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Open AccessArticle

Strontium- and Zinc-Containing Bioactive Glass and Alginates Scaffolds

1
Dental Physical Sciences Unit, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London E1 4NS, UK
2
Centre for Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts and The London School of Medicine and Dentistry, London E1 2AD, UK
3
Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain 17666, UAE
*
Author to whom correspondence should be addressed.
Bioengineering 2020, 7(1), 10; https://doi.org/10.3390/bioengineering7010010
Received: 30 November 2019 / Revised: 24 December 2019 / Accepted: 31 December 2019 / Published: 13 January 2020
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering)
With an increasingly elderly population, there is a proportionate increase in bone injuries requiring hospitalization. Clinicians are increasingly adopting tissue-engineering methods for treatment due to limitations in the use of autogenous and autologous grafts. The aim of this study was to synthesize a novel, bioactive, porous, mechanically stable bone graft substitute/scaffold. Strontium- and zinc-containing bioactive glasses were synthesized and used with varying amounts of alginate to form scaffolds. Differential scanning calorimetric analysis (DSC), FTIR, XRD, and NMR techniques were used for the characterization of scaffolds. SEM confirmed the adequate porous structure of the scaffolds required for osteoconductivity. The incorporation of the bioactive glass with alginate has improved the compressive strength of the scaffolds. The bioactivity of the scaffolds was demonstrated by an increase in the pH of the medium after the immersion of the scaffolds in a Tris/HCl buffer and by the formation of orthophosphate precipitate on scaffolds. The scaffolds were able to release calcium, strontium and zinc ions in the Tris/HCl buffer, which would have a positive impact on osteogenesis if tested in vivo. View Full-Text
Keywords: bone scaffolds; alginates; bioactive glass; strontium; zinc; composite bone scaffolds; alginates; bioactive glass; strontium; zinc; composite
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Haider, A.; Waseem, A.; Karpukhina, N.; Mohsin, S. Strontium- and Zinc-Containing Bioactive Glass and Alginates Scaffolds. Bioengineering 2020, 7, 10.

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