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Metabolites, Volume 6, Issue 1

March 2016 - 11 articles

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Articles (11)

  • Review
  • Open Access
38 Citations
7,363 Views
22 Pages

According to World Health Organization (WHO) estimates, cancer is responsible for more deaths than all coronary heart disease or stroke worldwide, serving as a major public health threat around the world. High resolution magic angle spinning (HRMAS)...

  • Review
  • Open Access
117 Citations
17,210 Views
17 Pages

Cancer Metabolomics and the Human Metabolome Database

  • David S. Wishart,
  • Rupasri Mandal,
  • Avalyn Stanislaus and
  • Miguel Ramirez-Gaona

The application of metabolomics towards cancer research has led to a renewed appreciation of metabolism in cancer development and progression. It has also led to the discovery of metabolite cancer biomarkers and the identification of a number of nove...

  • Article
  • Open Access
35 Citations
7,548 Views
16 Pages

Metabolomic Profiling of Submaximal Exercise at a Standardised Relative Intensity in Healthy Adults

  • Ali Muhsen Ali,
  • Mia Burleigh,
  • Evangelia Daskalaki,
  • Tong Zhang,
  • Chris Easton and
  • David G. Watson

26 February 2016

Ten physically active subjects underwent two cycling exercise trials. In the first, aerobic capacity (VO2max) was determined and the second was a 45 min submaximal exercise test. Urine samples were collected separately the day before (day 1) , the da...

  • Communication
  • Open Access
55 Citations
11,408 Views
7 Pages

The Time Is Right to Focus on Model Organism Metabolomes

  • Arthur S. Edison,
  • Robert D. Hall,
  • Christophe Junot,
  • Peter D. Karp,
  • Irwin J. Kurland,
  • Robert Mistrik,
  • Laura K. Reed,
  • Kazuki Saito,
  • Reza M. Salek and
  • Christoph Steinbeck
  • + 2 authors

15 February 2016

Model organisms are an essential component of biological and biomedical research that can be used to study specific biological processes. These organisms are in part selected for facile experimental study. However, just as importantly, intensive stud...

  • Article
  • Open Access
14 Citations
7,435 Views
10 Pages

Visualization of Microfloral Metabolism for Marine Waste Recycling

  • Tatsuki Ogura,
  • Reona Hoshino,
  • Yasuhiro Date and
  • Jun Kikuchi

27 January 2016

Marine biomass including fishery products are precious protein resources for human foods and are an alternative to livestock animals in order to reduce the virtual water problem. However, a large amount of marine waste can be generated from fishery p...

  • Article
  • Open Access
26 Citations
9,407 Views
14 Pages

Development of an Optimized Protocol for NMR Metabolomics Studies of Human Colon Cancer Cell Lines and First Insight from Testing of the Protocol Using DNA G-Quadruplex Ligands as Novel Anti-Cancer Drugs

  • Ilaria Lauri,
  • Francesco Savorani,
  • Nunzia Iaccarino,
  • Pasquale Zizza,
  • Luigi Michele Pavone,
  • Ettore Novellino,
  • Søren Balling Engelsen and
  • Antonio Randazzo

15 January 2016

The study of cell lines by nuclear magnetic resonance (NMR) spectroscopy metabolomics represents a powerful tool to understand how the local metabolism and biochemical pathways are influenced by external or internal stimuli. In particular, the use of...

  • Review
  • Open Access
68 Citations
8,261 Views
11 Pages

15 January 2016

Metabolism is a chemical process used by cells to transform food-derived nutrients, such as proteins, carbohydrates and fats, into chemical and thermal energy. Whenever an alteration of this process occurs, the chemical balance within the cells is im...

  • Communication
  • Open Access
15 Citations
6,375 Views
10 Pages

Application of Pre-Column Labeling Liquid Chromatography for Canine Plasma-Free Amino Acid Analysis

  • Kazuo Azuma,
  • Yoshiko Hirao,
  • Yoshihiro Hayakawa,
  • Yusuke Murahata,
  • Tomohiro Osaki,
  • Takeshi Tsuka,
  • Tomohiro Imagawa,
  • Yoshiharu Okamoto and
  • Norihiko Ito

12 January 2016

Plasma-free amino acid (PFAA) levels are a useful metric for diagnosing cancer and providing a prognosis. However, the use of analysis of PFAA levels has been limited in the veterinary medicine field. We addressed the application of liquid chromatogr...

  • Article
  • Open Access
49 Citations
14,258 Views
18 Pages

Using Molecular Networking for Microbial Secondary Metabolite Bioprospecting

  • Kevin Purves,
  • Lynsey Macintyre,
  • Debra Brennan,
  • Guðmundur Ó. Hreggviðsson,
  • Eva Kuttner,
  • Margrét E. Ásgeirsdóttir,
  • Louise C. Young,
  • David H. Green,
  • Ruangelie Edrada-Ebel and
  • Katherine R. Duncan

The oceans represent an understudied resource for the isolation of bacteria with the potential to produce novel secondary metabolites. In particular, actinomyces are well known to produce chemically diverse metabolites with a wide range of biological...

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Metabolites - ISSN 2218-1989