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Biomolecules, Volume 9, Issue 2
February 2019 - 44 articles
Cover Story: In eukaryotic cells, liquid–liquid phase separation of ribonucleoproteins (RNPs) drives regulated segregation of its macromolecules in space and time. The physiochemical microenvironment of the phase separated RNP condensates, sensitively depend on protein–protein interactions, which can be tuned by the linear sequence of the RNP chain. Here, we show that sequence-independent entropic forces that emerge within the crowded cellular space, facilitate RNP condensation. With increasing crowding, the RNP–RNP homotypic attraction is enhanced. This drives maturation of RNP condensates from a viscous fluid to a viscoelastic gel-like state. Our findings shed light on a key role of molecular crowding in tuning the phase behavior and mesoscale dynamics of membrane-less organelles. View this paper.
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Biomolecules - ISSN 2218-273X