Next Article in Journal
Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors
Next Article in Special Issue
Alpha-Amylase and Alpha-Glucosidase Enzyme Inhibition and Antioxidant Potential of 3-Oxolupenal and Katononic Acid Isolated from Nuxia oppositifolia
Previous Article in Journal
Fatty Acids of Marine Mollusks: Impact of Diet, Bacterial Symbiosis and Biosynthetic Potential
Previous Article in Special Issue
A Novel Kunitzin-Like Trypsin Inhibitor Isolated from Defensive Skin Secretion of Odorrana versabilis
Open AccessArticle

Glucose Uptake Stimulatory and PTP1B Inhibitory Activities of Pimarane Diterpenes from Orthosiphon stamineus Benth

1
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 122100, Vietnam
2
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 122100, Vietnam
3
Faculty of Pharmacy, Dong A University, 33 Xo Viet Nghe Tinh, Hai Chau District, Da Nang 550000, Vietnam
4
Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi 123106, Vietnam
5
Biomedical Sciences Department, Institute for Research & Executive Education (VNUK), The University of Danang, 158A Le Loi, Hai Chau, Danang 551000, Vietnam
6
Faculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong, Hanoi 12116, Vietnam
7
Phenikaa Research and Technology Institute (PRATI), A&A Green Phoenix Group JSC, No.167 Hoang Ngan, Trung Hoa, Cau Giay, Hanoi 11313, Vietnam
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2019, 9(12), 859; https://doi.org/10.3390/biom9120859
Received: 24 October 2019 / Revised: 9 December 2019 / Accepted: 9 December 2019 / Published: 11 December 2019
Seven pimarane diterpenes (17) were isolated from Orthosiphon stamineus Benth. by assay-guided isolation. All of the isolates possessed a 2-deoxy-2-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)-d-glucose uptake effect in 3T3-L1 adipocytes at concentrations of 5 and 10 μM. Most of them showed potent inhibition against protein tyrosine phosphatase 1B with IC50 values ranging from 0.33 to 9.84 μM. In the kinetic study, all inhibition types were exposed for the examined potencies, including mixed-competitive (1), non-competitives (3 and 5), competitive (6), and uncompetitive (7). The results suggested that O. stamineus and its pimarane diterpenes might exert the hypoglycemic effect via the insulin signaling pathway targeting inhibition of protein tyrosine phosphatase 1B (PTP1B) activity. View Full-Text
Keywords: Lamiaceae; Orthosiphon stamineus; Pimarane diterpenes; Cat’s whisker; anti-diabetes Lamiaceae; Orthosiphon stamineus; Pimarane diterpenes; Cat’s whisker; anti-diabetes
Show Figures

Graphical abstract

MDPI and ACS Style

Nguyen, P.H.; Tuan, H.N.; Hoang, D.T.; Vu, Q.T.; Pham, M.Q.; Tran, M.H.; To, D.C. Glucose Uptake Stimulatory and PTP1B Inhibitory Activities of Pimarane Diterpenes from Orthosiphon stamineus Benth. Biomolecules 2019, 9, 859.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop