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Journal of Fungi, Volume 8, Issue 12
December 2022 - 82 articles
Cover Story: The ubiquitin–proteasome system (UPS) mediated rapid protein turnover influences various cellular functions in eukaryotic cells, including fungi. As a subunit of the SCF (Skp1-Cullin-F-box protein) E3 ligase, F-box protein is a key component of UPS that determines the substrate specificity. In this study, we identified and characterized all 20 F-box proteins in Cryptococcus neoformans, the leading cause of fungal meningoencephalitis. We highlighted the important cellular functions of three F-box proteins in detail, including their roles in fungal mating, stress response, antifungal resistance, and cell size regulation, as well as fungal virulence. Our study leads to a better understanding of the function of fungal SCF E3 ligase-mediated UPS in fungal development and pathogenesis. View this paper
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J. Fungi - ISSN 2309-608X