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Volume 8
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10.3390/pr8121576
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Article

Samnamul (Shoots of Aruncus dioicus) Inhibit Adipogenesis by Downregulating Adipocyte-Specific Transcription Factors in 3T3-L1 Adipocytes

by
Ji Yeon Lee
1,2,
Jeong-Yong Park
1,
Hyun Taek Seo
3,
Hyun-A Seong
4,
Yun-Jeong Ji
1,
Seung Eun Lee
1,
Kyung Hye Seo
5,* and
Hyung Don Kim
1,4,*
1
Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, Eumsung 27709, Korea
2
Department of Food Science and Biotechnology, Chungbuk National University, Chungbuk 28644, Korea
3
Wild Vegetables Research Institute, Gangwondo Agricultural Research and Extension Services, Pyeongchang 25300, Korea
4
Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 28644, Korea
5
Development of Horticultural Crop Research, National Institute of Horticultural & Herbal Science, RDA, Jeonju 55365, Korea
*
Authors to whom correspondence should be addressed.
Processes 2020, 8(12), 1576; https://doi.org/10.3390/pr8121576
Submission received: 27 October 2020 / Revised: 19 November 2020 / Accepted: 26 November 2020 / Published: 29 November 2020
(This article belongs to the Section Food Process Engineering)
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Abstract

Adipocyte-specific transcription factors and antioxidants are considered the best target of obesity. Aruncus dioicus var. kamtschaticus (A. dioicus, Samnamul) is easily available owing to edible and inexpensive. However, the anti-adipogenic effects of the underlying mechanism of A. dioicus extract (ADE) have not yet been reported. In the present study, we evaluate anti-adipogenic pathway in 3T3-L1 adipocytes, antioxidant activities and quantified phenolics using high-performance liquid chromatography of ADE. The results revealed ADE had reduced adipocyte differentiation (0.72-fold vs. MDI (media of differentiation) control), triglyceride (TG; 0.50-fold vs. MDI control, p < 0.001), and total cholesterol contents (0.77-fold vs. MDI control) by regulating adipocyte-specific transcription factors (C/EBPα, PPARγ, and SREBP1) and their downstream mRNA (AdipoQ, Ap2, SREBP1-c, and FAS) levels. Furthermore, ADE has higher total phenol and flavonoid contents and scavenging assay in the DPPH and ABTS+. In particularly, ADE contains chlorogenic acid (7.04 mg/kg), caffeic acid (20.14 mg/kg), ferulic acid (1.74 mg/kg), veratric acid (29.31 mg/kg), cinnamic acid (4.70 mg/kg), and quercetin (4.18 mg/kg). In conclusion, since these phenols, especially quercetin, in the ADE appear to reduce differentiation, TG and cholesterol content by regulating adipocyte-specific transcription factors in adipocytes, ADE has the potential to be developed into a new antioxidant and anti-obesity therapeutics.
Keywords: Aruncus dioicus; adipocytes; adipogenesis; lipogenesis; phenolics Aruncus dioicus; adipocytes; adipogenesis; lipogenesis; phenolics

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MDPI and ACS Style

Lee, J.Y.; Park, J.-Y.; Seo, H.T.; Seong, H.-A.; Ji, Y.-J.; Lee, S.E.; Seo, K.H.; Kim, H.D. Samnamul (Shoots of Aruncus dioicus) Inhibit Adipogenesis by Downregulating Adipocyte-Specific Transcription Factors in 3T3-L1 Adipocytes. Processes 2020, 8, 1576. https://doi.org/10.3390/pr8121576

AMA Style

Lee JY, Park J-Y, Seo HT, Seong H-A, Ji Y-J, Lee SE, Seo KH, Kim HD. Samnamul (Shoots of Aruncus dioicus) Inhibit Adipogenesis by Downregulating Adipocyte-Specific Transcription Factors in 3T3-L1 Adipocytes. Processes. 2020; 8(12):1576. https://doi.org/10.3390/pr8121576

Chicago/Turabian Style

Lee, Ji Yeon, Jeong-Yong Park, Hyun Taek Seo, Hyun-A Seong, Yun-Jeong Ji, Seung Eun Lee, Kyung Hye Seo, and Hyung Don Kim. 2020. "Samnamul (Shoots of Aruncus dioicus) Inhibit Adipogenesis by Downregulating Adipocyte-Specific Transcription Factors in 3T3-L1 Adipocytes" Processes 8, no. 12: 1576. https://doi.org/10.3390/pr8121576

APA Style

Lee, J. Y., Park, J.-Y., Seo, H. T., Seong, H.-A., Ji, Y.-J., Lee, S. E., Seo, K. H., & Kim, H. D. (2020). Samnamul (Shoots of Aruncus dioicus) Inhibit Adipogenesis by Downregulating Adipocyte-Specific Transcription Factors in 3T3-L1 Adipocytes. Processes, 8(12), 1576. https://doi.org/10.3390/pr8121576

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