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Biomedicines, Volume 10, Issue 11

November 2022 - 329 articles

Cover Story: Specialized pro-resolving molecules (SPMs) are endogenous mediators destined to resolve inflammation. Each sub-class, resolvins, maresins, lipoxins, and protectins, has a complex temporal and functional interdependence with the rest, which brings about the resolution of inflammation through various pathways. These include the following: (1) increasing the effectiveness of efferocytosis, a process of clearing apoptotic cells; (2) reducing the levels of pro-inflammatory molecules such as MCP-1, VCAM-1, and leukotriene B4, which recruit inflammatory cells to the plaque site, increasing its size and instability. By restricting inflammation, SPMs reduce plaque size and increase its stability, leading to the prevention of life-threatening events in cardiovascular disease. View this paper
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Articles (329)

  • Article
  • Open Access
17 Citations
4,300 Views
21 Pages

21 November 2022

The role of gut microbes has been suggested in type 2 diabetes (T2DM) risk. However, their results remain controversial. We hypothesized that Asians with T2DM had different fecal bacterial compositions, co-abundance networks, and metagenome functions...

  • Article
  • Open Access
8 Citations
3,457 Views
16 Pages

PET/CT with 18F-choline or 18F-FDG in Hepatocellular Carcinoma Submitted to 90Y-TARE: A Real-World Study

  • Luca Filippi,
  • Oreste Bagni,
  • Ermanno Notarianni,
  • Adelchi Saltarelli,
  • Cesare Ambrogi and
  • Orazio Schillaci

21 November 2022

Our aim was to assess the role of positron emission computed tomography (PET/CT) with 18F-choline (18F-FCH) or 18F-fluorodeoxyglucose (18F-FDG) in hepatocellular carcinoma (HCC) submitted to 90Y-radioembolization (90Y-TARE). We retrospectively analyz...

  • Review
  • Open Access
21 Citations
12,810 Views
25 Pages

Three-Dimensional Constructive Interference in Steady State (3D CISS) Imaging and Clinical Applications in Brain Pathology

  • Marco Cavallaro,
  • Alessandra Coglitore,
  • Agostino Tessitore,
  • Karol Galletta,
  • Luciano Frosina,
  • Antonino Cuffari,
  • Roberta Ingrassia,
  • Sarah Caroline Scarcella,
  • Michele Caponnetto and
  • Mirta Longo
  • + 3 authors

21 November 2022

Three-dimensional constructive interference in steady state (3D CISS) is a steady-state gradient-echo sequence in magnetic resonance imaging (MRI) that has been used in an increasing number of applications in the study of brain disease in recent year...

  • Article
  • Open Access
3 Citations
2,623 Views
13 Pages

21 November 2022

Challenges posed by the retention of radiopharmaceuticals in unintended organs affect the quality of patient procedures when undergoing diagnostics and therapeutics. The aim of this study was to formulate a suitable tracer encapsulated in liposomes u...

  • Article
  • Open Access
8 Citations
4,055 Views
15 Pages

21 November 2022

Molecular mechanisms underlying breast cancer (BC) progression are complex and remain unclear. In this study, we used bioinformatic tools to identify genes associated with tumor progression mechanisms and novel therapeutic targets in BC. We identifie...

  • Article
  • Open Access
15 Citations
5,070 Views
16 Pages

21 November 2022

Dienogest (DNG) is a therapeutic medication used in endometriosis treatment. Limited data are available regarding its mechanism of action on endometrial cells. Using in vivo and in vitro models, we investigated whether DNG treatment causes significan...

  • Article
  • Open Access
6 Citations
3,477 Views
18 Pages

Effect of Renal Ischemia Reperfusion on Brain Neuroinflammation

  • Bina Lee,
  • Ingabire Ines,
  • Jihyun Je,
  • Eun Jung Park,
  • Hyemin Seong,
  • Min Gi Jo,
  • Hwajin Kim,
  • Seon-Hee Kim,
  • Seong Jae Kim and
  • Hye Jung Kim
  • + 3 authors

21 November 2022

Acute kidney injury (AKI) is an inflammatory sequence. It can lead to distant organ injury, including damage to the central nervous system (CNS), mediated by increased circulating cytokines and other inflammatory mediators. It can also lead to increa...

  • Article
  • Open Access
29 Citations
4,660 Views
14 Pages

Anti-Inflammatory Activity of Olive Oil Polyphenols—The Role of Oleacein and Its Metabolites

  • Vânia Costa,
  • Marlene Costa,
  • Romeu António Videira,
  • Paula Branquinho Andrade and
  • Fátima Paiva-Martins

21 November 2022

The anti-inflammatory potential of oleacein, the main polyphenolic compound found in olive oil, and its main metabolites were characterized by their effects on RAW 264.7 macrophages challenged with lipopolysaccharide (LPS), and by their ability to in...

  • Article
  • Open Access
5 Citations
2,593 Views
16 Pages

21 November 2022

Pancreatic volume and fat fraction are critical prognoses for metabolic diseases like type 2 diabetes (T2D). Magnetic Resonance Imaging (MRI) is a required non-invasive quantification method for the pancreatic fat fraction. The dramatic development o...

  • Article
  • Open Access
5 Citations
2,781 Views
13 Pages

Adjuvant Chemoradiotherapy Associated with Improved Overall Survival in Resected Esophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy in Intensity-Modulated Radiotherapy Era

  • Wing-Keen Yap,
  • Ming-Chieh Shih,
  • Yu-Chen Chang,
  • Chia-Hsin Lin,
  • Shih-Ming Huang,
  • Tsung-You Tsai,
  • Ching-Fu Chang,
  • Chih-Chung Hsu,
  • Chen-Kan Tseng and
  • Miao-Fen Chen
  • + 6 authors

21 November 2022

Background: The prognosis of patients with resected esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy is particularly poor in those who were staged as ypT3/T4 and/or ypN+. This study investigated whether adjuvant chemoradiotherap...

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Biomedicines - ISSN 2227-9059