Special Issue "Gaseous Transmitters and Cardiovascular System"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (31 January 2021).

Special Issue Editor

Dr. Sona Cacanyiova
E-Mail Website
Guest Editor
Slovak Academy of Sciences, Bratislava, Slovakia
Interests: physiology and patophysiology of cardiovascular system aimed on function of endothelium, smooth muscle cells and nerve regulation; investigation of signal pathways enagaged to the etiopathology of hypertension and metabolic syndrome, nitric oxide and hydrogen sulfide predominantly; evaluation of the activity of conduit and resistance arteries using functional methods in vivo and in vitro in animal experimental models as well as in samples of patients

Special Issue Information

Dear Colleagues,

In the last two decades, a large body of experimental evidence has demonstrated that gaseous transmitters, which have signaled the end of the traditional concept of intercellular signalization, might play a crucial role in cardiovascular system regulation. Unlike classical messengers, they are not readily stored in vesicular structures, are re-synthesized as needed, and affect cellular metabolism in a more immediate fashion. Hydrogen sulfide (H2S) and carbon monoxide (CO), next to nitric oxide (NO), are the most recently studied endogenous gaseous mediators, and their role in the regulation of cardiovascular system physiology and pathophysiology has been emphasized.

This Special Issue is focused on the role of NO, H2S, and CO in the regulation of the cardiovascular system under both normal and pathological conditions. All three gaseous messengers synchronize complicated processes, such as blood pressure regulation, vessel tone modulation, neurotransmission, angiogenesis, and endothelial and heart function. Moreover, a possible crosstalk among NO, H2S, and CO produced endogenously or released from chemical donors, as well as their potential therapeutic applications, has attracted great attention from many fields of biomedicine. This Special Issue welcomes original research articles and reviews on all aspects of the molecular mechanisms and functional action of gaseous transmitters as well as those on the effectiveness of their donors in experimental or clinical studies.

Dr. Sona Cacanyiova
Guest Editor

Manuscript Submission Information

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Keywords

  • Gaseous transmitters
  • Nitric oxide
  • Hydrogen sulfide
  • Carbon monoxide
  • Cardiovascular system

Published Papers (3 papers)

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Research

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Article
Cardiovascular “Patterns” of H2S and SSNO-Mix Evaluated from 35 Rat Hemodynamic Parameters
Biomolecules 2021, 11(2), 293; https://doi.org/10.3390/biom11020293 - 16 Feb 2021
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Abstract
This work is based on the hypothesis that it is possible to characterize the cardiovascular system just from the detailed shape of the arterial pulse waveform (APW). Since H2S, NO donor S-nitrosoglutathione (GSNO) and their H2S/GSNO products (SSNO [...] Read more.
This work is based on the hypothesis that it is possible to characterize the cardiovascular system just from the detailed shape of the arterial pulse waveform (APW). Since H2S, NO donor S-nitrosoglutathione (GSNO) and their H2S/GSNO products (SSNO-mix) have numerous biological actions, we aimed to compare their effects on APW and to find characteristic “patterns” of their actions. The right jugular vein of anesthetized rats was cannulated for i.v. administration of the compounds. The left carotid artery was cannulated to detect APW. From APW, 35 hemodynamic parameters (HPs) were evaluated. H2S transiently influenced all 35 HPs and from their cross-relationships to systolic blood pressure “patterns” and direct/indirect signaling pathways of the H2S effect were proposed. The observed “patterns” were mostly different from the published ones for GSNO. Effect of SSNO-mix (≤32 nmol kg−1) on blood pressure in the presence or absence of a nitric oxide synthase inhibitor (L-NAME) was minor in comparison to GSNO, suggesting that the formation of SSNO-mix in blood diminished the hemodynamic effect of NO. The observed time-dependent changes of 35 HPs, their cross-relationships and non-hysteresis/hysteresis profiles may serve as “patterns” for the conditions of a transient decrease/increase of blood pressure caused by H2S. Full article
(This article belongs to the Special Issue Gaseous Transmitters and Cardiovascular System)
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Article
The Vasoactive Role of Perivascular Adipose Tissue and the Sulfide Signaling Pathway in a Nonobese Model of Metabolic Syndrome
Biomolecules 2021, 11(1), 108; https://doi.org/10.3390/biom11010108 - 15 Jan 2021
Cited by 1 | Viewed by 804
Abstract
The aim of this study was to evaluate the mutual relationship among perivascular adipose tissue (PVAT) and endogenous and exogenous H2S in vasoactive responses of isolated arteries from adult normotensive (Wistar) rats and hypertriglyceridemic (HTG) rats, which are a nonobese model [...] Read more.
The aim of this study was to evaluate the mutual relationship among perivascular adipose tissue (PVAT) and endogenous and exogenous H2S in vasoactive responses of isolated arteries from adult normotensive (Wistar) rats and hypertriglyceridemic (HTG) rats, which are a nonobese model of metabolic syndrome. In HTG rats, mild hypertension was associated with glucose intolerance, dyslipidemia, increased amount of retroperitoneal fat, increased arterial contractility, and endothelial dysfunction associated with arterial wall injury, which was accompanied by decreased nitric oxide (NO)-synthase activity, increased expression of H2S producing enzyme, and an altered oxidative state. In HTG, endogenous H2S participated in the inhibition of endothelium-dependent vasorelaxation regardless of PVAT presence; on the other hand, aortas with preserved PVAT revealed a stronger anticontractile effect mediated at least partially by H2S. Although we observed a higher vasorelaxation induced by exogenous H2S donor in HTG rats than in Wistar rats, intact PVAT subtilized this effect. We demonstrate that, in HTG rats, endogenous H2S could manifest a dual effect depending on the type of triggered signaling pathway. H2S within the arterial wall contributes to endothelial dysfunction. On the other hand, PVAT of HTG is endowed with compensatory vasoactive mechanisms, which include stronger anti-contractile action of H2S. Nevertheless, the possible negative impact of PVAT during hypertriglyceridemia on the activity of exogenous H2S donors needs to be taken into consideration. Full article
(This article belongs to the Special Issue Gaseous Transmitters and Cardiovascular System)
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Review

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Review
The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone
Biomolecules 2020, 10(12), 1685; https://doi.org/10.3390/biom10121685 - 16 Dec 2020
Viewed by 744
Abstract
A better understanding of the regulation of cerebrovascular circulation is of great importance because stroke and other cerebrovascular diseases represent a major concern in healthcare leading to millions of deaths yearly. The circulation of the central nervous system is regulated in a highly [...] Read more.
A better understanding of the regulation of cerebrovascular circulation is of great importance because stroke and other cerebrovascular diseases represent a major concern in healthcare leading to millions of deaths yearly. The circulation of the central nervous system is regulated in a highly complex manner involving many local factors and hydrogen sulfide (H2S) is emerging as one such possible factor. Several lines of evidence support that H2S takes part in the regulation of vascular tone. Examinations using either exogenous treatment with H2S donor molecules or alterations to the enzymes that are endogenously producing this molecule revealed numerous important findings about its physiological and pathophysiological role. The great majority of these studies were performed on vessel segments derived from the systemic circulation but there are important observations made using cerebral vessels as well. The findings of these experimental works indicate that H2S is having a complex, pleiotropic effect on the vascular wall not only in the systemic circulation but in the cerebrovascular region as well. In this review, we summarize the most important experimental findings related to the potential role of H2S in the cerebral circulation. Full article
(This article belongs to the Special Issue Gaseous Transmitters and Cardiovascular System)
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