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Biomolecules, Volume 12, Issue 1

January 2022 - 146 articles

Cover Story: The molecular scaffold manipulation of phenols/polyphenols by the insertion of S/Se/Te-containing functionalities or by the replacement of oxygen atoms with heavier chalcogens is a currently pursued approach to boost or modulate their properties, with particular reference to their antioxidant properties. These latter properties are evaluated by conventional chemical assays and different model systems in association with computational approaches. Overall, the studies that are illustrated in this review contribute to the effort of drawing a well-defined picture of the mode of action of polyphenols and how their activity is affected by heavier chalcogens from the viewpoint of chemical mechanisms, an issue that is not frequently addressed in discussions regarding natural polyphenol activity. View this paper
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Articles (146)

  • Review
  • Open Access
22 Citations
5,136 Views
10 Pages

The Role of the lncRNA MALAT1 in Neuroprotection against Hypoxic/Ischemic Injury

  • Liping Wang,
  • Sijie Li,
  • Sara Saymuah Stone,
  • Na Liu,
  • Kerui Gong,
  • Changhong Ren,
  • Kai Sun,
  • Chunyang Zhang and
  • Guo Shao

17 January 2022

Hypoxic and ischemic brain injury can cause neurological disability and mortality, and has become a serious public health problem worldwide. Long-chain non-coding RNAs are involved in the regulation of many diseases. Metastasis-related lung adenocarc...

  • Review
  • Open Access
19 Citations
6,185 Views
17 Pages

Chemistry and Biochemistry Aspects of the 4-Hydroxy-2,3-trans-nonenal

  • Anna Bilska-Wilkosz,
  • Małgorzata Iciek and
  • Magdalena Górny

16 January 2022

4-hydroxy-2,3-trans-nonenal (C9H16O2), also known as 4-hydroxy-2E-nonenal (C9H16O2; HNE) is an α,β-unsaturated hydroxyalkenal. HNE is a major aldehyde, formed in the peroxidation process of ω-6 polyunsaturated fatty acids (ω-6...

  • Article
  • Open Access
26 Citations
3,728 Views
17 Pages

Fatty Acid Composition and Contents of Fish of Genus Salvelinus from Natural Ecosystems and Aquaculture

  • Michail I. Gladyshev,
  • Alexander A. Makhrov,
  • Ilia V. Baydarov,
  • Stanislava S. Safonova,
  • Viktor M. Golod,
  • Sergey S. Alekseyev,
  • Larisa A. Glushchenko,
  • Anastasia E. Rudchenko,
  • Vladimir A. Karpov and
  • Nadezhda N. Sushchik

16 January 2022

Fatty acids (FA) of muscle tissue of Salvelinus species and its forms, S. alpinus, S. boganidae, S. drjagini, and S. fontinalis, from six Russian lakes and two aquacultures, were analyzed. Considerable variations in FA compositions and contents were...

  • Review
  • Open Access
35 Citations
4,595 Views
20 Pages

16 January 2022

α-Synuclein (αS) is a small, unstructured, presynaptic protein expressed in the brain. Its aggregated form is a major component of Lewy bodies, the large proteinaceous deposits in Parkinson’s disease. The closely related protein, &b...

  • Review
  • Open Access
41 Citations
5,543 Views
16 Pages

Antioxidant Roles of SGLT2 Inhibitors in the Kidney

  • Carmen Llorens-Cebrià,
  • Mireia Molina-Van den Bosch,
  • Ander Vergara,
  • Conxita Jacobs-Cachá and
  • Maria José Soler

16 January 2022

The reduction-oxidation (redox) system consists of the coupling and coordination of various electron gradients that are generated thanks to serial reduction-oxidation enzymatic reactions. These reactions happen in every cell and produce radical oxida...

  • Review
  • Open Access
37 Citations
7,561 Views
18 Pages

Smart Bioinks for the Printing of Human Tissue Models

  • Zeina Maan,
  • Nadia Z. Masri and
  • Stephanie M. Willerth

15 January 2022

3D bioprinting has tremendous potential to revolutionize the field of regenerative medicine by automating the process of tissue engineering. A significant number of new and advanced bioprinting technologies have been developed in recent years, enabli...

  • Article
  • Open Access
17 Citations
4,504 Views
17 Pages

How Far Are We from the Completion of the Human Protein Interactome Reconstruction?

  • Georgios N. Dimitrakopoulos,
  • Maria I. Klapa and
  • Nicholas K. Moschonas

15 January 2022

After more than fifteen years from the first high-throughput experiments for human protein–protein interaction (PPI) detection, we are still wondering how close the completion of the genome-scale human PPI network reconstruction is, what needs...

  • Article
  • Open Access
10 Citations
3,754 Views
14 Pages

Whole-Cell Display of Phosphotransferase in Escherichia coli for High-Efficiency Extracellular ATP Production

  • Shuai Zhao,
  • Guoli Yang,
  • Xiaochen Xie,
  • Guangbo Yan,
  • Fei Wang,
  • Wanping Chen and
  • Lixin Ma

15 January 2022

Adenosine triphosphate (ATP), as a universal energy currency, takes a central role in many biochemical reactions with potential for the synthesis of numerous high-value products. However, the high cost of ATP limits industrial ATP-dependent enzyme-ca...

  • Systematic Review
  • Open Access
45 Citations
5,372 Views
30 Pages

Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis—A Systematic Review

  • Aniela Brodzikowska,
  • Monika Ciechanowska,
  • Michał Kopka,
  • Albert Stachura and
  • Paweł K. Włodarski

15 January 2022

Lipopolysaccharide (LPS) is widely used for induction of inflammation in various human tissues, including dental pulp. The purpose of this study was to summarize current medical literature focusing on (1) cell types used by researchers to simulate de...

  • Article
  • Open Access
11 Citations
3,328 Views
17 Pages

Association of Angio-LncRNAs MIAT rs1061540/MALAT1 rs3200401 Molecular Variants with Gensini Score in Coronary Artery Disease Patients Undergoing Angiography

  • Mohamed Y. Elwazir,
  • Mohammad H. Hussein,
  • Eman A. Toraih,
  • Essam Al Ageeli,
  • Safya E. Esmaeel,
  • Manal S. Fawzy and
  • Salwa Faisal

15 January 2022

Long non-coding RNAs (lncRNAs) have emerged as essential biomolecules with variable diagnostic and/or prognostic utility in several diseases, including coronary artery disease (CAD). We aimed for the first time to investigate the potential associatio...

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Biomolecules - ISSN 2218-273X