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Open AccessArticle

Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity

Department of Pediatrics, School of Medicine, University of Navarra, 31008 Pamplona, Spain
Department of Pediatrics, Navarra Hospital Complex, 31008 Pamplona, Spain
Navarra Institute for Health Research (IdisNA), 31008 Pamplona, Spain
Author to whom correspondence should be addressed.
Children 2020, 7(2), 10;
Received: 15 November 2019 / Revised: 11 January 2020 / Accepted: 22 January 2020 / Published: 1 February 2020
Background/Objectives. Obesity is associated with cardiometabolic risk factors and with Vitamin D deficiency. The aim of this study was to examine the relationship between 25(OH)D concentrations and cardiometabolic risk factors in adolescents with severe obesity. Subjects/Methods. A cross-sectional clinical assessment (body mass index, fat mass index, fat-free mass index, waist-to-height ratio, and blood pressure) and metabolic study (triglycerides, total cholesterol, HDL-C, LDL-C, glucose, insulin, HOMA-IR, leptin, calcium, phosphorous, calcidiol, and PTH) were carried out in 236 adolescents diagnosed with severe obesity (BMI z-score > 3.0, 99th percentile), aged 10.2–15.8 years. The criteria of the US Endocrine Society were used for the definition of Vitamin D status. Results. Subjects with Vitamin D deficiency had significantly elevated values (p < 0.05) for BMI z-score, waist circumference, waist z-score, body fat percentage, fat mass index, systolic and diastolic blood pressure, total cholesterol, triglycerides, LDL-C, insulin, HOMA-IR, leptin, and PTH than subjects with normal Vitamin D status. There was a significant negative correlation (p < 0.05) of serum 25(OH)D levels with body fat percentage, FMI, systolic BP, total cholesterol, triglyceride, LDL-C, glucose, insulin, HOMA-IR, leptin, and PTH. Conclusions. Low Vitamin D levels in adolescents with severe obesity were significantly associated with some cardiometabolic risk factors, including body mass index, waist circumference, fat mass index, high blood pressure, impaired lipid profile, and insulin resistance. View Full-Text
Keywords: adolescents; severe obesity; cardiometabolic risks factors; Vitamin D adolescents; severe obesity; cardiometabolic risks factors; Vitamin D
MDPI and ACS Style

Durá-Travé, T.; Gallinas-Victoriano, F.; Peñafiel-Freire, D.M.; Urretavizcaya-Martinez, M.; Moreno-González, P.; Chueca-Guindulain, M.J. Hypovitaminosis D and Cardiometabolic Risk Factors in Adolescents with Severe Obesity. Children 2020, 7, 10.

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