Special Issue "Leptin and Beyond: Actors in Cancer"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 15 April 2020.

Special Issue Editors

Dr. Ines Barone
E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Interests: tumor microenvironment; adipokines; breast cancer; nuclear receptors; endocrine resistance; endocrine-related cancers
Dr. Cinzia Giordano
E-Mail Website
Guest Editor
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy
Interests: breast cancer; microenvironment; leptin; exosomes; endocrine resistance

Special Issue Information

Dear Colleagues,

We are celebrating the 25th anniversary of the discovery of the adipocyte-derived factor leptin, a multifunctional polypetidic molecule encoded by the ob gene. First known as an essential regulator of appetite and energy balance homeostasis, this adipokine has been recognized to play a role in a wide range of additional biological peripheral activities, including carcinogenesis. During the last few decades, there has been an explosion of research highlighting how the leptin/leptin receptor axis may affect many aspects of cancer biology, from initiation and primary tumor growth to metastatic progression. A plethora of studies have also led to the identification of leptin interaction with multiple oncogenic pathways, including growth factor, estrogen, Notch, and inflammatory cytokine signaling.

In this Special Issue, we welcome original research articles, as well as review articles, related to the role of leptin and its associated networks in cancer to provide readers with novel insights on the compelling mechanistic and clinical perspectives in this attractive area.

Dr. Ines Barone
Dr. Cinzia Giordano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • leptin
  • cytokines
  • growth factors
  • cancer
  • obesity
  • tumor microenvironment

Published Papers

This special issue is now open for submission.
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