New Advances of Cannabinoid Receptors in Health and Disease: 2nd Edition

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (15 February 2025) | Viewed by 6506

Special Issue Editor


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Guest Editor
1. Department of Psychiatry, New York University Langone Medical Center, New York City, NY, USA
2. Scientist, Faculty at Columbia University Medical Center, Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, NY, USA
Interests: endocannabinoids; synaptic plasticity; FASD; AUD; neurodegeneration; learning and memory; epigenetics; gene expression; behavior
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Special Issue Information

Dear Colleagues,

Following a very successful first run, we are pleased to announce the launch of a second edition of a Special Issue on Advances in Cannabinoid Receptors in Health and Disease.

Over the last 30 years, the endocannabinoid system (including cannabinoid receptors) has become an imperative neuromodulatory system, having been shown to play an essential role in health and diseases. Cannabinoid receptors have been implicated in multiple pathophysiological events, ranging from addiction, alcohol abuse and neurodegeneration to memory-related disorders. Significant knowledge has been acquired over the last 25 years. However, much more research is still indispensable to fully appreciate the complex functions of cannabinoid receptors, particularly in vivo, and to unravel their true potential as a source of therapeutic targets.

This Special Issue of Biomolecules aims to present a collection of studies focusing on the most recent advancements in cannabinoid receptor structure, signaling and function in health and disease, including developmental and adult-associated research. Authors are invited to submit cutting-edge reviews, original research articles and meta-analyses of large existing datasets, advancing the field toward a greater understanding of its fundamental and pathophysiological mechanisms. Publication topics include, but are not limited to, studies concerning epidemiology, cancer biology, neuropsychology, neurobehavior, neuropharmacology, epigenetics, genetics and genomics, brain imaging, molecular neurobiology, experimental models and clinical investigations in the format of full-length reviews or original articles. However, other formats reduced in length could also be considered, such as brief reports, short notes, communications or commentaries, as long as the manuscript presents innovative and perceptive content that competently suits the topic of this Special Issue.

Dr. Balapal S. Basavarajappa
Guest Editor

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Keywords

  • neurodegeneration
  • alcohol
  • addiction
  • signaling
  • structure–function

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Related Special Issue

Published Papers (3 papers)

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Research

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12 pages, 1019 KiB  
Article
Identification of a Possible Endocannabinoid-Mediated Mechanism of Action of Cetylated Fatty Acids
by Giulia Bononi, Carlotta Granchi, Tiziano Tuccinardi and Filippo Minutolo
Biomolecules 2025, 15(3), 363; https://doi.org/10.3390/biom15030363 - 2 Mar 2025
Viewed by 898
Abstract
Some musculoskeletal disorders, including osteoarthritis; arthrosis; post-traumatic injuries; and other inflammatory tendon, joint and muscular afflictions, still represent unmet medical needs. Cetylated fatty acids (CFAs) are key components of widely distributed over-the-counter products, especially for topical use, which are intended to reduce symptoms [...] Read more.
Some musculoskeletal disorders, including osteoarthritis; arthrosis; post-traumatic injuries; and other inflammatory tendon, joint and muscular afflictions, still represent unmet medical needs. Cetylated fatty acids (CFAs) are key components of widely distributed over-the-counter products, especially for topical use, which are intended to reduce symptoms associated with these conditions. Nevertheless, the mechanism of action of CFAs’ analgesic and anti-inflammatory properties has not yet been clearly established. Endocannabinoids, such as 2-arachidonoylglycerol (2-AG) and anandamide (AEA), are known to produce analgesic and anti-inflammatory effects. These compounds undergo physiological inactivation operated by several enzymes, including monoacylglycerol lipase (MAGL). We herein demonstrate for the first time that the therapeutic effects of CFAs may be attributable, at least in part, to their MAGL inhibition activities, which induce a local increase in analgesic/anti-inflammatory endocannabinoids in close proximity to the site of administration. These findings pave the way for the development of new potent local analgesic agents, whose action is based on an indirect cannabinoid effect. Full article
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Review

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22 pages, 2166 KiB  
Review
Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol
by Roberto Bonanni, Patrizia Ratano, Ida Cariati, Virginia Tancredi and Pierangelo Cifelli
Biomolecules 2024, 14(12), 1627; https://doi.org/10.3390/biom14121627 - 19 Dec 2024
Cited by 1 | Viewed by 2009
Abstract
Painful conditions of the pelvic floor include a set of disorders of the pelvic region, discreetly prevalent in the female population, in which pain emerges as the predominant symptom. Such disorders have a significant impact on quality of life as they impair couple [...] Read more.
Painful conditions of the pelvic floor include a set of disorders of the pelvic region, discreetly prevalent in the female population, in which pain emerges as the predominant symptom. Such disorders have a significant impact on quality of life as they impair couple relationships and promote states of anxiety and irascibility in affected individuals. Although numerous treatment approaches have been proposed for the management of such disorders, there is a need to identify strategies to promote muscle relaxation, counter pelvic pain, and reduce inflammation. The endocannabinoid system (ECS) represents a complex system spread throughout the body and is involved in the regulation of numerous physiological processes representing a potential therapeutic target for mood and anxiety disorders as well as pain management. Cannabidiol (CBD), acting on the ECS, can promote relief from hyperalgesia and allodynia typical of disorders affecting the pelvic floor and promote muscle relaxation by restoring balance to this delicate anatomical region. However, its use is currently limited due to a lack of evidence supporting its efficacy and harmlessness, and the mechanism of action on the ECS remains partially unexplored to this day. This comprehensive review of the literature examines the impact of pain disorders affecting the pelvic floor and major treatment approaches and brings together the main evidence supporting CBD in the management of such disorders. Full article
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30 pages, 1618 KiB  
Review
Unveiling the Potential of Phytocannabinoids: Exploring Marijuana’s Lesser-Known Constituents for Neurological Disorders
by Balapal S. Basavarajappa and Shivakumar Subbanna
Biomolecules 2024, 14(10), 1296; https://doi.org/10.3390/biom14101296 - 13 Oct 2024
Cited by 2 | Viewed by 2980
Abstract
Cannabis sativa is known for producing over 120 distinct phytocannabinoids, with Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) being the most prominent, primarily in their acidic forms. Beyond Δ9-THC and CBD, a wide array of lesser-known phytocannabinoids, along with [...] Read more.
Cannabis sativa is known for producing over 120 distinct phytocannabinoids, with Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) being the most prominent, primarily in their acidic forms. Beyond Δ9-THC and CBD, a wide array of lesser-known phytocannabinoids, along with terpenes, flavonoids, and alkaloids, demonstrate diverse pharmacological activities, interacting with the endocannabinoid system (eCB) and other biological pathways. These compounds, characterized by phenolic structures and hydroxyl groups, possess lipophilic properties, allowing them to cross the blood–brain barrier (BBB) effectively. Notably, their antioxidant, anti-inflammatory, and neuro-modulatory effects position them as promising agents in treating neurodegenerative disorders. While research has extensively examined the neuropsychiatric and neuroprotective effects of Δ9-THC, other minor phytocannabinoids remain underexplored. Due to the well-established neuroprotective potential of CBD, there is growing interest in the therapeutic benefits of non-psychotropic minor phytocannabinoids (NMPs) in brain disorders. This review highlights the emerging research on these lesser-known compounds and their neuroprotective potential. It offers insights into their therapeutic applications across various major neurological conditions. Full article
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