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Children, Volume 7, Issue 2

February 2020 - 7 articles

Cover Story: Acute promyelocytic leukemia (APL) is a rare disease accounting for only 5%–10% of pediatric acute myeloid leukemia (AML) and fewer than 1000 cases occur annually in the United States across all age groups. Characterized by t (15; 17), with a resultant PML-RARA gene fusion driving leukemia development, advances in therapy have improved outcomes for APL significantly in the past several decades, now making APL the most curable form of AML in both children and adults. Cure rates in APL are now comparable to pediatric B-lymphoid leukemias. The success of APL treatment is due, in part, to the breadth of understanding of the driver PML-RARA mutation as well as collaborative efforts to quickly introduce and maximize the benefit of new therapies. Here, we review the presentation, clinical features, pathogenesis, and treatment advances in pediatric APL. View this paper.

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Articles (7)

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Article

8 Citations

6,010 Views

15 Pages

The Profile, Health Seeking Behavior, Referral Patterns, and Outcome of Outborn Neonates Admitted to a District and Regional Hospital in the Upper West Region of Ghana: A Cross-Sectional Study

Edem M. A. Tette,
Benjamin Demah Nuertey,
Emmanuel A. Azusong and
Naa Barnabas Gandau

Children2020, 7(2), 15;https://doi.org/10.3390/children7020015

18 February 2020

Neonatal mortality is the major contributor to under-five mortality rates in many low and middle income countries. We examined the health practices, care-seeking behavior, and referral of sick outborn neonates to a district and regional hospital in t...

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Review

20 Citations

7,913 Views

15 Pages

Harnessing T Cells to Target Pediatric Acute Myeloid Leukemia: CARs, BiTEs, and Beyond

Rebecca Epperly,
Stephen Gottschalk and
Mireya Paulina Velasquez

Children2020, 7(2), 14;https://doi.org/10.3390/children7020014

17 February 2020

Outcomes for pediatric patients with acute myeloid leukemia (AML) remain poor, highlighting the need for improved targeted therapies. Building on the success of CD19-directed immune therapy for acute lymphocytic leukemia (ALL), efforts are ongoing to...

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Article

38 Citations

4,824 Views

13 Pages

Prevalence and Selected Sociodemographic of Movement Behaviors in Schoolchildren from Low- and Middle-Income Families in Nanjing, China: A Cross-Sectional Questionnaire Survey

Si-Tong Chen and
Jin Yan

Children2020, 7(2), 13;https://doi.org/10.3390/children7020013

13 February 2020

Background: To investigate the prevalence of meeting the 24-h movement guidelines and its sociodemographic correlates in youth from low- and middle-income families (LMIFs) in Nanjing, China. Methods: Cross-sectional data on moderate to vigorous physi...

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Review

30 Citations

10,809 Views

15 Pages

New and Emerging Targeted Therapies for Pediatric Acute Myeloid Leukemia (AML)

Jing Chen and
Chana L. Glasser

Children2020, 7(2), 12;https://doi.org/10.3390/children7020012

10 February 2020

The relapse rate for children with acute myeloid leukemia (AML) remains high despite advancements in risk classification, multi-agent chemotherapy intensification, stem cell transplantation, and supportive care guidelines. Prognosis for this subgroup...

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Review

31 Citations

7,642 Views

11 Pages

Advances in Pediatric Acute Promyelocytic Leukemia

Shannon E. Conneely and
Alexandra M. Stevens

Children2020, 7(2), 11;https://doi.org/10.3390/children7020011

2 February 2020

Acute promyelocytic leukemia (APL) is a rare disease accounting for only 5%–10% of pediatric acute myeloid leukemia (AML) and fewer than 1000 cases occur annually in the United States across all age groups. Characterized by t (15; 17), with a resulta...

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Article

11 Citations

4,768 Views

11 Pages

Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

Teodoro Durá-Travé,
Fidel Gallinas-Victoriano,
Diego Mauricio Peñafiel-Freire,
María Urretavizcaya-Martinez,
Paula Moreno-González and
María Jesús Chueca-Guindulain

Children2020, 7(2), 10;https://doi.org/10.3390/children7020010

1 February 2020

Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with se...

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Brief Report

11 Citations

8,818 Views

6 Pages

Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants

Zlatan Zvizdic,
Irmina Sefic Pasic,
Amra Dzananovic,
Nedzad Rustempasic,
Emir Milisic,
Asmir Jonuzi and
Semir Vranic

Children2020, 7(2), 9;https://doi.org/10.3390/children7020009

23 January 2020

Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency associated with prematurity. Timely diagnosis and adequate treatment are crucial to reduce the morbidity and mortality of the affected infants....

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