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Children, Volume 7, Issue 2

2020 February - 7 articles

Cover Story: Acute promyelocytic leukemia (APL) is a rare disease accounting for only 5%–10% of pediatric acute myeloid leukemia (AML) and fewer than 1000 cases occur annually in the United States across all age groups. Characterized by t (15; 17), with a resultant PML-RARA gene fusion driving leukemia development, advances in therapy have improved outcomes for APL significantly in the past several decades, now making APL the most curable form of AML in both children and adults. Cure rates in APL are now comparable to pediatric B-lymphoid leukemias. The success of APL treatment is due, in part, to the breadth of understanding of the driver PML-RARA mutation as well as collaborative efforts to quickly introduce and maximize the benefit of new therapies. Here, we review the presentation, clinical features, pathogenesis, and treatment advances in pediatric APL. View this paper.
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Articles (7)

  • Article
  • Open Access
10 Citations
6,418 Views
15 Pages

18 February 2020

Neonatal mortality is the major contributor to under-five mortality rates in many low and middle income countries. We examined the health practices, care-seeking behavior, and referral of sick outborn neonates to a district and regional hospital in t...

  • Review
  • Open Access
22 Citations
8,428 Views
15 Pages

Harnessing T Cells to Target Pediatric Acute Myeloid Leukemia: CARs, BiTEs, and Beyond

  • Rebecca Epperly,
  • Stephen Gottschalk and
  • Mireya Paulina Velasquez

17 February 2020

Outcomes for pediatric patients with acute myeloid leukemia (AML) remain poor, highlighting the need for improved targeted therapies. Building on the success of CD19-directed immune therapy for acute lymphocytic leukemia (ALL), efforts are ongoing to...

(This article belongs to the Special Issue Pediatric Acute Myeloid Leukemia: Current Management and Future Directions)
  • Article
  • Open Access
41 Citations
5,208 Views
13 Pages

13 February 2020

Background: To investigate the prevalence of meeting the 24-h movement guidelines and its sociodemographic correlates in youth from low- and middle-income families (LMIFs) in Nanjing, China. Methods: Cross-sectional data on moderate to vigorous physi...

(This article belongs to the Section Global Pediatric Health)
  • Review
  • Open Access
31 Citations
11,431 Views
15 Pages

10 February 2020

The relapse rate for children with acute myeloid leukemia (AML) remains high despite advancements in risk classification, multi-agent chemotherapy intensification, stem cell transplantation, and supportive care guidelines. Prognosis for this subgroup...

(This article belongs to the Special Issue Pediatric Acute Myeloid Leukemia: Current Management and Future Directions)
  • Review
  • Open Access
36 Citations
8,205 Views
11 Pages

Advances in Pediatric Acute Promyelocytic Leukemia

  • Shannon E. Conneely and
  • Alexandra M. Stevens

2 February 2020

Acute promyelocytic leukemia (APL) is a rare disease accounting for only 5%–10% of pediatric acute myeloid leukemia (AML) and fewer than 1000 cases occur annually in the United States across all age groups. Characterized by t (15; 17), with a resulta...

(This article belongs to the Special Issue Pediatric Acute Myeloid Leukemia: Current Management and Future Directions)
  • Article
  • Open Access
14 Citations
5,075 Views
11 Pages

Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

  • Teodoro Durá-Travé,
  • Fidel Gallinas-Victoriano,
  • Diego Mauricio Peñafiel-Freire,
  • María Urretavizcaya-Martinez,
  • Paula Moreno-González and
  • María Jesús Chueca-Guindulain

1 February 2020

Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with se...

  • Brief Report
  • Open Access
15 Citations
9,450 Views
6 Pages

Bowel Dilatation on Initial Plane Abdominal Radiography May Help to Assess the Severity of Necrotizing Enterocolitis in Preterm Infants

  • Zlatan Zvizdic,
  • Irmina Sefic Pasic,
  • Amra Dzananovic,
  • Nedzad Rustempasic,
  • Emir Milisic,
  • Asmir Jonuzi and
  • Semir Vranic

23 January 2020

Background: Necrotizing enterocolitis (NEC) is the most common life-threatening gastrointestinal emergency associated with prematurity. Timely diagnosis and adequate treatment are crucial to reduce the morbidity and mortality of the affected infants....

(This article belongs to the Section Pediatric Surgery)
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Children - ISSN 2227-9067