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Toxics, Volume 10, Issue 2

February 2022 - 58 articles

Cover Story: The occurrence of transformation products (TPs) of emerging pollutants has been of potential concern in aquatic environments. Nonetheless, it is unclear how TPs are formed and affect organisms in aquatic ecosystem. Thanking to recent advances in analytics and biotechnology, identification of TPs and their formation mechanisms can be explored by non-target screening (NTS) using high-resolution mass spectrometry (HRMS) and in vivo/vitro bioassay using model organisms. In this review, recent progress in TP research including their exposure and effect assessments is summarized. In particular, the review covers prospective research efforts on TP, such as identification of the products using NTS, and assessment of potential risk. View this paper
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Articles (58)

  • Feature Paper
  • Article
  • Open Access
2 Citations
4,136 Views
20 Pages

28 January 2022

The hepatic xenobiotic metabolizing enzyme flavin-containing monooxygenase 3 (FMO3) has been implicated in the development of cardiometabolic disease primarily due to its enzymatic product trimethylamine-N oxide (TMAO), which has recently been shown...

  • Article
  • Open Access
22 Citations
6,226 Views
20 Pages

28 January 2022

Metal-on-metal (MoM) hip implants made of cobalt chromium (CoCr) alloy have shown early failure compared with other bearing materials. A consequence of the abnormal wear produced by these prostheses is elevated levels of cobalt in the blood of patien...

  • Feature Paper
  • Article
  • Open Access
11 Citations
4,073 Views
17 Pages

In Vitro Cyto- and Genotoxicity Assessment of Antibacterial Paints with Triclosan and Isoborneol

  • Micaela Machado Querido,
  • Fernanda Rosário,
  • Maria João Bessa,
  • Francisca Mendes,
  • José Carlos Teixeira,
  • João Paulo Teixeira and
  • Cristiana Costa Pereira

27 January 2022

Surfaces with antimicrobial properties are gaining notoriety as an efficient method to avoid surface contamination. Self-disinfecting paints are a promising strategy towards cleaner indoor environments by preventing the colonization of walls with mic...

  • Article
  • Open Access
20 Citations
3,986 Views
23 Pages

Proficiency and Interlaboratory Variability in the Determination of Phthalate and DINCH Biomarkers in Human Urine: Results from the HBM4EU Project

  • Hans G. J. Mol,
  • Ingrid Elbers,
  • Claudia Pälmke,
  • Daniel Bury,
  • Thomas Göen,
  • Marta Esteban López,
  • Stefanie Nübler,
  • Vincent Vaccher,
  • Jean-Philippe Antignac and
  • Darina Dvořáková
  • + 6 authors

26 January 2022

A quality assurance/quality control program was implemented in the framework of the EU project HBM4EU to assess and improve the comparability of biomarker analysis and to build a network of competent laboratories. Four rounds of proficiency tests wer...

  • Article
  • Open Access
10 Citations
4,954 Views
13 Pages

Altered Plasma Mitochondrial Metabolites in Persistently Symptomatic Individuals after a GBCA-Assisted MRI

  • DeAunne Denmark,
  • Ilene Ruhoy,
  • Bryan Wittmann,
  • Haleh Ashki and
  • Lorrin M. Koran

26 January 2022

Despite the impressive safety of gadolinium (Gd)-based contrast agents (GBCAs), a small number of patients report the onset of new, severe, ongoing symptoms after even a single exposure—a syndrome termed Gadolinium Deposition Disease (GDD). Mit...

  • Article
  • Open Access
15 Citations
6,186 Views
11 Pages

Determination of Prenatal Substance Exposure Using Meconium and Orbitrap Mass Spectrometry

  • Atakan Hernandez,
  • Valerie Lacroze,
  • Natalia Doudka,
  • Jenny Becam,
  • Carole Pourriere-Fabiani,
  • Bruno Lacarelle,
  • Caroline Solas and
  • Nicolas Fabresse

26 January 2022

The aim of this study was to develop and to validate a toxicological untargeted screening relying on LC-HRMS in meconium including the detection of the four main classes of drugs of abuse (DoA; amphetamines, cannabinoids, opioids and cocaine). The me...

  • Article
  • Open Access
13 Citations
5,828 Views
22 Pages

Developmental Phenotypic and Transcriptomic Effects of Exposure to Nanomolar Levels of 4-Nonylphenol, Triclosan, and Triclocarban in Zebrafish (Danio rerio)

  • Jessica Phillips,
  • Alex S. Haimbaugh,
  • Camille Akemann,
  • Jeremiah N. Shields,
  • Chia-Chen Wu,
  • Danielle N. Meyer,
  • Bridget B. Baker,
  • Zoha Siddiqua,
  • David K. Pitts and
  • Tracie R. Baker

24 January 2022

Triclosan, triclocarban and 4-nonylphenol are all chemicals of emerging concern found in a wide variety of consumer products that have exhibited a wide range of endocrine-disrupting effects and are present in increasing amounts in groundwater worldwi...

  • Feature Paper
  • Review
  • Open Access
25 Citations
7,890 Views
22 Pages

24 January 2022

The scientific community has increasingly focused on forming transformation products (TPs) from environmental organic pollutants. However, there is still a lot of discussion over how these TPs are generated and how harmful they are to living terrestr...

  • Article
  • Open Access
28 Citations
6,543 Views
20 Pages

24 January 2022

Potentially toxic metals (PTMs) in edible marine fish have been widely reported from at least 15 different regions or countries in the literature. This evidently demonstrates the importance of monitoring the PTMs in fish fillets from a human health r...

  • Feature Paper
  • Article
  • Open Access
7 Citations
4,658 Views
15 Pages

E-Liquids from Seven European Countries–Warnings Analysis and Freebase Nicotine Content

  • Patryk Krystian Bębenek,
  • Vinit Gholap,
  • Matthew Halquist,
  • Andrzej Sobczak and
  • Leon Kośmider

23 January 2022

Electronic cigarettes are available in a variety of devices with e-liquids also available in many flavors, and nicotine concentrations, albeit less than 20 mg/mL in Europe. Given the dynamics of these products, it is important to evaluate product con...

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Toxics - ISSN 2305-6304