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Biomolecules, Volume 11, Issue 7
July 2021 - 146 articles
Cover Story: Rett syndrome (RTT) is a devastating neurodevelopmental disease—the pathogenetic mechanisms of which are still under investigation.
RTT is caused by mutations in MeCP2, a master epigenetic modulator of transcription, involved in the organization of chromatin architecture. MeCP2 dysfunction leads to large‐scale alterations of the epigenome, including increased oxidation of mC, abnormal binding of chromatin-associated proteins, unbalanced deposition of epigenetic modifications, deregulated gene expression and altered acetylation of histone and transcription factors. Further examination of the epigenomic and transcriptomic alterations caused by MeCP2 dysfunction may help to develop focused therapeutic strategies for RTT. View this paper
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Biomolecules - ISSN 2218-273X