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Biomedicines, Volume 13, Issue 9

September 2025 - 275 articles

Cover Story: Iron is indispensable for life yet toxic in excess. Iron utilization is essential to normal physiologic processes across cell types. This paper explores the molecular mechanisms that maintain systemic iron balance and how their disruption leads to multi-organ disease. We outline iron's "lifecycle", key regulatory pathways, and the consequences of their failure, along with iron’s impact on systems including bone marrow, CNS, liver, kidneys, gonads, and endocrine tissues. In each of these, the dangers of overload are described, linking molecular missteps to diverse and potentially chronic syndromes. Finally, emerging therapies such as gene editing and mimetics aimed at restoring iron equilibrium are also discussed. View this paper
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Articles (275)

  • Review
  • Open Access
1,158 Views
16 Pages

Adrenal Incidentaloma: From Silent Diagnosis to Clinical Challenge

  • Alexandra Mirica,
  • Dana-Mihaela Tilici,
  • Diana Loreta Paun,
  • Ana Maria Arnautu,
  • Victor Nimigean and
  • Sorin Paun

19 September 2025

The widespread use of advanced imaging techniques has led to a rising incidence of adrenal incidentalomas (AIs), asymptomatic adrenal masses discovered during imaging for non-adrenal-related conditions. AIs represent a diagnostic and therapeutic chal...

  • Article
  • Open Access
744 Views
11 Pages

Th2 Suppression Through Antigen Liver Expression Using mRNA-LNP Technology

  • Kazunori Arai,
  • Hanae Toyonaga,
  • Lei Cheng and
  • Hirotsugu Tanaka

19 September 2025

Background: Messenger RNA-lipid nanoparticle (mRNA-LNP) is a cutting-edge nucleic acid intracellular delivery technology. Although the clinical use of the mRNA vaccine is being actively developed, the use of mRNA-LNP technology in common diseases suc...

  • Article
  • Open Access
1,020 Views
15 Pages

Iron Deficiency in Heart Failure: From ESC Guidelines to Clinical Practice at a Romanian Hospital

  • Oana Sirbu,
  • Andreea Tirnoveanu,
  • Raluca Ecaterina Haliga,
  • Victorita Sorodoc,
  • Miruna Sava,
  • Cristina Bologa,
  • Ovidiu Rusalim Petris,
  • Bianca Codrina Morarasu,
  • Alexandra Diana Diaconu and
  • Alexandr Ceasovschih
  • + 7 authors

19 September 2025

Background: Iron deficiency (ID) is a frequent comorbidity in heart failure (HF), associated with reduced functional capacity and poor prognosis. Although the European Society of Cardiology (ESC) guidelines recommend systematic screening and intraven...

  • Article
  • Open Access
716 Views
18 Pages

18 September 2025

Purpose: The venous-to-arterial carbon dioxide partial pressure difference [P(v-a)CO2] reflects the adequacy of tissue perfusion, with elevated values suggesting impaired clearance of CO2. While its prognostic role has been investigated in septic sho...

  • Review
  • Open Access
1 Citations
1,344 Views
16 Pages

Tolerability and Shared Decision-Making in the Hormonal Management of Endometriosis-Associated Pain

  • Diogo Pinto da Costa Viana,
  • Leonardo Jacobsen,
  • Igor Padovesi,
  • Ana Comin,
  • Eline Lobo de Souza Correia,
  • Daniela Da Maia Fernandes and
  • Ana Carolina Pires Dias

18 September 2025

Background: The management of endometriosis-associated pain has traditionally focused on analgesic efficacy. However, with high-level evidence demonstrating therapeutic equivalence among principal hormonal classes, the paradigm has shifted towards a...

  • Article
  • Open Access
1 Citations
1,324 Views
16 Pages

Sex Differences in MASLD After Age 50: Presentation, Diagnosis, and Clinical Implications

  • Ilaria Milani,
  • Maria Eugenia Parrotta,
  • Luca Colangeli,
  • Marianna Chinucci,
  • Simonetta Palleschi,
  • Barbara Rossi,
  • Paolo Sbraccia,
  • Alessandro Mantovani,
  • Frida Leonetti and
  • Valeria Guglielmi
  • + 1 author

18 September 2025

Background: Age over 50, menopause, obesity and type 2 diabetes (T2D) are key risk factors for Metabolic dysfunction-associated steatotic liver disease (MASLD). This observational study aimed to assess sex differences in anthropometric and clinical p...

  • Article
  • Open Access
882 Views
17 Pages

18 September 2025

Background/Objectives: Mesenchymal stem cells (MSCs) offer promising prospects for novel treatment modalities in cellular therapies and artificial organ production. Despite a surge in artificial tissue research, there is a dearth of comprehensive stu...

  • Review
  • Open Access
1,029 Views
17 Pages

Rebuilding Mitochondrial Homeostasis and Inhibiting Ferroptosis: Therapeutic Mechanisms and Prospects for Spinal Cord Injury

  • Qin Wang,
  • Qingqing Qin,
  • Wenqiang Liang,
  • Haoran Guo,
  • Yang Diao,
  • Shengsheng Tian and
  • Xin Wang

18 September 2025

During the pathological process of spinal cord injury (SCI), ferroptosis is closely related to mitochondrial homeostasis. Following the occurrence of SCI, the interruption of local blood supply leads to mitochondrial damage within cells and a reducti...

  • Article
  • Open Access
729 Views
29 Pages

17 September 2025

Objective: This study aims to explore the mechanism of regulated cell death-related genes in the development of endometrial carcinoma. Methods: Endometrial carcinoma-related datasets were yielded via the Cancer Genome Atlas and Gene Expression Omnibu...

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Biomedicines - ISSN 2227-9059