Search Results (246)

The radiographic appearance of the urinary bladder in guinea pigs (Cavia porcellus) affected by cystitis is poorly characterized. This retrospective case–control study assessed the radiographic characteristics of the urinary bladder (digital abdominal and whole-body radiographs) in 24 healthy guinea pigs and 24 guinea pigs diagnosed with cystitis. Inclusion criteria for the cystitis cohort included presence of clinical signs (hematuria, incontinence, stranguria, abdominal discomfort, apathy, and inappetence), leukocyturia and/or bacteriuria, complemented by right lateral radiographs and either ultrasound or a positive urine culture. Radiographic criteria indicative of cystitis were systematically evaluated using a vertebral bladder score (VBS) expressed in lumbar vertebral units (LVU) and reference marker lines on lateral radiographs to assess urinary bladder distension. Compared to the control group, radiographs of guinea pigs with cystitis demonstrated increased bladder opacity (46% of cases) and solitary uroliths (25%). Bladder height in patients with cystitis exceeded that of healthy counterparts (median: 16.6 vs. 13.0 mm). The VBS in the cystitis group was significantly elevated (median: 1.50 vs. 1.20 LVU). This investigation revealed that enhanced bladder distension and increased bladder opacity, with a VBS surpassing 1.3 LVU, correlated with the presence of cystitis. Full article

Saitama, the titular hero of ONE’s One Punch Man, is a man so absurdly powerful that nothing, and no one, can stand against him. This limitless ability, rather than acting to make a superhero idol of Saitama, has instead reduced his psychological state to that of extreme nihilistic apathy. It is not until Saitama begins to unlock other aspects of his life, including friendship and community, that he begins to see there is more to life than strength. Working within the satirical bounds of the text, which skewers everything from false fulfillment in accolades to false friends to just about every superhero and manga trope in between, Saitama eventually reengages with his life and becomes far more heroic because of it. In the Overview, the text discusses the manga’s origin and explains some of the satirical jabs. In the Heroic Journey, the article takes you through Saitama’s past and current mental state. In the Super Takeaway, the life lesson Saitama’s story can teach us is that even in the face of boredom and a world in which work itself feels obsolete, there remain ways to overcome apathy so long as we are willing to find them for ourselves. Full article

Respect for privacy has been identified as a guiding principle for the development and use of responsible or ethical artificial intelligence (AI), but also as an endangered value in many countries, including those in Africa. Yet, on the African continent, awareness of personal information privacy remains in its early stages, and awareness-raising initiatives are still limited, fragmented, and non-governmental-driven. Given the current global and local enthusiasm surrounding the adoption and development of AI technologies, I examine the key interrelated factors driving the poor digital information privacy awareness and limited awareness-raising in African countries. Key factors include limited digital literacy; the widespread use and reliance on free and freemium services offered by global North digital technology multinationals; the lack of harmonized data protection legislation and regulation across the continent, which facilitates corporate neocolonialism; and the general apathy of many African governments towards privacy awareness-raising, given their own involvement in privacy-violating surveillance. Subsequently, I recommend strategic actions applicable to diverse stakeholders that could contribute towards reinforcing digital information privacy awareness, particularly within the context of the ongoing adoption and anticipated widespread use of AI technologies on the continent. Full article

The world is burgeoning with ever-growing disparities, nation-states are becoming increasingly oppressive with centrist politics, conflicts are intensifying, and climate change is causing natural disasters, which are increasingly displacing families and children. That is, 473 million children worldwide are living in conflict zones today. By the end of 2023, 47.2 million children had been displaced due to conflict and violence, while natural disasters had driven 26.4 million internal displacements, of which 8.8 million were children This article then responds to the uneven landscapes and dominant imaginaries confronted by contemporary childhoods. In doing so, it locates how children bear the burden of adult agendas in the waiting room of the past, present and future. This lends to the analyses of the wider politics that frame childhoods. In response, the article calls for a conceptual turn in childhood studies urging a radical politics of hope rather than the oppressive politics of tomorrow. It proposes a (re-)imagining of just futures for children whereby adults move from apathy towards childhood reparations and think about what might have been stolen from children and what we may owe them. The paper concludes that any imagination of reparative futures cannot be crafted without children. Full article

