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Alpha-Cyclodextrin Attenuates the Glycemic and Insulinemic Impact of White Bread in Healthy Male Volunteers

1
Bioresco Ltd., 4054 Basel, Switzerland
2
Gastro Center, 2502 Biel, Switzerland
3
Datagen AG, 3930 Visp, Switzerland
*
Author to whom correspondence should be addressed.
Foods 2020, 9(1), 62; https://doi.org/10.3390/foods9010062
Received: 28 November 2019 / Revised: 18 December 2019 / Accepted: 3 January 2020 / Published: 7 January 2020
(This article belongs to the Section Food Nutrition)
The demonstration of a physiological benefit has recently become an indispensible element of the definition of dietary fibers. In the here-reported pilot study, the effect of alpha-cyclodextrin (alpha-CD) on the postprandial glycemic and insulinemic effect of starch was examined. Twelve fasted, healthy male volunteers received, on three subsequent days, a test breakfast consisting of (A) 100 g fresh white bread (providing 50 g starch) and 250 mL drinking water, (B) the same bread with a supplement of 10 g alpha-CD dissolved in the drinking water, and (C) 25 g alpha-CD dissolved in drinking water. Capillary and venous blood was sampled before the breakfast and in regular intervals for a three-hour period thereafter. Glucose was determined in capillary blood and insulin in the plasma of venous blood samples. Breakfast (A) led to a rapid rise in blood glucose and insulin. In breakfast (B), alpha-CD reduced the areas under the curve of blood glucose and insulin significantly by 59% and 57%, respectively, demonstrating that alpha-CD inhibits and thereby delays starch digestion. Treatment (C) was not associated with a rise of blood glucose. Hence, alpha-CD complies with the current definition of dietary fiber in every respect. View Full-Text
Keywords: alpha-cyclodextrin; dietary fiber; glycemic response; insulinemic response; amylase; digestion alpha-cyclodextrin; dietary fiber; glycemic response; insulinemic response; amylase; digestion
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MDPI and ACS Style

Bär, A.; Diamantis, I.; Venetz, W.P. Alpha-Cyclodextrin Attenuates the Glycemic and Insulinemic Impact of White Bread in Healthy Male Volunteers. Foods 2020, 9, 62.

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