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Allergies, Volume 3, Issue 2

June 2023 - 3 articles

Cover Story: Glucocorticosteroid therapy remains the standard treatment for asthma, but it has several drawbacks and side effects. Monoclonal antibodies have been explored as an alternative option for severe allergy management, but their potential role in immune-complex formation and autoimmunity is still controversial. mRNA medicine, which has been successfully used in vaccine development, offers a novel approach to deliver antibody therapy for allergy. We propose that mRNA antibody therapy can induce a diverse and specific antibody response in the host that can prevent the sensitization of mast cells, eosinophils, and basophils; clear local IgE through a reticuloendothelial mechanism; and reduce the histamine production of allergy-specific cells. View this paper

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Review

5 Citations

8,439 Views

19 Pages

Genetic and Epigenetic Factors in Risk and Susceptibility for Childhood Asthma

Dimitrina Miteva,
Snezhina Lazova and
Tsvetelina Velikova

Allergies2023, 3(2), 115-133;https://doi.org/10.3390/allergies3020009

14 June 2023

Asthma is a common respiratory disease that affects people of all ages, characterized by considerable heterogeneity in age, clinical presentation, genetics, epigenetics, environmental factors, treatment response, and prognostic outcomes. Asthma affec...

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Article

3 Citations

3,438 Views

10 Pages

Is Switching of Adrenaline Auto Injector Devices a Concern for Anaphylaxis Management? A CROSS-Sectional Study

Caoimhe Cronin,
Ciobha O’Kelly,
Hannah Keohane,
Laura Flores Villarta,
Ciara Tobin,
Roberto Velasco and
Juan Trujillo Wurttele

Allergies2023, 3(2), 105-114;https://doi.org/10.3390/allergies3020008

12 May 2023

Adrenaline auto injectors (AAI) are the mainstay of treatment in anaphylaxis. However, many caregivers of children with food allergies are unable to administer an AAI when assessed. One proposed factor for this finding is the lack of training and fam...

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Review

6 Citations

10,856 Views

15 Pages

Targeting IgE and Th2-Cytokines in Allergy: Brief Updates on Monoclonal Antibodies and Antibody Gene Therapy

Henry C. Ezechukwu,
Oyelola A. Adegboye,
Wahab O. Okunowo and
Theophilus I. Emeto

Allergies2023, 3(2), 90-104;https://doi.org/10.3390/allergies3020007

3 April 2023

The search for an effective treatment of allergic conditions is an ongoing global health challenge due to the high prevalence of allergies. Epinephrine and glucocorticosteroids remain the oldest and most widely used treatment regimen for allergy, and...

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Allergies - ISSN 2313-5786

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