Parkinson disease (PD) and mood disorders represent two substantial global health burdens that increasingly co-occur as both conditions rise in prevalence worldwide. Diagnosing Parkinson disease in patients with pre-existing mood disorders is clinically challenging due to overlapping symptoms, medication effects, and shared neurobiological mechanisms. Apathy, psychomotor slowing, and fatigue may mimic depressive symptoms, leading to delayed recognition of early parkinsonism. Development of an underlying neurodegenerative disorder could account for some treatment-resistant symptoms or treatment failures if not recognized. Therefore, the identification of PD will change the treatment and management plan significantly. Accurate diagnosis of PD requires a detailed neurologic examination focusing on bradykinesia, rigidity, and resting tremor, supported when appropriate by dopamine transporter imaging (DaT scan) or other emerging biomarkers. Understanding the temporal relationship between psychiatric and motor features helps differentiate prodromal PD from primary mood disorders. Management of patients with both mood disorders and PD integrates dopaminergic replacement therapy for motor symptoms with individualized treatment of psychiatric comorbidities. Levodopa remains the cornerstone for motor control, while dopamine agonists, MAO-B inhibitors, and COMT inhibitors can be added as needed. For depression and anxiety, SSRIs and SNRIs are first-line choices; quetiapine or clozapine are preferred when treatment for psychosis is necessary. Intentional, thoughtful polypharmacy is frequently required. Non-pharmacologic interventions—including cognitive behavioral therapy, structured exercise, and patient–caregiver education—enhance mood, function, and quality of life. Multidisciplinary collaboration between neurology, psychiatry, and allied health professionals is essential for optimal outcomes. This review offers guidance to healthcare providers as well as other interested parties involved in patients with mood disorders who may also be developing or have PD, especially to those who may have limited access to neurologic resources. Full article

Background: Alzheimer’s disease (AD) and mild cognitive impairment (MCI) are traditionally defined by progressive cognitive decline, yet neuropsychiatric symptoms (NPS), including depression, apathy, anxiety, irritability, and sleep disturbances, commonly emerge in the earliest stages. These symptoms often precede measurable memory loss and complicate diagnosis, accelerate disease progression, and substantially increase caregiver burden. Differentiating NPS related to neurodegeneration from primary psychiatric disorders remains a major clinical challenge. Methods: A structured narrative review of peer-reviewed studies (2012–2025) was conducted across PubMed, MEDLINE, Scopus, PsycINFO, CINAHL, and Google Scholar. Evidence was synthesized across epidemiological, clinical, neurobiological, and psychosocial domains to examine NPS prevalence, diagnostic complexity, and treatment approaches in early AD/MCI. Findings Up to 80% of individuals with early AD or MCI exhibit at least one NPS, often before cognitive decline is clinically evident. Non-pharmacologic strategies-caregiver education, behavioral activation, structured routines-remain first-line treatments, while pharmacologic options show modest benefit and safety concerns. Advances in biomarkers, digital health tools, and neurobiological research highlight NPS as potential early indicators of disease onset. Conclusions: Failure to recognize NPS in early AD/MCI contributes to delayed diagnosis, suboptimal care, caregiver stress, and missed opportunities for early intervention. Integrating systematic NPS assessment into diagnostic and care pathways is essential to improving outcomes and advancing therapeutic innovation. Full article

