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Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects

1
Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
2
Molecular & Cellular Biology Program, Holden Comprehensive Cancer Center, Radiation Oncology, Abboud Cardiovascular Research Center, and Environmental Health Sciences Research Center (EHSRC), University of Iowa, Iowa City, IA 52242, USA
*
Author to whom correspondence should be addressed.
Biomedicines 2017, 5(3), 45; https://doi.org/10.3390/biomedicines5030045
Received: 2 July 2017 / Revised: 2 August 2017 / Accepted: 3 August 2017 / Published: 9 August 2017
(This article belongs to the Special Issue Engineering Aptamers for Biomedical Applications)
Synthetic nucleic acid ligands (aptamers) have emerged as effective delivery tools for many therapeutic oligonucleotide-based drugs, including small interfering RNAs (siRNAs). In this review, we summarize recent progress in the aptamer selection technology that has made possible the identification of cell-specific, cell-internalizing aptamers for the cell-targeted delivery of therapeutic oligonucleotides. In addition, we review the original, proof-of-concept aptamer-siRNA delivery studies and discuss recent advances in aptamer-siRNA conjugate designs for applications ranging from cancer therapy to the development of targeted antivirals. Challenges and prospects of aptamer-targeted siRNA drugs for clinical development are further highlighted. View Full-Text
Keywords: aptamers; RNA interference; targeted therapy aptamers; RNA interference; targeted therapy
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Kruspe, S.; Giangrande, P.H. Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects. Biomedicines 2017, 5, 45.

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