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Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects

Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
Molecular & Cellular Biology Program, Holden Comprehensive Cancer Center, Radiation Oncology, Abboud Cardiovascular Research Center, and Environmental Health Sciences Research Center (EHSRC), University of Iowa, Iowa City, IA 52242, USA
Author to whom correspondence should be addressed.
Biomedicines 2017, 5(3), 45;
Received: 2 July 2017 / Revised: 2 August 2017 / Accepted: 3 August 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Engineering Aptamers for Biomedical Applications)
Synthetic nucleic acid ligands (aptamers) have emerged as effective delivery tools for many therapeutic oligonucleotide-based drugs, including small interfering RNAs (siRNAs). In this review, we summarize recent progress in the aptamer selection technology that has made possible the identification of cell-specific, cell-internalizing aptamers for the cell-targeted delivery of therapeutic oligonucleotides. In addition, we review the original, proof-of-concept aptamer-siRNA delivery studies and discuss recent advances in aptamer-siRNA conjugate designs for applications ranging from cancer therapy to the development of targeted antivirals. Challenges and prospects of aptamer-targeted siRNA drugs for clinical development are further highlighted. View Full-Text
Keywords: aptamers; RNA interference; targeted therapy aptamers; RNA interference; targeted therapy
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MDPI and ACS Style

Kruspe, S.; Giangrande, P.H. Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects. Biomedicines 2017, 5, 45.

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