This narrative review integrates longitudinal cohort studies, neuroimaging and biomarker research, and major clinical trials to examine how depression and cognitive decline interact across the dementia continuum. Depression and cognitive impairment frequently co-occur in late life and exhibit substantial clinical and biological overlap. Meta-analytic and large population-based cohort studies consistently show that late-life depression increases the risk of mild cognitive impairment and dementia, with stronger associations observed for vascular dementia than for Alzheimer’s disease. Neurobiological studies implicate cerebrovascular pathology, neuroinflammation, hypothalamic–pituitary–adrenal axis dysregulation, and fronto-subcortical circuit dysfunction as key mechanisms linking depressive symptoms to later cognitive decline. In a subset of older adults, new-onset depression—particularly when accompanied by executive dysfunction, subjective cognitive decline, or high white-matter hyperintensity burden—are associated with an increased likelihood of near-term cognitive decline and dementia, although evidence for a definitive prodromal state remains limited. Depression is also highly prevalent as part of the behavioral and psychological symptoms of dementia, occurring in 30–50% of individuals with Alzheimer’s disease and even higher proportions in dementia with Lewy bodies or frontotemporal dementia. Comorbid depression in dementia accelerates cognitive and functional decline, increases neuropsychiatric burden, and worsens quality of life for patients and caregivers. Therapeutically, antidepressant treatment may confer modest benefits on mood and selected cognitive domains (e.g., processing speed and executive function) in non-demented older adults, whereas in established dementia, antidepressant efficacy is limited. In contrast, cholinesterase inhibitors, memantine, and multimodal non-pharmacological interventions yield small but measurable improvements in depressive or apathy-related symptoms. Emerging disease-modifying therapies for Alzheimer’s disease have demonstrated cognitive benefits, but current trial data provide insufficient evidence regarding effects on depressive symptoms, highlighting an important gap for future research. These findings underscore the need for stage-specific, integrative strategies to address the intertwined trajectories of mood and cognition in aging. Full article

Background: Late-onset depression (LOD) represents a distinct clinical and biological phenotype emerging in the context of global population ageing. This study aims to synthesize current evidence on the epidemiology, risk factors, mechanistic pathways, and therapeutic approaches of LOD, integrating biological, psychological, and social dimensions. Methods: This narrative review synthesizes recent evidence across epidemiology, clinical symptomatology, neurobiology, and treatment. Where conceptually appropriate or empirically overlapping, we incorporate findings from the broader late-life depression (LLD) literature. Results: LOD emerges (as a distinct clinical and biological entity in later life) as a clinically and biologically meaningful presentation of depression in later life, representing a minority of depressive cases. It is defined by prominent apathy, psychomotor slowing, and cognitive impairment, and is closely linked to frailty, medical comorbidity, and heightened dementia risk. Pathophysiological mechanisms converge on vascular, inflammatory, oxidative, and neuroplasticity pathways, while psychosocial adversity further shapes onset and course. Treatment prioritizes efficacy and tolerability amid multiple morbidity; SSRIs and SNRIs are first-line, with pro-dopaminergic or dual-action agents addressing anhedonia and apathy, and neuromodulation or augmentation strategies reserved for resistance. Integrative approaches combining pharmacotherapy, psychotherapy, and lifestyle interventions are essential to optimize outcomes in aging populations. Conclusions: Late-onset depression (is a distinct, biologically and psychosocially driven disorder) represents a biologically and psychosocially enriched subtype in its own within the spectrum of late-life depression, requiring integrated, personalized care. Addressing neurovascular mechanisms, psychosocial adversity, and prevention through coordinated geriatric and psychiatric strategies may improve outcomes in aging populations. Full article

Trinidad and Tobago (T&T) has regional influence in the Caribbean, with a diversified economy focused on energy, manufacturing, and finance compared to the tourism-related economies of most of the other Caribbean islands. Notwithstanding, this has not translated into equitable opportunities for all, specifically for people with disabilities. A lack of disaggregated employment data thwarts effective policy planning for people with disabilities. This research sought to examine the barriers to their employment in T&T. Underpinned by the social model of disability, a concurrent mixed-methods approach was employed. Emanating from interviews with people with disabilities and key informants, challenges to employment access, employer perceptions, and apathy emerged as key themes, together with the underlying issues of a lack of legislation and inequitable access to mainstream education. The survey findings indicated that 64% of employers had never employed people with disabilities, 57% expressed neutrality regarding future employment of such individuals, and 69% had not introduced workplace accommodations. A key recommendation of the study is the establishment of an employer resource centre that assists employers in creating and maintaining inclusive workplace accommodations for people with disabilities. This study is the first in Trinidad and Tobago to examine these research objectives from multiple perspectives. Full article

