Emerging Biomarkers Discovery for Molecular Diagnostics

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 728

Special Issue Editors

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Guest Editor
Laboratory of Pediatrics, School of Pharmacy, Aichi-Gakuin University, 1-100 Kusumoto, Chikusa, Nagoya 464-8650, Japan
Interests: pediatrics; Kawasaki disease; pentraxin 3; soluble pattern-recognition molecule; cytokines; enzyme preparations; cell death; sensitivity prediction; amino acid requirement; selective toxicity; pediatric hematology/oncology; amino acid metabolism; anticancer drugs; pediatric leukemia; flow cytometry; immunohistochemistry; monoclonal antibodies; asparagine synthetase; l-asparaginase; selective toxicity to cancer cells

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Guest Editor
Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University Hospital, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
Interests: pediatric rheumatology; autoinflammatory disease; cytokine; pediatric rheumatology; cytokinesis; Kawasaki disease; macrophage activation syndrome; juvenile idiopathic arthritis; systemic lupus erythematosus

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Guest Editor
Department of Allergology, Rheumatology and Clinical Immunology, University Medical Centre Ljubljana, Bohoriceva 20, Sl-1525 Ljubljana, Slovenia
Interests: autoinflammatory diseases; systemic lupus erythematosus; antiphospholipid syndrome; pediatric rheumatology; autoimmunity; rheumatology
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Special Issue Information

Dear Colleagues,

Biomarkers play a crucial role in the early detection, diagnosis, and treatment of diseases. With ongoing research and technological advancements, new biomarkers continue to be discovered and applied in practical settings. In recent years, the related field has experienced explosive growth, generating significant interest in this expanding field of personalized medicine. This Special Issue aims to explore the latest research findings and innovative approaches in this field to drive advancements in molecular diagnostics and facilitate the realization of personalized medicine.

We welcome submissions focusing on the mechanisms and applications of various types of biomarkers, including, but not limited to, genes, proteins, metabolites, and extracellular vesicles. We encourage contributions related to biomarker research in different diseases, such as cancer, cardiovascular diseases, neurological disorders, etc.

This Special Issue will cover, but is not limited to, the following topics:

  • Emerging biomarker discovery and identification;
  • Biomarkers in early disease detection and screening;
  • Biomarkers in disease diagnosis and classification;
  • Biomarkers for monitoring and prognosis evaluation;
  • The potential of biomarkers in personalized medicine;
  • Biomarkers in drug development and clinical trials;
  • The association between biomarkers and disease mechanisms;
  • The relationship between biomarkers and genetic variations;
  • Biomarkers in translational medicine;
  • Bioinformatics analysis and data mining of biomarkers.

We encourage researchers in this field to submit their research work, sharing their latest findings and innovative methods. This Special Issue is dedicated to advancing the field of molecular diagnostics and the realization of personalized medicine.

Please note that, as a journal of molecular science, clinical research is not the primary focus of Biomolecules. Studies involving molecular and cellular experiments, as well as preclinical research related to the aforementioned topics, are welcome.

Prof. Dr. Toshiyuki Kitoh
Dr. Masaki Shimizu
Prof. Dr. Tadej Avĉin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • emerging biomarkers
  • pre-clinical
  • molecular diagnostics
  • deep sequencing
  • omics
  • personalized medicine
  • precision medicine
  • targeted therapy
  • prognosis

Published Papers (1 paper)

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11 pages, 591 KiB  
Serum Neuron-Specific Enolase as a Biomarker of Neonatal Brain Injury—New Perspectives for the Identification of Preterm Neonates at High Risk for Severe Intraventricular Hemorrhage
by Dimitra Metallinou, Grigorios Karampas, Maria-Loukia Pavlou, Maria-Ioanna Louma, Aimilia Mantzou, Antigoni Sarantaki, Christina Nanou, Kleanthi Gourounti, Maria Tzeli, Nikoletta Pantelaki, Evangelos Tzamakos, Theodora Boutsikou, Aikaterini Lykeridou and Nicoletta Iacovidou
Biomolecules 2024, 14(4), 434; https://doi.org/10.3390/biom14040434 - 03 Apr 2024
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Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case–control study aimed at investigating the levels and prognostic value of serum neuron-specific enolase (NSE) during the first 3 days of life in [...] Read more.
Neonatal brain injury (NBI) is a critical condition for preterm neonates with potential long-term adverse neurodevelopmental outcomes. This prospective longitudinal case–control study aimed at investigating the levels and prognostic value of serum neuron-specific enolase (NSE) during the first 3 days of life in preterm neonates (<34 weeks) that later developed brain injury in the form of either periventricular leukomalacia (PVL) or intraventricular hemorrhage (IVH) during their hospitalization. Participants were recruited from one neonatal intensive care unit, and on the basis of birth weight and gestational age, we matched each case (n = 29) with a neonate who had a normal head ultrasound scan (n = 29). We report that serum NSE levels during the first three days of life do not differ significantly between control and preterm neonates with NBI. Nevertheless, subgroup analysis revealed that neonates with IVH had significantly higher concentrations of serum NSE in comparison to controls and neonates with PVL on the third day of life (p = 0.014 and p = 0.033, respectively). The same pattern on the levels of NSE on the third day of life was also observed between (a) neonates with IVH and all other neonates (PVL and control; p = 0.003), (b) neonates with II–IV degree IVH and all other neonates (p = 0.003), and (c) between control and the five (n = 5) neonates that died from the case group (p = 0.023). We conclude that NSE could be an effective and useful biomarker on the third day of life for the identification of preterm neonates at high risk of developing severe forms of IVH. Full article
(This article belongs to the Special Issue Emerging Biomarkers Discovery for Molecular Diagnostics)
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