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Proceedings, Volume 79, Issue 1

IECBM 2020 2021 - 15 articles

The 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases

Online | 1–13 December 2020

Volume Editors:
Vladimir Uversky, University of South Florida, USA
Prakash Kulkarni, City of Hope National Medical Center, USA
Marc Maresca, Aix-Marseille University, CNRS, Centrale Marseille, iSm2, France

Cover Story: The 1st International Electronic Conference on Biomolecules: Natural and Bio-Inspired Therapeutics for Human Diseases (IECBM2020) is organized by the MDPI open-access journal Biomolecules. This conference provides leading scientists working in the field with an online platform on which to share their latest research and engage in exciting discussions. The main topics and sessions of the conference are: The natural and bio-inspired drug universe; Derivatives of natural drugs: when chemistry allows optimization of what was created by nature; Pathways for the discovery of new bio-inspired and natural drugs and their derivatives; Repurposing of previously approved natural and bio-inspired drugs.
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Articles (15)

  • Proceeding Paper
  • Open Access
2 Citations
2,583 Views
9 Pages
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In Silico Study of 5,7-Dimethoxycoumarin and p-Coumaric Acid in Carica papaya Leaves as Dengue Virus Type 2 Protease Inhibitors

  • Samith Rathnayake,
  • Ayesh Madushanka,
  • N.D. Asha Dilrukshi Wijegunawardana,
  • Harthika Mylvaganam,
  • Ajith Rathnayake,
  • Eranga Geethanjana Perera,
  • Ishara Jayamanna,
  • Priyantha Chandrasena,
  • Ahinsa Ranaweera and
  • Prasad Jayasooriya
  • + 1 author
Proceedings2021, 79(1), 11;https://doi.org/10.3390/IECBM2020-08820

2 December 2020

Dengue virus is a serious public health issue in tropical and subtropical regions. The global incidence of dengue necessitates the potent antiviral medication for the prevention of proliferation of the virus inside the human body. The DEN2 NS2B/NS3 p...

Full Article
  • Proceeding Paper
  • Open Access
5 Citations
7,923 Views
5 Pages
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Lentinan for Integrative Cancer Treatment: An Umbrella Review

  • Michele Antonelli,
  • Davide Donelli and
  • Fabio Firenzuoli
Proceedings2021, 79(1), 1;https://doi.org/10.3390/IECBM2020-08733

1 December 2020

The aim of this review is to understand whether lentinan can be a useful integrative remedy for cancer patients. PubMed, EMBASE, Web of Science, Cochrane Library and Google Scholar were screened for relevant meta-analyses from inception to 29th Septe...

Full Article
  • Proceeding Paper
  • Open Access
1 Citations
1,744 Views
6 Pages
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Therapeutic Bio-Compounds from Avocado Residual Biomass

  • Minerva C. García-Vargas,
  • María del Mar Contreras and
  • Eulogio Castro
Proceedings2021, 79(1), 4;https://doi.org/10.3390/IECBM2020-08656

1 December 2020

Since ancient times, plants have been used as preservatives, spices, flavorings and as natural remedies to prevent or treat diseases owing to the biological activity correlated with the bioactive compounds they contain. The avocado fruit (Persea amer...

Full Article
  • Proceeding Paper
  • Open Access
2 Citations
1,545 Views
7 Pages
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Antiproliferative and Apoptotic Activity of Polyphenol-Rich Crude Methanol Extract of Gracillaria edulis against Human Rhabdomyosarcoma (Rd) and Breast Adenocarcinoma (Mcf-7) Cell Lines

  • Thilina Lakmini Gunathilaka,
  • Kalpa Samarakoon,
  • Pathmasiri Ranasinghe and
  • Dinithi Champika Peiris
Proceedings2021, 79(1), 6;https://doi.org/10.3390/IECBM2020-08655

1 December 2020

Seaweeds are an important source of bioactive metabolites in the development of drugs and nutraceuticals. This study aimed to analyze the antiproliferative and apoptotic activities of the methanol extract (ME) of G. edulis using human Rhabdomyosarcom...