Background and Clinical Significance: Giant sphenoid wing meningiomas are generally viewed as skull base masses that compress frontal centers and their respective pathways gradually enough to cause a dysexecutive–apathetic syndrome, which can mimic primary neurodegenerative disease. The aim of this report is to illustrate how bedside phenotyping and multimodal imaging can disclose similar clinical presentations as surgically treatable network lesions. Case Presentation: An independent, right-handed older female developed an incremental, two-year decline of her ability to perform executive functions, extreme apathy, lack of instrumental functioning, and a frontal-based gait disturbance, culminating in a first generalized seizure and a newly acquired left-sided upper extremity pyramidal sign. Standardized neuropsychological evaluation revealed a predominant frontal-based dysexecutive profile with intact core language skills, similar to behavioral-variant frontotemporal dementia (bvFTD). MRI demonstrated a large, right fronto-temporo-basal extra-axial tumor attached to the sphenoid wing with homogeneous postcontrast enhancement, significant vasogenic edema within the frontal projection pathways, and a marked midline displacement of structures with an open venous pathway. With the use of a skull-base flattening pterional craniotomy with early devascularization followed by staged internal debulking, arachnoid preserving dissection, and conservative venous preservation, the surgeon accomplished a Simpson Grade I resection. Sequential improvements in the patient’s frontal “re-awakening” were demonstrated through postoperative improvements on standardized stroke, cognitive and functional assessment scales that correlated well with persistent decompression and symmetric ventricles on follow-up images. Conclusions: This case illustrates the possibility of a non-dominant sphenoid wing meningioma resulting in a pseudo-degenerative frontal syndrome and its potential for reversal if recognized as a network lesion and treated with tailored, venous-sparing skull-base surgery. Contrast-enhanced imaging and routine frontal testing in atypical “dementia” presentations may aid in identifying additional patients with potentially surgically remediable cases. Full article

A two-year-old, intact female, domestic fawn-colored dwarf lop rabbit was presented with apathy and anorexia. Clinical examination revealed hypothermia, tachycardia, and abdominal pain. Routine hematology, biochemistry, radiographic and ultrasonographic examinations were performed. Radiographic evaluation demonstrated pneumoperitoneum, generalized small intestinal distention and marked focal dilation of the descending colon by amorphous and partially mineralized material. Ultrasonography confirmed the presence of free gas along with abdominal effusion. Exploratory laparotomy revealed focal perforation of the descending colon associated with mural abscess formation containing fecal material and pus. The severity of the lesions and multiple adhesions to adjacent organs (urinary bladder and uterus) led to the decision for intraoperative euthanasia. This case report describes clinical, imaging and surgical findings of pneumoperitoneum related to septic peritonitis secondary to colonic perforation in a domestic rabbit. Full article

Background/Objectives: Emotion dysregulation is central to many psychiatric disorders. Laboratory-based tasks designed to assess emotion processing and regulation often rely on standardized affective stimuli whose ecological validity remains unclear. We contextualize this study in our broader research program of neurophenomenological reflection of standard paradigms in experimental cognitive psychology. Methods: This study investigates the lived experience of 27 patients with affective disorders as they performed a cognitive-affective task combining working memory demands with exposure to negative emotional images. Phenomenological interviews were used to collect data on their experience of the task. Results: We identified three key experiential domains: whether the stimuli are capable of eliciting a spontaneous emotional response, voluntary construction of an emotional responses, and its temporal dynamics. Patients reported on two alterations in affectivity that are associated with dysregulation: (a) affective enchantment, characterized by intense emotions combined with superstitious appraisal; and (b) disintwinement (a sense of detachment and emotional blunting). Emotional responses exhibited complex unfolding across moment-to-hour timescales, sometimes persisting and blending across trials (impressionability), reflecting clinical phenomena such as rumination. Additionally, patients employed a range of explicit and implicit regulation strategies, many acquired through therapy or long-term coping. Conclusions: Our findings reveal the limitations of rapid, static image-based paradigms in eliciting authentic and spontaneous affectivity in clinical populations, highlighting the need for more ecologically valid experimental designs. Furthermore, inclusion of reports on such subtle affective states as vital feelings in laboratory-based experimental assessments is necessary for a comprehensive understanding of altered phenomenology of affectivity in affective disorders. Full article

