bit, A. (2023). Engineered GO-Silk Fibroin-Based Hydrogel for the Promotion of Collagen Synthesis in Full-Thickness Skin Defect. Journal of Composites Science, 7(5), 186. https://doi.org/10.3390/jcs7050186

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