Table of Contents
Biomedicines, Volume 5, Issue 3 (September 2017)
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Cover Story (view full-size image) Illustrated is the concept of aptamer siRNA chimeras – AsiCs, therapeutic RNAs that specifically [...] Read more. Illustrated is the concept of aptamer siRNA chimeras – AsiCs, therapeutic RNAs that specifically knock down disease-associated genes in malignant cells. AsiCs bind through their aptamer part (red) to a specific target molecule on a malignant cell, and enter the cell cytosol by endocytosis where they are recognized by the RNAi machinery. As a result, messenger-RNA molecules matching the siRNA of the AsiC will be cleaved, leading to a reduced expression of the related gene (e.g. an oncogene). View this paper