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J. Imaging 2018, 4(12), 146; https://doi.org/10.3390/jimaging4120146

Exploiting Nonlinear Photoacoustic Signal Generation in Gold Nanospheres for Selective Detection in Serial 3D PA Tomography

1
Institut für Optik und Atomare Physik, Technische Universität Berlin, Straße des 17. Juni 135, 10623 Berlin, Germany
2
Chair for Analytical Chemistry and Institute of Hydrochemistry, Technische Universität München, Marchioninistr. 17, 81377 Munich, Germany
3
Institut für Physik, Martin-Luther-Universität Halle-Wittenberg, Von-Danckelmann-Platz 3, 06120 Halle (Saale), Germany
The authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 4 December 2018 / Accepted: 5 December 2018 / Published: 8 December 2018
(This article belongs to the Special Issue Biomedical Photoacoustic Imaging: Technologies and Methods)
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Abstract

The photoacoustic (PA) signal amplitude measured in gold nanosphere suspensions has been shown to increase nonlinearly with the incident excitation fluence. In this work, this effect is exploited to recover the spatial distribution of gold nanoparticles in tomographic 3D photoacoustic (PA) images against the background contrast provided by absorbers that exhibit a linear relationship between the PA signal amplitude and the fluence. Serial tomographic PA images of a tissue phantom containing gold nanospheres and a tissue-mimicking absorber were acquired. By assessing the linearity of the PA intensity voxel by voxel, the spatial distribution of the gold nanosphere suspension was recovered. The method is shown to enable the robust detection of gold nanoparticles. View Full-Text
Keywords: photoacoustic tomography; gold nanospheres; plasmonic nanoparticles; image analysis photoacoustic tomography; gold nanospheres; plasmonic nanoparticles; image analysis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Schrof, S.; Pang, G.A.; Buchmann, J.; Laufer, J. Exploiting Nonlinear Photoacoustic Signal Generation in Gold Nanospheres for Selective Detection in Serial 3D PA Tomography. J. Imaging 2018, 4, 146.

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