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Volume 12
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10.3390/plants12162936
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Article

Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger (Zingiber officinale) Extract in Iron-Loaded Huh7 Cells

by
Hataichanok Chuljerm
1,2,
Narisara Paradee
3,
Dabudsawin Katekaew
4,
Panaphat Nantachai
4,
Kornvipa Settakorn
3,
Somdet Srichairatanakool
3 and
Pimpisid Koonyosying
3,*
1
School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand
2
Environmental-Occupational Health Sciences and Non Communicable Diseases Research Center, Research Institute for Health Sciences Chiang Mai University, Chiang Mai 50200, Thailand
3
Department of Biochemistry, Faculty of Medicine Chiang Mai University, Chiang Mai 50200, Thailand
4
Science Classroom Affiliated School Project, Chiang Mai University Demonstration School, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Plants 2023, 12(16), 2936; https://doi.org/10.3390/plants12162936
Submission received: 8 July 2023 / Revised: 9 August 2023 / Accepted: 10 August 2023 / Published: 14 August 2023
(This article belongs to the Special Issue Structural and Functional Analysis of Extracts in Plants IV)
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Abstract

Iron is essential for numerous biological processes; however, an iron imbalance can contribute to a number of diseases. An excess of iron can accumulate in the body and subsequently induce the production of reactive oxygen species (ROS), leading to oxidative tissue damage and organ dysfunction. The liver, a major iron storage site, is vulnerable to this iron-induced oxidative damage; however, this issue can be overcome by the chelation of excess iron. This study aimed to investigate the effect of 6-gingerol-rich ginger (Zingiber officinale) extract on iron chelation, antioxidation, and hepatoprotective function in protecting against iron-induced oxidative liver cell injury. In experiments, 6-gingerol was confirmed to be a main bioactive component of the ginger extract and possessed free radical scavenging activity, decreasing ABTS•+ and DPPH• radical levels, and inhibiting AAPH-induced red blood cell hemolysis. Interestingly, the extract significantly reduced the levels of labile cellular iron (LCI), intracellular ROS, and lipid peroxidation products (TBARS) in iron-loaded human hepatoma (Huh7) cells. In conclusion, this work highlights the iron chelation property of 6-gingerol-rich ginger extract and its antioxidant activity, which could potentially protect the liver from iron-induced oxidative tissue damage.
Keywords: ginger extract; 6-gingerol; hepatoprotective; iron ginger extract; 6-gingerol; hepatoprotective; iron
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MDPI and ACS Style

Chuljerm, H.; Paradee, N.; Katekaew, D.; Nantachai, P.; Settakorn, K.; Srichairatanakool, S.; Koonyosying, P. Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger (Zingiber officinale) Extract in Iron-Loaded Huh7 Cells. Plants 2023, 12, 2936. https://doi.org/10.3390/plants12162936

AMA Style

Chuljerm H, Paradee N, Katekaew D, Nantachai P, Settakorn K, Srichairatanakool S, Koonyosying P. Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger (Zingiber officinale) Extract in Iron-Loaded Huh7 Cells. Plants. 2023; 12(16):2936. https://doi.org/10.3390/plants12162936

Chicago/Turabian Style

Chuljerm, Hataichanok, Narisara Paradee, Dabudsawin Katekaew, Panaphat Nantachai, Kornvipa Settakorn, Somdet Srichairatanakool, and Pimpisid Koonyosying. 2023. "Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger (Zingiber officinale) Extract in Iron-Loaded Huh7 Cells" Plants 12, no. 16: 2936. https://doi.org/10.3390/plants12162936

APA Style

Chuljerm, H., Paradee, N., Katekaew, D., Nantachai, P., Settakorn, K., Srichairatanakool, S., & Koonyosying, P. (2023). Iron Chelation Property, Antioxidant Activity, and Hepatoprotective Effect of 6-Gingerol-Rich Ginger (Zingiber officinale) Extract in Iron-Loaded Huh7 Cells. Plants, 12(16), 2936. https://doi.org/10.3390/plants12162936

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