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Advances in Pediatric Acute Promyelocytic Leukemia

Department of Pediatric Hematology/Oncology, Texas Children’s Cancer Center, Baylor College of Medicine, Fannin Street, Houston, TX 77030, USA
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Children 2020, 7(2), 11; https://doi.org/10.3390/children7020011
Received: 9 January 2020 / Revised: 25 January 2020 / Accepted: 27 January 2020 / Published: 2 February 2020
Acute promyelocytic leukemia (APL) is a rare disease accounting for only 5%–10% of pediatric acute myeloid leukemia (AML) and fewer than 1000 cases occur annually in the United States across all age groups. Characterized by t (15; 17), with a resultant PML-RARA gene fusion driving leukemia development, advances in therapy have improved outcomes for APL significantly in the past several decades, now making APL the most curable form of AML in both children and adults. Cure rates in APL are now comparable to pediatric B-lymphoid leukemias. The success of APL treatment is due, in part, to the breadth of understanding of the driver PML-RARA mutation as well as collaborative efforts to quickly introduce and maximize the benefit of new therapies. Here, we review the presentation, clinical features, pathogenesis, and treatment advances in pediatric APL. View Full-Text
Keywords: t (15; 17); acute myeloid leukemia; arsenic trioxide; all-trans retinoic acid; outcome; pediatric; PML-RARA; ATRA t (15; 17); acute myeloid leukemia; arsenic trioxide; all-trans retinoic acid; outcome; pediatric; PML-RARA; ATRA
MDPI and ACS Style

Conneely, S.E.; Stevens, A.M. Advances in Pediatric Acute Promyelocytic Leukemia. Children 2020, 7, 11.

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