Non-Coding RNA, Volume 12, Issue 3
2026 June - 7 articles
Cover Story: Metabolic dysfunction-associated steatotic liver disease (MASLD) is characterized by dysregulated hepatic triglyceride and cholesterol handling. In this study, we investigate the liver-enriched long noncoding RNA Hnf1aos1, the murine ortholog of human HNF1A-AS1, using AAV8-mediated hepatic knockdown in chow- and high-fat-diet (HFD)-fed mice. Under chow conditions, partial Hnf1aos1 knockdown causes selective hepatic cholesterol accumulation, with reduced Vldlr and a trend toward lower Cyp7a1, while hepatic triglycerides and fatty acid uptake genes remain unchanged. Under HFD, knockdown mice develop severe macrovesicular steatosis with increased hepatic triglycerides, elevated Cd36, Pparg, Lpl, and Fasn, and reduced Apob versus HFD controls. These findings support a role for Hnf1aos1 in the diet-dependent control of hepatic lipid composition and metabolic feedback in vivo. View this paper
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Non-Coding RNA - ISSN 2311-553X