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Biomedicines, Volume 13, Issue 9

September 2025 - 275 articles

Cover Story: Iron is indispensable for life yet toxic in excess. Iron utilization is essential to normal physiologic processes across cell types. This paper explores the molecular mechanisms that maintain systemic iron balance and how their disruption leads to multi-organ disease. We outline iron's "lifecycle", key regulatory pathways, and the consequences of their failure, along with iron’s impact on systems including bone marrow, CNS, liver, kidneys, gonads, and endocrine tissues. In each of these, the dangers of overload are described, linking molecular missteps to diverse and potentially chronic syndromes. Finally, emerging therapies such as gene editing and mimetics aimed at restoring iron equilibrium are also discussed. View this paper
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Articles (275)

  • Article
  • Open Access
602 Views
14 Pages

Evaluating Cardio-Protective Molecules by Efficacy Based on Weight Reduction and HbA1c Targets

  • Teodor Salmen,
  • Valeria-Anca Pietrosel,
  • Flaviana-Veronica Urzica,
  • Diana-Elena Visan,
  • Bianca-Margareta Salmen,
  • Radu-Cristian Cimpeanu,
  • Delia Reurean-Pintilei,
  • Mihaela-Simona Popoviciu and
  • Anca Pantea Stoian

20 September 2025

Background: The effectiveness of GLP-1 RAs and SGLT-2i classes, evaluated by a HbA1c target of <7% and body weight reduction (BWR) of 5% in patients with type 2 diabetes mellitus (T2DM), represents the aim of this article. Methods: A retrospective...

  • Review
  • Open Access
1,116 Views
31 Pages

Linking Metabolic Disorders and Immune System Phenomena in Schizophrenia: The Role of Adipose Tissue and Inflammation

  • Aleksandra Julia Oracz,
  • Mateusz Zwierz,
  • Maciej Naumowicz,
  • Stefan Modzelewski,
  • Maria Suprunowicz and
  • Napoleon Waszkiewicz

20 September 2025

Emerging evidence highlights the role of chronic low-grade inflammation and dysregulated cytokines in both obesity and schizophrenia, suggesting overlapping immune system pathways that contribute to cognition and nervous system inflammation. Excess a...

  • Article
  • Open Access
515 Views
18 Pages

20 September 2025

Background: Pediatric sepsis is a life-threatening disease that is associated with the progression of acute lymphoblastic leukemia (ALL) and the recurrence of B-cell ALL (B-ALL). Although previous studies have reported a partial association between s...

  • Article
  • Open Access
488 Views
13 Pages

Bone Mineral Density in HIV-Infected People–the Experience of Craiova Regional Center

  • Florentina Dumitrescu,
  • Livia Dragonu,
  • Eugenia-Andreea Marcu,
  • Vlad Pădureanu,
  • Andreea Cristina Stoian,
  • Cristiana-Luiza Rădoi-Troacă,
  • Rodica Pădureanu,
  • Anca Duduveche,
  • Ilona-Andreea Georgescu and
  • Lucian Giubelan

20 September 2025

Background: Human Immunodeficiency Virus (HIV) is a virus that progressively impairs immune function by depleting CD4 + T-lymphocytes, ultimately leading to acquired immunodeficiency syndrome (AIDS). People living with HIV face a higher risk of devel...

  • Article
  • Open Access
790 Views
14 Pages

20 September 2025

Objectives: This study aimed to compare clinical characteristics, antimicrobial susceptibility, and 28-day mortality between patients with Acinetobacter baumannii bacteremia (ABB) and non-baumannii Acinetobacter bacteremia (NBAB) after rapid matrix-a...

  • Article
  • Open Access
1 Citations
1,061 Views
11 Pages

Thoracic MRI in Pediatric Oncology: Feasibility and Image Quality of Post-Contrast Free-Breathing Radial 3D T1 Weighted Imaging

  • Patricia Tischendorf,
  • Marc-David Künnemann,
  • Tobias Krähling,
  • Jan Hendrik Lange,
  • Walter Heindel and
  • Laura Beck

19 September 2025

Objectives: To compare the feasibility and image quality of a post-contrast free-breathing radial stack-of-stars 3D T1w turbo-field echo Dixon sequence (3D T1w VANE mDIXON) with a conventional cartesian breath-hold 3D T1w fast-field echo mDIXON seque...

  • Article
  • Open Access
1,337 Views
27 Pages

Clinical and dGEMRIC Evaluation of Microfragmented Adipose Tissue Versus Hyaluronic Acid in Inflammatory Phenotype of Knee Osteoarthritis: A Randomized Controlled Trial

  • Vilim Molnar,
  • Željko Jeleč,
  • Eduard Rod,
  • Damir Hudetz,
  • Petar Brlek,
  • Igor Borić,
  • Vid Matišić,
  • Jana Mešić,
  • Eduard Stjepan Pavelić and
  • Dinko Vidović
  • + 11 authors

19 September 2025

Background: Knee osteoarthritis (OA) is a leading cause of disability, with limited therapies that modify both symptoms and structural degeneration. Autologous microfragmented adipose tissue (MFAT) has emerged as a promising regenerative option, espe...

  • Review
  • Open Access
822 Views
16 Pages

A Potential Role of Adropin in Inflammatory Rheumatic Diseases—What Do We Know So Far?

  • Petra Simac,
  • Marin Petric,
  • Marijana Jankovic Danolic and
  • Dijana Perković

19 September 2025

Adropin is a regulatory peptide hormone involved in metabolic homeostasis, cardiovascular protection, and immune modulation. Recent evidence suggests that adropin plays a role in the pathophysiology of autoimmune rheumatic diseases (ARDs) by influenc...

  • Review
  • Open Access
2,395 Views
28 Pages

19 September 2025

Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality. A central driver in its pathogenesis is alveolar epithelial cell (AEC) dysfunction, which leads to disruption of the epithelial barrier, impaired fluid cl...

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Biomedicines - ISSN 2227-9059