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Congenital Heart Disease: Imaging Diagnosis, Treatment, and Future Challenges
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Congenital Heart Disease: Imaging Diagnosis, Treatment, and Future Challenges

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Pediatric Cardiology and Congenital Heart Disease".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 821

Special Issue Editor

Prof. Dr. Jacek Kolcz

E-Mail Website
Guest Editor
Department of Pediatric Cardiac Surgery, Collegium Medicum, Jagiellonian University, 31-007 Krakow, Poland
Interests: neonatal cardiac surgery; hypoplastic left heart syndrome; single ventricle defects; 3D printing and virtual reality applications; stem cells and regeneration

Special Issue Information

Dear Colleagues

Ove the last several decades, congenital heart disease (CHD) management and outcomes have significantly improved, driven by advances in imaging, enhanced diagnostic accuracy, and innovative therapeutic interventions. This Special Issue, “Congenital Heart Disease: Imaging Diagnosis, Treatment, and Future Challenges”, will explore contemporary developments in CHD, examining emerging technologies and collaborative strategies for better patient outcomes.

We invite the submission of original research and reviews on modern imaging modalities—echocardiography (including 3D imaging), cardiac magnetic resonance imaging (CMR), and computed tomography (CT)—that are revolutionizing CHD diagnosis and surgical planning. We also encourage submissions on 3D printing and virtual reality applications offering unprecedented opportunities for staff training, preoperative planning, and patient education. Additionally, we welcome studies on novel catheter-based interventions, innovative surgery results, and advanced perioperative management. Furthermore, considering the promise held by next-generation CHD therapies, we look forward to receiving studies on personalized medicine, genetic insights, tissue engineering, and regenerative approaches.

This Special Issue will foster collaboration among clinicians, researchers, and policymakers by highlighting these innovations and acknowledging ongoing challenges. Our goal is to optimize care, improve outcomes, and shape the future of congenital heart disease management.

Prof. Dr. Jacek Kolcz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • congenital heart disease
  • 3D echocardiography
  • cardiac MRI
  • 3D printing
  • virtual/augmented reality
  • catheter-based interventions
  • surgical results
  • tissue engineering
  • regenerative therapies
  • perioperative management

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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21 pages, 1391 KB  
Article
Global Longitudinal Strain as a Sensitive Marker of Left Ventricular Dysfunction in Pediatric Dilated Cardiomyopathy: A Case–Control Study
by Iolanda Muntean, Beatrix-Jullia Hack and Asmaa Carla Hagau
J. Cardiovasc. Dev. Dis. 2025, 12(9), 351; https://doi.org/10.3390/jcdd12090351 - 12 Sep 2025
Viewed by 208
Abstract
Pediatric dilated cardiomyopathy (DCM) is a rare but important cause of heart failure (HF) and a major indication for cardiac transplantation. Early detection of subclinical myocardial dysfunction is essential for risk stratification and management. This study aimed to evaluate left ventricular (LV) systolic [...] Read more.
Pediatric dilated cardiomyopathy (DCM) is a rare but important cause of heart failure (HF) and a major indication for cardiac transplantation. Early detection of subclinical myocardial dysfunction is essential for risk stratification and management. This study aimed to evaluate left ventricular (LV) systolic function in children with DCM using conventional echocardiographic parameters and speckle-tracking echocardiography (STE) and to explore the relationship between deformation indices, clinical severity and biomarkers. Methods: We conducted a case–control study including 29 children diagnosed with DCM and 27 healthy controls matched by age and sex. All participants underwent clinical evaluation, NT-proBNP measurement, and transthoracic echocardiography. LV systolic function was assessed using conventional echocardiographic parameters, while STE was used to measure LV global longitudinal strain (GLS) and strain rate (SR) from all apical views. Results: GLS and SR were significantly reduced in the DCM group across all apical views (Global GLS: −11.13 ± 6.79% vs. −19.98 ± 3.25%, Global SR: −0.74 ± 0.39 s−1 vs. −1.12 ± 0.16 s−1; p < 0.01). GLS strongly correlated with functional indices (LV ejection fraction, shortening fraction, S′ lateral wave), LV end-diastolic diameter Z-score and NT-proBNP (p < 0.05), but not with MAPSE. In the primary model, GLS was associated with NYHA/Ross III–IV (OR 1.54 per 1% increase; 95% CI 1.14–2.07; p = 0.005); adding systolic blood pressure (p = 0.798) or heart rate (p = 0.973) did not materially change the GLS estimate (Δ ≤ 2%). In separate collinearity-avoiding models, LVEF (OR 1.12 per 1% decrease; 95% CI 1.03–1.22; p = 0.009), LVSF (OR 1.19 per 1% decrease; 95% CI 1.04–1.36; p = 0.011), and NT-proBNP (≈OR 1.11 per 100 units; p = 0.013) were also associated with advanced class. ROC analysis showed excellent discrimination for NT-proBNP (AUC 0.948) and GLS (AUC 0.906), and good–excellent performance for LVEF (AUC 0.869) and LVSF (AUC 0.875). Conclusions: Speckle-tracking derived parameters such as GLS and SR are sensitive and clinically relevant markers of LV dysfunction in pediatric DCM. Global longitudinal strain demonstrated a strong association with both clinical and biochemical markers of disease severity, after accounting for heart rate and blood pressure, supporting its integration into routine evaluation and risk stratification in pediatric DCM. Full article
(This article belongs to the Special Issue Congenital Heart Disease: Imaging Diagnosis, Treatment, and Future Challenges)
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Review

