Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)
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Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, University Mohammed the First, P.O. Box 524, 60000 Oujda, Morocco
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Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
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Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Vito Verardo
Biomolecules 2022, 12(1), 20; https://doi.org/10.3390/biom12010020
Received: 28 November 2021
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Revised: 16 December 2021
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Accepted: 20 December 2021
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Published: 23 December 2021
(This article belongs to the Topic Compounds with Medicinal Value)
Medicinal and aromatic plants are mainly characterized by the presence of different bioactive compounds which exhibit various therapeutic activities. In order to investigate the different pharmacological properties of different Nigella sativa extracts, a multitude of research articles published in the period between 2019 and 2021 were obtained from different databases (Scopus, Science Direct, PubMed, and Web of Science), and then explored and analyzed. The analysis of the collected articles allows us to classify the phytochemicals and the pharmacological activities through their underlying molecular mechanisms, as well as to explore the pharmacological activities exhibited by several identified compounds in Nigella sativa which allow a better understanding, and better elucidation, of the bioactive compounds responsible for the pharmacological effects. Also shown are the existence of other bioactive compounds that are still unexplored and could be of great interest. This review could be taken as a guide for future studies in the field.
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Keywords:
Nigella sativa; thymoquinone; oil; organic extracts; pharmacological properties
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MDPI and ACS Style
Dalli, M.; Bekkouch, O.; Azizi, S.-e.; Azghar, A.; Gseyra, N.; Kim, B. Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021). Biomolecules 2022, 12, 20. https://doi.org/10.3390/biom12010020
AMA Style
Dalli M, Bekkouch O, Azizi S-e, Azghar A, Gseyra N, Kim B. Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021). Biomolecules. 2022; 12(1):20. https://doi.org/10.3390/biom12010020
Chicago/Turabian StyleDalli, Mohammed, Oussama Bekkouch, Salah-eddine Azizi, Ali Azghar, Nadia Gseyra, and Bonglee Kim. 2022. "Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review (2019–2021)" Biomolecules 12, no. 1: 20. https://doi.org/10.3390/biom12010020
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