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Biomolecules, Volume 11, Issue 6
June 2021 - 149 articles
Cover Story: The ability to cope with deuterium, a stable isotope of hydrogen, decreases with the complexity of the organism. In vivo reaction to high deuterium concentration is complex and includes disruption of the cell cycle. Chlamydomonas reinhardtii, a microalga dividing by multiple fission, is a powerful model to study deuterium effects on cell cycle progression. In the current study, we present how deuterium affects growth and cell cycle progression in C. reinhardtii. We infer concentration-dependent decrease in growth rates accompanied by accumulation of energy reserves. Furthermore, deuterium prolongs the duration of the cell cycle in Chlamydomonas, changes the pattern of kinase activity prior to cell division, and delays commitment point attainment as proven by the novel approach deployed in this study. View this paper
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Biomolecules - ISSN 2218-273X