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Biomedicines 2017, 5(3), 35;

Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease

Division of Hematology and Oncology, University of Kansas Cancer Center, Kansas City, KS 66205, USA
Division of Hematology, Oncology and Blood and Marrow Transplantation, Children’s Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA 90027, USA
Section of Blood and Marrow Transplantation and Cellular Therapy, University of Alabama at Birmingham, Brimingham, AL 35294, USA
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 23 May 2017 / Revised: 15 June 2017 / Accepted: 18 June 2017 / Published: 26 June 2017
(This article belongs to the Special Issue Cell Therapy for the Treatment of GVHD)
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Graft versus host disease (GVHD) represents a major complication of allogeneic hematopoietic stem cell transplantation (allo HCT). Graft cellular manipulation has been used to mitigate the risk of GVHD. The αβ T cells are considered the primary culprit for causing GVHD therefore depletion of this T cell subset emerged as a promising cellular manipulation strategy to overcome the human leukocyte antigen (HLA) barrier of haploidentical (haplo) HCT. This approach is also being investigated in HLA-matched HCT. In several studies, αβ T cell depletion HCT has been performed without pharmacologic GVHD prophylaxis, thus unleashing favorable effect of donor’s natural killer cells (NK) and γδ T cells. This article will discuss the evolution of this method in clinical practice and the clinical outcome as described in different clinical trials. View Full-Text
Keywords: αβ T cells; haploidentical transplant; graft versus host disease αβ T cells; haploidentical transplant; graft versus host disease

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Abdelhakim, H.; Abdel-Azim, H.; Saad, A. Role of αβ T Cell Depletion in Prevention of Graft versus Host Disease. Biomedicines 2017, 5, 35.

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