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Bioengineering, Volume 6, Issue 4

December 2019 - 29 articles

Cover Story: Recent organ-on-chip models recreate physiological and pathological characteristics of the human female reproductive system. Microfluidic design, operating procedures, and adoption of innovative approaches of tissue engineering enable accurately replicating the biochemical and functional activity of these organs, assessing changes in metabolic activity of the specific cell types, and linking exposure to hormonal treatment or exogenous chemical substances with women’s health and fertility. View this paper.
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Articles (29)

  • Article
  • Open Access
44 Citations
7,637 Views
13 Pages

Tequila Agave Bagasse Hydrolysate for the Production of Polyhydroxybutyrate by Burkholderia sacchari

  • Yolanda González-García,
  • Janessa Grieve,
  • Juan Carlos Meza-Contreras,
  • Berenice Clifton-García and
  • José Antonio Silva-Guzman

Tequila agave bagasse (TAB) is the fibrous waste from the Tequila production process. It is generated in large amounts and its disposal is an environmental problem. Its use as a source of fermentable sugars for biotechnological processes is of intere...

  • Review
  • Open Access
85 Citations
13,081 Views
43 Pages

The realization of biomimetic microenvironments for cell biology applications such as organ-on-chip, in vitro drug screening, and tissue engineering is one of the most fascinating research areas in the field of bioengineering. The continuous evolutio...

  • Article
  • Open Access
8 Citations
7,287 Views
16 Pages

Quantitative CPP Evaluation from Risk Assessment Using Integrated Process Modeling

  • Daniel Borchert,
  • Thomas Zahel,
  • Yvonne E. Thomassen,
  • Christoph Herwig and
  • Diego A. Suarez-Zuluaga

Risk assessments (RAs) are frequently conducted to assess the potential effect of process parameters (PPs) on product quality attributes (e.g., a critical quality attribute (CQA)). To evaluate the PPs criticality the risk priority number (RPN) for ea...

  • Article
  • Open Access
25 Citations
7,648 Views
14 Pages

Probing the Antitumor Mechanism of Solanum nigrum L. Aqueous Extract against Human Breast Cancer MCF7 Cells

  • Binbing Ling,
  • Shujun Xiao,
  • Jinha Yang,
  • Ying Wei,
  • Meena K. Sakharkar and
  • Jian Yang

Solanum nigrum L. is one of the major medicinal plants used to treat cancer. However, the functional mechanism of S. nigrum L. extract is still unknown in spite of numerous studies on its active components. In this study, we probed the potential anti...

  • Article
  • Open Access
30 Citations
8,586 Views
14 Pages

X-ray computed tomography (CT) is widely used in clinical practice. The involved ionizing X-ray radiation, however, could increase cancer risk. Hence, the reduction of the radiation dose has been an important topic in recent years. Few-view CT image...

  • Article
  • Open Access
34 Citations
10,847 Views
15 Pages

Corneal Epithelial–Stromal Fibroblast Constructs to Study Cell–Cell Communication in Vitro

  • Tina B. McKay,
  • Dimitrios Karamichos,
  • Audrey E. K. Hutcheon,
  • Xiaoqing Guo and
  • James D. Zieske

Cell–cell communication plays a fundamental role in mediating corneal wound healing following injury or infection. Depending on the severity of the wound, regeneration of the cornea and the propensity for scar development are influenced by the...

  • Review
  • Open Access
27 Citations
8,509 Views
22 Pages

This is a literature teaching resource review for biologically inspired microfluidics courses or exploring the diverse applications of microfluidics. The structure is around key papers and model organisms. While courses gradually change over time, a...

  • Review
  • Open Access
75 Citations
11,639 Views
20 Pages

Biomedical Processing of Polyhydroxyalkanoates

  • Dario Puppi,
  • Gianni Pecorini and
  • Federica Chiellini

The rapidly growing interest on polyhydroxyalkanoates (PHA) processing for biomedical purposes is justified by the unique combinations of characteristics of this class of polymers in terms of biocompatibility, biodegradability, processing properties,...

  • Review
  • Open Access
24 Citations
9,035 Views
18 Pages

Thermoresponsive hydrogels showing biocompatibility and degradability have been under intense investigation for biomedical applications, especially hydrogels composed of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(lactic acid-co-glyc...

  • Article
  • Open Access
11 Citations
5,879 Views
12 Pages

Chlorantraniliprole (CAP) is a widely used insecticide in many areas due to its excellent insecticidal ability and mammalian safety, however, the removal of CAP has not been extensively studied. In this study, a bacterial strain GW13, which is capabl...

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Bioengineering - ISSN 2306-5354