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22 pages, 3367 KB  
Review
Multimodal Imaging from Fetal to Adult Life: A Comprehensive Approach to Hypoplastic Left Heart Syndrome (HLHS)
by Sara Moscatelli, Jolanda Sabatino, Isabella Leo, Nunzia Borrelli, Martina Avesani, Giovanni Di Salvo, Claudia Montanaro, Valeria Pergola, Raffaella Motta, Jessica Ielapi, Assunta Di Costanzo, Rosalba De Sarro, Giulia Guglielmi, Irene Cattapan, Gabriella Gaudieri, Leonie Luedke and Marco Alfonso Perrone
J. Cardiovasc. Dev. Dis. 2025, 12(9), 349; https://doi.org/10.3390/jcdd12090349 - 11 Sep 2025
Viewed by 194
Abstract
Hypoplastic Left Heart Syndrome (HLHS) accounts for 2–3% of congenital heart diseases (CHDs). HLHS is characterized by reduced systemic blood flow due to hypoplastic left ventricle (LV) and underdeveloped left-sided cardiac structures. Without a series of staged interventional treatments, HLHS is often fatal, [...] Read more.
Hypoplastic Left Heart Syndrome (HLHS) accounts for 2–3% of congenital heart diseases (CHDs). HLHS is characterized by reduced systemic blood flow due to hypoplastic left ventricle (LV) and underdeveloped left-sided cardiac structures. Without a series of staged interventional treatments, HLHS is often fatal, typically within the first hours or days of life. This manuscript aims to provide a comprehensive overview of the role of echocardiography, cardiovascular magnetic resonance (CMR), and cardiac computed tomography angiography (CCTA) in the optimal management of patients with HLHS. Specifically, it explores the contributions of various non-invasive imaging modalities to the diagnosis, planning of staged palliative interventions, interstage monitoring, and long-term follow-up of HLHS. Furthermore, the advantages and limitations of each imaging technique will be highlighted to aid in clinical decision-making; however, it is important to note that, at present, no universal guidelines exist, and imaging strategies remain largely dependent on individual centre expertise and protocols. Full article
(This article belongs to the Special Issue Congenital Heart Disease: Imaging Diagnosis, Treatment, and Future Challenges)
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