Special Issue "Animal Models for Study of Pathophysiological Mechanisms of Hypertension and Its Complications"
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Molecular and Translational Medicine".
Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 16300
Special Issue Editors
Interests: hemodynamics; vascular sensitivity and reactivity; cell calcium handling; ion transport
Interests: renin-angiotensin system; endothelin system; gliflozins; chronic kidney disease
Special Issue Information
Dear Colleagues,
Since essential hypertension is part of many important health care problems, it is necessary to investigate its mechanisms in animal models. This type of experimental research may have potential clinical importance. This Special Issue will be focused on several important topics, including:
1) The pathophysiological mechanisms responsible for:
i) Blood pressure elevation during hypertension development and maintenance;
ii) Organ damage in chronic hypertension;
iii) Drug targeting of hypertension and its complications.
2) The participation of:
i) Central and peripheral blood pressure control;
ii) Vascular hypertrophy and endothelial damage;
iii) Neural, humoral, and endocrine factors;
iv) Immune mechanisms.
3) The role of:
i) Altered redox signaling;
ii) Chronic inflammation;
iii) Microbiome changes;
iv) Genetic and/or environmental factors.
4) The progress in:
i) Pharmacological tools for the control of hypertension and organ damage;
ii) Genetic modifications to alter blood pressure level;
iii) Non-pharmacological interventions attenuating hypertension and its complications.
Original articles or reviews might also cover a) interesting aspects of particular research fields in the pathophysiology of hypertension and that are associated end-organ damage, b) the use of various experimental hypertensive models, and c) the importance of specific environmental factors acting in different phases of the ontogeny of hypertension. The presentation of new ideas as well as the critical discussion of traditional theories is also welcome.
Dr. Josef Zicha
Dr. Ivana Vaněčková
Guest Editors
Manuscript Submission Information
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Keywords
- genetic hypertension
- salt hypertension
- nutrition
- antihypertensive therapy
- renin-angiotensin-aldosterone system
- sympathetic tone
- nitric oxide
- vascular resistance
- oxidative stress
- kidney damage