Advanced Cancer Diagnosis and Treatment: Third Edition

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 999

Special Issue Editors


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Hirotsu Bio Science Inc., Chiyoda-Ku, Tokyo 102-0094, Japan
Interests: cancer biodiagnostics; early detection of cancers; cancer biomarkers; neurobiology of olfaction; nematode biology
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Special Issue Information

Dear Colleagues,

Cancer is the leading cause of death worldwide. The chances of survival increase with early cancer detection, but around half of all cancers are diagnosed at an advanced stage. Significant endeavors have been made to comprehend cancer's mechanisms, create accurate and sensitive diagnostic options, and produce efficient treatments. Over the past decade, advancements have been made in enhancing cancer screening programs and introducing innovative technologies to improve early cancer detection, with a particular focus on non-invasive methods. Novel approaches in cancer treatment are opening up new avenues for effective therapies.

Acknowledging the significant efforts made in combatting cancer, from academia to the private sector, in this Special Issue, we are seeking original research article or review submissions that present impactful advances in the development of cancer biology, diagnostics, and therapeutics in relation to one or more of, but not limited to, the following topics:

  • Cancer biology;
  • Molecular mechanisms of cancers;
  • Cancer epigenetics;
  • Resistance mechanism to conventional therapies;
  • Cancer biomarkers;
  • Early cancer detection;
  • Clinical investigations;
  • Cancer diagnostics;
  • Novel therapeutics;
  • Novel paradigms in cancer diagnosis and treatment.

Dr. Takaaki Hirotsu
Prof. Dr. Hideshi Ishii
Guest Editors

Manuscript Submission Information

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Keywords

  • cancer biology
  • epigenetics
  • early detection
  • diagnosis
  • biodiagnosis
  • novel therapeutics
  • new paradigms

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Published Papers (2 papers)

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Review

31 pages, 3657 KiB  
Review
Lipid Metabolism Reprogramming in Cancer: Insights into Tumor Cells and Immune Cells Within the Tumor Microenvironment
by Rundong Liu, Chendong Wang, Zhen Tao and Guangyuan Hu
Biomedicines 2025, 13(8), 1895; https://doi.org/10.3390/biomedicines13081895 - 4 Aug 2025
Viewed by 510
Abstract
This review delves into the characteristics of lipid metabolism reprogramming in cancer cells and immune cells within the tumor microenvironment (TME), discussing its role in tumorigenesis and development and analyzing the value of lipid metabolism-related molecules in tumor diagnosis and prognosis. Cancer cells [...] Read more.
This review delves into the characteristics of lipid metabolism reprogramming in cancer cells and immune cells within the tumor microenvironment (TME), discussing its role in tumorigenesis and development and analyzing the value of lipid metabolism-related molecules in tumor diagnosis and prognosis. Cancer cells support their rapid growth through aerobic glycolysis and lipid metabolism reprogramming. Lipid metabolism plays distinct roles in cancer and immune cells, including energy supply, cell proliferation, angiogenesis, immune suppression, and tumor metastasis. This review focused on shared lipid metabolic enzymes and transporters, lipid metabolism-related oncogenes and non-coding RNAs (ncRNAs) involved in cancer cells, and the influence of lipid metabolism on T cells, dendritic cells (DCs), B cells, tumor associated macrophages (TAMs), tumor associated neutrophils (TANs), and natural killer cells (NKs) within TME. Additionally, the role of lipid metabolism in tumor diagnosis and prognosis was explored, and lipid metabolism-based anti-tumor treatment strategies were summarized, aiming to provide new perspectives for achieving precision medicine. Full article
(This article belongs to the Special Issue Advanced Cancer Diagnosis and Treatment: Third Edition)
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Graphical abstract

21 pages, 1962 KiB  
Review
From Survival to Parenthood: The Fertility Journey After Childhood Cancer
by Sofia Rahman, Veronica Sesenna, Diana Osorio Arce, Erika Maugeri and Susanna Esposito
Biomedicines 2025, 13(8), 1859; https://doi.org/10.3390/biomedicines13081859 - 30 Jul 2025
Viewed by 270
Abstract
Background: The advances in cancer diagnosis and treatment have significantly improved survival rates in pediatric patients, with five-year survival now exceeding 80% in many high-income countries. However, these life-saving therapies often carry long-term consequences, including impaired fertility. The reproductive health of childhood [...] Read more.
Background: The advances in cancer diagnosis and treatment have significantly improved survival rates in pediatric patients, with five-year survival now exceeding 80% in many high-income countries. However, these life-saving therapies often carry long-term consequences, including impaired fertility. The reproductive health of childhood cancer survivors has emerged as a key issue in survivorship care. Objective: This narrative review aims to examine the gonadotoxic effects of cancer treatments on pediatric patients, evaluate fertility preservation strategies in both males and females, and provide guidance on the long-term monitoring of reproductive function post treatment. Methods: A comprehensive literature review was conducted using PubMed, including randomized trials, cohort studies, and clinical guidelines published up to March 2024. The keywords focused on pediatric oncology, fertility, and reproductive endocrinology. Studies were selected based on relevance to treatment-related gonadotoxicity, fertility preservation options, and follow-up care. Results: Radiotherapy and alkylating agents pose the highest risk to fertility. Postpubertal patients have access to standardized preservation techniques, while prepubertal options remain experimental. Long-term effects include premature ovarian insufficiency, azoospermia, hypogonadism, and uterine dysfunction. The psychosocial impacts, especially in female survivors, are profound and often overlooked. Conclusions: Fertility preservation should be discussed at diagnosis and integrated into treatment planning in pediatric patients with cancer. While options for postpubertal patients are established, more research is needed to validate safe and effective strategies for younger populations. A multidisciplinary approach and long-term surveillance are essential for safeguarding future reproductive potential in childhood cancer survivors. Full article
(This article belongs to the Special Issue Advanced Cancer Diagnosis and Treatment: Third Edition)
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