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Biomolecules, Volume 14, Issue 4
April 2024 - 125 articles
Cover Story: The administration of dietary Corinthian currant in a mouse model of Alzheimer’s disease using 5xFAD increases the activity of the antioxidant enzyme Paraoxonase-1 (PON1) and reduces oxidative stress in circulation and the brain during the early stages of the disease. However, during the later stages of the disease, no beneficial effects are observed. The increased activity of PON1 in plasma can be attributed to the capacity of Corinthian currant phenolics to increase PON1 expression in hepatocytes, the major source of this enzyme in organisms. Given that oxidative stress starts early in the progression of Alzheimer’s disease, the current findings suggest that any intervention with Corinthian currants should commence in the early stages of disease pathogenesis before the onset of significant neurodegeneration. View this paper
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Biomolecules - ISSN 2218-273X