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Biomedicines, Volume 12, Issue 8

August 2024 - 306 articles

Cover Story: Traumatic Brain Injury (TBI) is a leading cause of death and disability as there are currently no FDA-approved treatments, thus resulting in inflammation, tissue atrophy, and neurological deficits in patients. Schantz, Sneed et al. demonstrated that induced pluripotent stem cell (iPSC)-derived neural stem cells (NSCs) are a promising therapeutic that promoted recovery through immunomodulation, tissue regeneration, and tissue preservation in a translational piglet TBI model with comparable neuroanatomy and physiology to pediatric TBI patients. These cellular-level outcomes led to enhanced functional recovery and increased survivability in piglets, thus supporting further investigations to advance NSC treatment from the bench to bedside. View this paper
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Articles (306)

  • Article
  • Open Access
4 Citations
2,179 Views
17 Pages

Effects of Resistant-Starch-Encapsulated Probiotic Cocktail on Intestines Damaged by 5-Fluorouracil

  • Jui-Ling Wang,
  • Chin-Hsing Yeh,
  • Shih-Hung Huang,
  • Lawrence Shih-Hsin Wu and
  • Miles Chih-Ming Chen

Probiotics and prebiotics have gained attention for their potential health benefits. However, their efficacy hinges on probiotic survival through the harsh gastrointestinal environment. Microencapsulation techniques provide a solution, with resistant...

  • Review
  • Open Access
5 Citations
6,849 Views
17 Pages

Postural Orthostatic Tachycardia Syndrome (POTS) affects up to 1% of the US population, predominantly women, and is characterized by a complex, elusive etiology and heterogeneous phenotypes. This review delves into the intricate physiology and etiolo...

  • Article
  • Open Access
4 Citations
2,208 Views
11 Pages

Clinical Evaluation of Adrenal Incidentaloma: The Experience of a Referral Center

  • Luigi Petramala,
  • Francesco Circosta,
  • Luca Marino,
  • Edoardo Palombi,
  • Maria Ludovica Costanzo,
  • Adriana Servello,
  • Gioacchino Galardo and
  • Claudio Letizia

The number of adrenal incidentaloma (AI) cases has increased in the last few years due to the widespread use of imaging diagnostics. Management requires evaluation of the malignant nature and hormonal activity. The aim of the present study is to asse...

  • Article
  • Open Access
8 Citations
2,800 Views
15 Pages

Lymphocytic Myocarditis in Children with Parvovirus B19 Infection: Pathological and Molecular Insights

  • Lisann Pelzl,
  • Sabrina Mantino,
  • Martina Sauter,
  • Tatiana Manuylova,
  • Ulrich Vogel and
  • Karin Klingel

Background: This study aims to evaluate the role of parvovirus B19 (B19V) in the pathogenesis of myocarditis in a paediatric population, including post-mortem samples from two children. Methods: From 2004 to 2023, endomyocardial biopsies (EMBs) from...

  • Article
  • Open Access
1 Citations
2,212 Views
20 Pages

The Sigma-1 Receptor Exacerbates Cardiac Dysfunction Induced by Obstructive Nephropathy: A Role for Sexual Dimorphism

  • Francisco Javier Munguia-Galaviz,
  • Alejandra Guillermina Miranda-Diaz,
  • Yanet Karina Gutierrez-Mercado,
  • Marco Ku-Centurion,
  • Ricardo Arturo Gonzalez-Gonzalez,
  • Eliseo Portilla-de Buen and
  • Raquel Echavarria

The Sigma-1 Receptor (Sigmar1) is a stress-activated chaperone and a promising target for pharmacological modulation due to its ability to induce multiple cellular responses. Yet, it is unknown how Sigmar1 is involved in cardiorenal syndrome type 4 (...

  • Article
  • Open Access
9 Citations
2,819 Views
15 Pages

Background: Accumulating evidence has suggested the pathogenic roles of chronic inflammation and neutrophils in diabetic kidney disease (DKD). This study investigated the relationship between neutrophils, all-cause, and cardiovascular disease (CVD) m...

  • Article
  • Open Access
3 Citations
2,068 Views
18 Pages

The vast majority of gastric cancer (GC) cases are adenocarcinomas including intestinal and diffuse GC. The incidence of diffuse GC, often associated with poor overall survival, has constantly increased in Western countries. Epidemiological studies h...

  • Review
  • Open Access
7 Citations
3,646 Views
33 Pages

Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

  • Shaza Issa,
  • Haidar Fayoud,
  • Alisa Shaimardanova,
  • Albert Sufianov,
  • Galina Sufianova,
  • Valeriya Solovyeva and
  • Albert Rizvanov

Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities o...

  • Article
  • Open Access
2 Citations
2,227 Views
16 Pages

BP1003 Decreases STAT3 Expression and Its Pro-Tumorigenic Functions in Solid Tumors and the Tumor Microenvironment

  • Maria Gagliardi,
  • Rhonda Kean,
  • Bingbing Dai,
  • Jithesh Jose Augustine,
  • Michael Roberts,
  • Jason Fleming,
  • D. Craig Hooper and
  • Ana Tari Ashizawa

Overexpression and aberrant activation of signal transducer and activator of transcription 3 (STAT3) contribute to tumorigenesis, drug resistance, and tumor-immune evasion, making it a potential cancer therapeutic target. BP1003 is a neutral liposome...

  • Article
  • Open Access
1 Citations
2,325 Views
12 Pages

Diabetes and Its Impact on Cardiogenic Shock Outcomes in Acute Myocardial Infarction with Polyvascular Disease: A Comparative Analysis

  • Marlon V. Gatuz,
  • Rami Abu-Fanne,
  • Dmitry Abramov,
  • Mamas A. Mamas,
  • Ariel Roguin and
  • Ofer Kobo

Background: Diabetes mellitus (DM) significantly impacts cardiovascular outcomes, particularly in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS). The presence of polyvascular disease further complicates the prog...

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Biomedicines - ISSN 2227-9059