Decentralized Autonomous Organizations (DAOs) suffer from critical governance challenges, such as low voter participation, large token holders’ dominance, and inefficient proposal analysis by manual processes. We propose APOLLO (Autonomous Predictive On-Chain Learning Orchestrator), an AI-powered approach that automates the governance lifecycle in order to address these problems. The gemma-3-4b Large Language Model (LLM) in conjunction with Retrieval-Augmented Generation (RAG) powers APOLLO’s multi-agent system, which enhances contextual comprehension of proposals. The system enhances governance by merging real-time on-chain and off-chain data, ensuring adaptive decision-making. Automated proposal writing, logistic regression-based approval probability prediction, and real-time vote outcome analysis with contextual feature-based confidence scores are some of the major advancements. LLM is used to draft proposals and a feedback loop to enrich its knowledge base, reducing whale dominance and voter apathy with a transparent, bias-resistant system. This work demonstrates the revolutionary potential of AI in promoting decentralized governance, paving the way for more effective, inclusive, and dynamic DAO systems. Full article

The Icelandic mutation in the amyloid precursor protein (APP), APP^A673T, has been identified in Icelandic and Scandinavian populations and is associated with a significantly lower risk of developing Alzheimer’s disease (AD). The introduction of the human APP^A673T form led to a reduction in amyloid β-protein (Aβ) production and tau pathology, but the effect of mouse APP^A673T on tau and Aβ pathology is not well studied. We have crossed line 66 (L66) tau transgenic mice that overexpress the P301S aggregation-prone form of tau with C57Bl6/J mice expressing a single-point mutation edited into the murine APP gene via CRISPR-Cas gene editing, known as mAPP^A673T. We have performed ELISA, histopathological, and behavioural analyses of heterozygous male/female L66 and L66 xmAPP^A673T crosses at the age of 6 months to investigate the effect of the murine A673T mutation on tau brain pathology and behavioural deficits in these mice. Using immunohistochemistry, we found only a moderate, yet significant, reduction in mAb 7/51-reactive tau for female L66 x mAPP^A673T compared to L66 mice. Quantification of tau in soluble/insoluble brain homogenate fractions by ELISA confirmed the lack of overt differences between genotypes, as did our extensive behavioural phenotyping using six different paradigms assessing motor function, olfaction, depression/apathy-like behaviour, as well as exploration and sociability. Therefore, the mAPP^A673T mutation has a moderate impact on tau pathology but does not appear to impact motor and neuropsychiatric behaviour in L66 tau transgenic mice. Full article

Background/Objectives: Apathy, characterized by diminished motivation and reduced engagement in goal-directed behavior, is a prevalent concern among older adults, particularly in rural communities where opportunities for meaningful engagement may be limited. This study explores the preliminary impact of an in-person eBook club program on apathy among community-dwelling older adults in Northern British Columbia. Methods: This eight-week pilot single-group, pre-post mixed-methods study combined the use of eReaders to access weekly reading materials with facilitated in-person group discussions designed to foster emotional and social connection. Apathy was assessed using the 3-item Geriatric Depression Scale (GDS-3A) before and after the program. Results: A Wilcoxon signed-rank test revealed a statistically significant reduction in apathy scores (Z = −4.01, p < 0.001), with a large effect size (r = 0.76). While not powered for hypothesis testing, these findings suggest the program may have a meaningful effect. Qualitative analysis of participants who reported higher baseline apathy scores identified three key mechanisms of change: positivity effect, selective pruning of social networks, and adaptive coping, consistent with socioemotional selectivity theory. Conclusions: These preliminary results support the feasibility and potential value of theory-informed, low-cost group reading programs for addressing apathy in older adults and can inform the design of a larger, controlled study. Full article