Full Article
  • Proceeding Paper
  • Open Access
11 Citations
5,035 Views
8 Pages
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In-Vitro Antidiabetic Propensities, Phytochemical Analysis, and Mechanism of Action of Commercial Antidiabetic Polyherbal Formulation “Mehon”

  • Saptadipa Paul and
  • Mala Majumdar
Proceedings2021, 79(1), 7;https://doi.org/10.3390/IECBM2020-08805

1 December 2020

Present investigation assessed the hypoglycemic potential of hydro-alcoholic (HAE) and aqueous (AQE) extracts of Mehon, a commercial antidiabetic polyherbal formulation using various in vitro techniques. HAE and AQE were analyzed for α-amylase and α-...

Full Article
  • Proceeding Paper
  • Open Access
5 Citations
3,318 Views
8 Pages
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Ultra-Short Cyclo-Peptides as Bio-Inspired Therapeutics: Proline-Based 2,5-Diketopiperazines (DKP)

  • Joanna Bojarska and
  • Wojciech M. Wolf
Proceedings2021, 79(1), 10;https://doi.org/10.3390/IECBM2020-08804

1 December 2020

2,5-diketopiperazines (DKP) are the simplest cyclo-peptides in nature, which could play a key role in the origin of life. They are ubiquitous in microorganisms, higher species, and in food and beverages. These dipeptides have been known since the beg...

Full Article
  • Proceeding Paper
  • Open Access
1 Citations
2,851 Views
7 Pages
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The Utilization of Urolithin A—A Natural Polyphenol Metabolite of Ellagitannins as a Modulator of the Gut Microbiota for Its Potential Use in Obesity Therapy

  • Abdulrasheed O. Abdulrahman,
  • Mohammed Yahya Alzubaidi,
  • Muhammad Shahid Nadeem,
  • Jalaluddin Awlia Khan,
  • Irfan A. Rather and
  • Mohammad Imran Khan
Proceedings2021, 79(1), 12;https://doi.org/10.3390/IECBM2020-08806

1 December 2020

Obesity, a global health concern, is associated with the dysbiosis of intestinal microbial composition. This study aims to investigate the potential of urolithin A (Uro-A) in reducing body weight gain through modulation of the gut microbiota. Rats we...

Full Article
  • Proceeding Paper
  • Open Access
2,124 Views
17 Pages
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Assessment of NF-κB-SN50’s Effect on Adipose Tumor Necrosis Factor-Alpha and Angiotensinogen Secretion and Expression

  • Lotfi S. Bin Dahman,
  • Nasser M. Al-Daghri,
  • Assim A. Alfadda,
  • Reem M. Sallam and
  • Philip G. McTernan
Proceedings2021, 79(1), 15;https://doi.org/10.3390/IECBM2020-08579

30 November 2020

Central adiposity is one of the significant determinants of obesity-related hypertension risk, which may arise because of the pathogenic inflammatory nature of the abdominal fat depot. Pro-inflammatory cytokine and adipokine upregulation through nucl...

Full Article
  • Proceeding Paper
  • Open Access
1 Citations
1,840 Views
6 Pages
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Comparison of Untapped Agroindustrial Olive Resources with Olive Leaves

  • María del Mar Contreras,
  • Irene Gómez-Cruz,
  • Inmaculada Romero and
  • Eulogio Castro
Proceedings2021, 79(1), 3;https://doi.org/10.3390/IECBM2020-08585

30 November 2020

Olive leaves are a source of valuable compounds with applications in the phytopharmacy sector, among others. Nevertheless, there are untapped olive resources that can give new clues for the discovery of natural bioactive compounds. Therefore, in this...

Full Article
  • Extended Abstract
  • Open Access
1,434 Views
2 Pages
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Design and Synthesis of a cADPR Mimic as a Novel Tool for Monitoring the Intracellular Ca2+ Concentration

  • Stefano D’Errico,
  • Nicola Borbone,
  • Andrea Patrizia Falanga,
  • Maria Marzano,
  • Monica Terracciano,
  • Francesca Greco,
  • Gennaro Piccialli and
  • Giorgia Oliviero
Proceedings2021, 79(1), 5;https://doi.org/10.3390/IECBM2020-08578

30 November 2020

Cyclic ADP-ribose (cADPR, 1, Figure 1) is a naturally occurring metabolite of NAD+ capable of mobilizing Ca2+ ions from intracellular stores. [...]

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