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Biomolecules, Volume 14, Issue 12
December 2024 - 174 articles
Cover Story: Antimicrobial resistance (AMR) and cancer are pressing global health threats. Advances in medicinal chemistry have led to the development of hybrid compounds targeting both AMR and cancer. A recent study reported that a series of 4-substituted-5-(2-(pyridine-2-ylamino)ethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones and their chloro analogs possess antimicrobial and anticancer activities. Two 1,2,4-triazole-3-thiones were identified as exceptionally active (MIC 0.9 µg/mL) against C. tenuis, while several chloropyridine derivatives had high antibacterial potency. The target compounds, especially two pyridine ring-bearing hydrazone, significantly reduced cancer cell viability; in silico modeling indicated that they target the MAP kinase pathway, and 4-methylthiobenzylidene derivative demonstrated the highest affinity. View this paper
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Biomolecules - ISSN 2218-273XCreative Common CC BY license