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Journal of Imaging, Volume 4, Issue 12

December 2018 - 14 articles

Cover Story: The aim of this study is to investigate a multimodal imaging system for monitoring retinal neovascularization using photoacoustic microscopy (PAM), optical coherence tomography (OCT), fluorescein angiography (FA), and color fundus photography. Retinal neovascularization was generated using intravitreal injection of the vascular endothelial growth factor (VEGF). PAM and OCT demonstrated changes in the retinal morphology and the spatial extent of retinal neovascularization. The multimodal-imaging platform performs imaging with a high lateral spatial resolution of 4.1 µm for PAM and 3.8 µm for OCT, with a high depth of penetration at a safe energy level. This allows for the visualization of retinal neovascularization and microvasculature morphologic changes after VEGF injection. Acquired PAM and OCT imaging provide 3D volumetric images of the vascular network that improve the characterization of the microvasculature in a safe manner in rabbit eyes.
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Articles (14)

  • Review
  • Open Access
32 Citations
10,360 Views
24 Pages

12 December 2018

Photoacoustic ophthalmoscopy (PAOM) is a novel, hybrid, non-ionizing, and non-invasive imaging technology that has been used to assess the retina. PAOM can provide both anatomic and functional retinal characterizations with high resolution, high sens...

  • Article
  • Open Access
27 Citations
8,690 Views
18 Pages

In Vivo 3D Imaging of Retinal Neovascularization Using Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Imaging

  • Van Phuc Nguyen,
  • Yanxiu Li,
  • Michael Aaberg,
  • Wei Zhang,
  • Xueding Wang and
  • Yannis M. Paulus

12 December 2018

The pathological process of neovascularization of the retina plays a critical role in causing vision loss in several diseases, including diabetes, retinal vein occlusion, and sickle cell disease. Retinal neovascularization can lead to vitreous hemorr...

  • Article
  • Open Access
11 Citations
6,371 Views
19 Pages

11 December 2018

Quantitative photoacoustic tomography is a novel imaging method which aims to reconstruct optical parameters of an imaged target based on initial pressure distribution, which can be obtained from ultrasound measurements. In this paper, a method for r...

  • Article
  • Open Access
31 Citations
7,756 Views
15 Pages

Confidence Estimation for Machine Learning-Based Quantitative Photoacoustics

  • Janek Gröhl,
  • Thomas Kirchner,
  • Tim Adler and
  • Lena Maier-Hein

10 December 2018

In medical applications, the accuracy and robustness of imaging methods are of crucial importance to ensure optimal patient care. While photoacoustic imaging (PAI) is an emerging modality with promising clinical applicability, state-of-the-art approa...

  • Article
  • Open Access
12 Citations
6,420 Views
13 Pages

8 December 2018

The photoacoustic (PA) signal amplitude measured in gold nanosphere suspensions has been shown to increase nonlinearly with the incident excitation fluence. In this work, this effect is exploited to recover the spatial distribution of gold nanopartic...

  • Article
  • Open Access
35 Citations
7,499 Views
11 Pages

Investigation of the Performance of Hyperspectral Imaging by Principal Component Analysis in the Prediction of Healing of Diabetic Foot Ulcers

  • Qian Yang,
  • Shen Sun,
  • William J. Jeffcoate,
  • Daniel J. Clark,
  • Alison Musgove,
  • Fran L. Game and
  • Stephen P. Morgan

7 December 2018

Diabetic foot ulcers are a major complication of diabetes and present a considerable burden for both patients and health care providers. As healing often takes many months, a method of determining which ulcers would be most likely to heal would be of...

  • Article
  • Open Access
5 Citations
5,312 Views
11 Pages

Receive Beam-Steering and Clutter Reduction for Imaging the Speed-of-Sound Inside the Carotid Artery

  • Maju Kuriakose,
  • Jan-Willem Muller,
  • Patrick Stähli,
  • Martin Frenz and
  • Michael Jaeger

7 December 2018

Handheld imaging of the tissue’s speed-of-sound (SoS) is a promising multimodal addition to diagnostic ultrasonography for the examination of tissue composition. Computed ultrasound tomography in echo mode (CUTE) probes the spatial distribution...

  • Article
  • Open Access
20 Citations
7,645 Views
13 Pages

Spatial Referencing of Hyperspectral Images for Tracing of Plant Disease Symptoms

  • Jan Behmann,
  • David Bohnenkamp,
  • Stefan Paulus and
  • Anne-Katrin Mahlein

4 December 2018

The characterization of plant disease symptoms by hyperspectral imaging is often limited by the missing ability to investigate early, still invisible states. Automatically tracing the symptom position on the leaf back in time could be a promising app...

  • Article
  • Open Access
16 Citations
6,288 Views
15 Pages

2 December 2018

Hyperspectral imaging (HSI) technology has been used for various remote sensing applications due to its excellent capability of monitoring regions-of-interest over a period of time. However, the large data volume of four-dimensional multitemporal hyp...

  • Article
  • Open Access
11 Citations
7,758 Views
12 Pages

MRI Robot for Prostate Focal Laser Ablation: An Ex Vivo Study in Human Prostate

  • Reza Seifabadi,
  • Ming Li,
  • Sheng Xu,
  • Yue Chen,
  • Alex Squires,
  • Ayele H. Negussie,
  • Ivane Bakhutashvili,
  • Peter Choyke,
  • Ismail B. Turkbey and
  • Zion Tsz Ho Tse
  • + 1 author

29 November 2018

Purpose: A novel grid-template-mimicking MR-compatible robot was developed for in-gantry MRI-guided focal laser ablation of prostate cancer. Method: A substantially compact robot was designed and prototyped to meet in-gantry lithotomy ergonomics and...

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J. Imaging - ISSN 2313-433X