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Children, Volume 9, Issue 5

May 2022 - 184 articles

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Cover Story: Developmental Language Disorder (DLD) affects roughly 8% of school-aged children and is thought to be caused by complex interactions between genetic variants and environmental factors. A handful of candidate genes have been implicated in DLD populations through linkage and association studies, yet the search for further pathogenic variants remains elusive. Understanding the genetic architecture of DLD is critical in order to decipher new genetic associations. This article outlines the DLD phenotype and reviews recently identified gene pathways for DLD. View this paper

Articles (184)

  • Article
  • Open Access
15 Citations
3,697 Views
9 Pages

Clinical Manifestations of Neonatal Hyperbilirubinemia Are Related to Alterations in the Gut Microbiota

  • Xueli Zhang,
  • Shujuan Zeng,
  • Guoqiang Cheng,
  • Liufang He,
  • Mingqiu Chen,
  • Mingbang Wang,
  • Wenhao Zhou,
  • Huixian Qiu and
  • Zhangxing Wang

Background and purpose: Neonatal hyperbilirubinemia, also known as neonatal jaundice, is a common and frequent clinical condition with a complex etiology that can lead to brain damage in severe cases. Early recognition of hyperbilirubinemia and timel...

  • Article
  • Open Access
6 Citations
3,582 Views
17 Pages

Anastatica hierochuntica (A. hierochuntica) is a plant that originates from Middle Eastern countries. This herb is commonly consumed by pregnant women to ease the process of childbirth. However, consumption of A. hierochuntica during the prenatal per...

  • Article
  • Open Access
2 Citations
2,486 Views
8 Pages

Vitamin D and Forearm Fractures in Children Preliminary Findings: Risk Factors and Correlation between Low-Energy and High-Energy Fractures

  • Sinisa Ducic,
  • Filip Milanovic,
  • Mikan Lazovic,
  • Bojan Bukva,
  • Goran Djuricic,
  • Vladimir Radlovic and
  • Dejan Nikolic

Background: The forearm is the most common fracture site in childhood, accounting for every fourth pediatric fracture. It is well described that vitamin D is involved in the regulation of bone mineralization and skeletal homeostasis by the regulation...

  • Article
  • Open Access
4 Citations
3,053 Views
11 Pages

One Year of Lung Ultrasound in Children with SARS-CoV-2 Admitted to a Tertiary Referral Children’s Hospital: A Retrospective Study during 2020–2021

  • Anna Maria Musolino,
  • Valentina Ferro,
  • Maria Chiara Supino,
  • Elena Boccuzzi,
  • Simona Scateni,
  • Serena Sinibaldi,
  • Laura Cursi,
  • Paolo Maria Salvatore Schingo,
  • Antonino Reale and
  • Andrea Campana
  • + 3 authors

During the COVID-19 pandemic, the lung ultrasound (LU) turned out to be a pivotal tool to study the lung involvement in the adult population, but the same was not well evaluated in children. We detected the LU patterns through an integrated approach...

  • Article
  • Open Access
5 Citations
4,159 Views
9 Pages

Does Risser Casting for Adolescent Idiopathic Scoliosis Still Have a Role in the Treatment of Curves Larger Than 40°? A Case Control Study with Bracing

  • Giovanni Andrea La Maida,
  • Enrico Gallazzi,
  • Donata Rita Peroni,
  • Alfonso Liccardi,
  • Andrea Della Valle,
  • Marcello Ferraro,
  • Davide Cecconi and
  • Bernardo Misaggi

Background: The most common conservative treatment for Adolescent Idiopathic Scoliosis (AIS) is bracing. However, several papers questioned the effectiveness of bracing for curves between 40° and 50° Cobb: the effectiveness in preventing curv...

  • Case Report
  • Open Access
12 Citations
5,919 Views
9 Pages

Menke–Hennekam Syndrome: A Literature Review and a New Case Report

  • Aurora Sima,
  • Roxana Elena Smădeanu,
  • Anca Angela Simionescu,
  • Florina Nedelea,
  • Andreea-Maria Vlad and
  • Cristina Becheanu

Background: Menke–Hennekam syndrome (MHS) is a rare and recently described syndrome consecutive to the variants in exon 30 or 31 in CREBBP (CREB-binding protein gene). The CREB-binding protein (CREBBP) and EP300 genes are two commonly expressed...

  • Article
  • Open Access
14 Citations
6,141 Views
12 Pages

Idiopathic scoliosis affects a severe number of children. Their quality of life and development are also disturbed. Some therapeutic strategies have been developed to control illness progression and to optimize the quality of life. In this perspectiv...

  • Article
  • Open Access
8 Citations
2,877 Views
8 Pages

Life Quality of Children Affected by Cleft Lip Palate and Alveolus (CLPA)

  • Marco Pasini,
  • Irene Cagidiaco,
  • Eleonora Fambrini,
  • Marco Miceli and
  • Elisabetta Carli

The aim of this study was to investigate the quality of life of children and adolescents affected by cleft lip, palate and alveolus (CLPA) in the Italian population after a tailored treatment dental program. A prospective study was conducted with sub...

  • Article
  • Open Access
3 Citations
4,089 Views
14 Pages

Cognitive Profiles of Adolescent Inpatients with Substance Use Disorder

  • Angelika Beate Christiane Becker,
  • Luisa Marie Lüken,
  • Lea Kelker,
  • Martin Holtmann,
  • Monika Daseking and
  • Tanja Legenbauer

The prevalence of substance abuse is high during adolescence, and several studies have linked the use of alcohol and cannabis in adolescence to different cognitive impairments. To investigate whether specific cognitive deficits can be observed in ado...

  • Article
  • Open Access
17 Citations
23,518 Views
12 Pages

Transcranial Photobiomodulation for the Treatment of Children with Autism Spectrum Disorder (ASD): A Retrospective Study

  • Stefano Pallanti,
  • Michele Di Ponzio,
  • Eleonora Grassi,
  • Gloria Vannini and
  • Gilla Cauli

Children with Autism Spectrum Disorder (ASD) face several challenges due to deficits in social function and communication along with restricted patterns of behaviors. Often, they also have difficult-to-manage and disruptive behaviors. At the moment,...

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