Leptin and Beyond: Actors in Cancer

Dear Colleagues,

We are celebrating the 25^th anniversary of the discovery of the adipocyte-derived factor leptin, a multifunctional polypetidic molecule encoded by the ob gene. First known as an essential regulator of appetite and energy balance homeostasis, this adipokine has been recognized to play a role in a wide range of additional biological peripheral activities, including carcinogenesis. During the last few decades, there has been an explosion of research highlighting how the leptin/leptin receptor axis may affect many aspects of cancer biology, from initiation and primary tumor growth to metastatic progression. A plethora of studies have also led to the identification of leptin interaction with multiple oncogenic pathways, including growth factor, estrogen, Notch, and inflammatory cytokine signaling.

In this Special Issue, we welcome original research articles, as well as review articles, related to the role of leptin and its associated networks in cancer to provide readers with novel insights on the compelling mechanistic and clinical perspectives in this attractive area.

Dr. Ines Barone
Dr. Cinzia Giordano
Guest Editors

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