Non-Coding RNA, Volume 9, Issue 6
2023 December - 13 articles
Cover Story: The expression of the TGFb family member NODAL has been correlated with the plasticity and invasiveness of tumour cells, but its implication in melanoma is controversial. A targeted deletion of NODAL exon2 in melanoma cells is now shown to impair their ability to form tumours and to colonize distant tissues. However, this phenotype does not result from the absence of NODAL, but from the disabled expression of a natural antisense transcript of NODAL, now called LADON. LADON transcripts are packaged in secreted exosomes and, through their differential impact on the expression of oncogenes and tumour suppressors, they promote the mesenchymal to amoeboid transition that is key to tumour progression in melanoma. These findings raise the question of LADON’s implication in other types of cancer. View this paper
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Non-Coding RNA - ISSN 2311-553X