Non-coding RNAs in Stem Cell Differentiation and Disease

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: 30 August 2025 | Viewed by 653

Special Issue Editor


E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania
Interests: non-coding RNAs; transcriptomics; chromatin conformation; extracellular vesicles; exosomes; human adipose-derived stem cells; stem cell differentiation; neurogenesis; adipogenesis; osteogenesis; tissue engineering; biocompatibility; biomaterials; magnetic nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-coding RNAs are molecules that can regulate cell fate both during development and in disease by controlling transcriptional or post-transcriptional mechanisms. Recently, ncRNAs have increasingly been discovered to be crucial multipurpose regulators of all biological processes; therefore, they have gained potential functions as biomarkers or as therapeutic targets. Importantly, the alteration in ncRNA expression has been correlated with different diseases, such as Alzheimer’s, metabolic syndrome/diabetes, or cancer. In stem cell differentiation, these molecules can control cell fate, regulating the commitment of stem cells to a certain lineage. Originating from “the dark matter” of the genome, ncRNAs have been identified in all cell types and in intercellular communication mediated by extracellular vesicles, making them viable candidates for diagnostic, prognostic, and therapeutic targets.

This Special Issue aims to establish the emerging role of ncRNAs both in stem cell differentiation and pathological conditions and to identify the regulatory functions of these molecules. This Special Issue welcomes submissions in the form of original articles, reviews, and short communications. This Special Issue will give readers insights into the latest discoveries and advances regarding ncRNA function in stem cell differentiation, as well as in disease progression and/or prevention.

We look forward to receiving your contributions.

Dr. Sorina Dinescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ncRNAs
  • miRNAs
  • lncRNAs
  • exosomes
  • intercellular communication
  • tumour microenvironment
  • stem cell differentiation
  • biomarker

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

26 pages, 1665 KiB  
Review
Role of Non-Coding RNAs in White and Brown Adipose Tissue Differentiation and Development
by Lea Sleiman and Sorina Dinescu
Non-Coding RNA 2025, 11(3), 30; https://doi.org/10.3390/ncrna11030030 - 29 Apr 2025
Viewed by 176
Abstract
Adipocyte differentiation is a complex process in which pluripotent mesenchymal stem cells (MSCs) differentiate and develop into mature fat cells, also known as adipocytes. This process is controlled by various transcription factors, hormones, and signaling molecules that regulate the development of these cells. [...] Read more.
Adipocyte differentiation is a complex process in which pluripotent mesenchymal stem cells (MSCs) differentiate and develop into mature fat cells, also known as adipocytes. This process is controlled by various transcription factors, hormones, and signaling molecules that regulate the development of these cells. Recently, an increasing number of non-coding RNAs (ncRNAs), especially microRNAs (miRNAs), have been established to be involved in the regulation of many biological processes, including adipocyte differentiation, development, metabolism, and energy homeostasis of white and brown adipose tissue. Several in vitro and in vivo studies reported the significant role of ncRNAs in either promoting or inhibiting adipocyte differentiation into white or brown fat cells by targeting specific transcription factors and regulating the expression of key adipogenic genes. Identifying the function of ncRNAs and their subsequent targets contributes to our understanding of how these molecules can be used as potential biomarkers and tools for therapies against obesity, diabetes, and other diseases related to obesity. This could also contribute to advancements in tissue-engineering based treatments. In this review, we intended to present an up-to-date comprehensive literature overview of the role of ncRNAs, including miRNAs, long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), focusing particularly on miRNAs, in regulating the differentiation and development of cells into white and brown adipose tissue. In addition, we further discuss the potential use of these molecules as biomarkers for the development of novel therapeutic strategies for future personalized treatment options for patients. Full article
(This article belongs to the Special Issue Non-coding RNAs in Stem Cell Differentiation and Disease)
Show Figures

Figure 1

Back to TopTop