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Diseases, Volume 6, Issue 2

June 2018 - 30 articles

Cover Story: Aspergillosis of the central nervous system is an uncommon complication following neurosurgical interventions. The diagnosis is challenging due the lack of highly sensitive methods to isolate Aspergillus from surgical sites. We report a case of post-surgical aspergillosis that occurred after the resection of acoustic neuroma. The diagnosis was achieved by histopathology and polymerase chain reaction (PCR) in brain tissue. The patient was successfully treated with voriconazole. We advocate the use of molecular techniques to improve the diagnostic yield of this condition. View this paper.
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Articles (30)

  • Feature Paper
  • Communication
  • Open Access
27 Citations
7,326 Views
9 Pages

Hepatitis C in Pregnancy

  • Pratima Dibba,
  • Rosann Cholankeril,
  • Andrew A. Li,
  • Meera Patel,
  • Mariam Fayek,
  • Christy Dibble,
  • Nnenna Okpara,
  • Autumn Hines and
  • Aijaz Ahmed

The prevalence of hepatitis C in pregnancy is as high as 3.6% in large cohorts. The prevalence of hepatitis C acquired by vertical transmission is 0.2% to 0.4% in the United States and Europe. Although screening is not recommended in the absence of c...

  • Article
  • Open Access
44 Citations
10,092 Views
14 Pages

This study set out to evaluate self-medicated antibiotics and knowledge of antibiotic resistance among undergraduate students and community members in northern Nigeria. Antibiotic consumption pattern, source of prescription, illnesses commonly treate...

  • Feature Paper
  • Case Report
  • Open Access
22 Citations
7,668 Views
8 Pages

Use of Leukocyte Platelet (L-PRF) Rich Fibrin in Diabetic Foot Ulcer with Osteomyelitis (Three Clinical Cases Report)

  • Alessandro Crisci,
  • Giuseppe Marotta,
  • Anna Licito,
  • Edda Serra,
  • Giulio Benincasa and
  • Michela Crisci

In this study, the use of fibrin rich in leukocytes and platelets (L-PRF) was explored to heal osteomyelitis ulcers in a diabetic foot. The goal was to standardize the utilization of L-PRF in patients with osteomyelitis to direct it for healing. L-PR...

  • Article
  • Open Access
13 Citations
4,746 Views
7 Pages

Levels of Soluble Endothelium Adhesion Molecules and Complications among Sickle Cell Disease Patients in Ghana

  • Charles Antwi-Boasiako,
  • Eric S. Donkor,
  • Fredericka Sey,
  • Bartholomew Dzudzor,
  • Gifty B. Dankwah,
  • Kate H. Otu,
  • Alfred Doku,
  • Campbell A. Dale and
  • Ivy Ekem

Background: Soluble adhesion molecules are involved in the gathering and joining of inflammatory cells to vascular endothelium. Therefore, they serve as potential markers of endothelial dysfunction in vascular diseases including sickle cell disease (...

  • Feature Paper
  • Review
  • Open Access
25 Citations
6,158 Views
8 Pages

Update Treatment for HBV Infection and Persistent Risk for Hepatocellular Carcinoma: Prospect for an HBV Cure

  • Joseph Yoo,
  • Hie-Won Hann,
  • Robert Coben,
  • Mitchell Conn and
  • Anthony J. DiMarino

Since the discovery of the hepatitis B virus (HBV) by Blumberg et al. in 1965, its genome, sequence, epidemiology, and hepatocarcinogenesis have been elucidated. Globally, hepatitis B virus (HBV) is still responsible for the majority of hepatocellula...

  • Feature Paper
  • Review
  • Open Access
70 Citations
11,318 Views
13 Pages

Implications of PI3K/AKT/PTEN Signaling on Superoxide Dismutases Expression and in the Pathogenesis of Alzheimer’s Disease

  • Satoru Matsuda,
  • Yukie Nakagawa,
  • Ai Tsuji,
  • Yasuko Kitagishi,
  • Atsuko Nakanishi and
  • Toshiyuki Murai

Alzheimer’s disease is a neurodegenerative sickness, where the speed of personal disease progression differs prominently due to genetic and environmental factors such as life style. Alzheimer’s disease is described by the construction of...

  • Article
  • Open Access
12 Citations
6,019 Views
12 Pages

The Voice of the Heart: Vowel-Like Sound in Pulmonary Artery Hypertension

  • Mohamed Elgendi,
  • Prashant Bobhate,
  • Shreepal Jain,
  • Long Guo,
  • Jennifer Rutledge,
  • Yashu Coe,
  • Roger Zemp,
  • Dale Schuurmans and
  • Ian Adatia

Increased blood pressure in the pulmonary artery is referred to as pulmonary hypertension and often is linked to loud pulmonic valve closures. For the purpose of this paper, it was hypothesized that pulmonary circulation vibrations will create sounds...

  • Case Report
  • Open Access
4 Citations
5,275 Views
8 Pages

ERBB1- and ERBB2-Positive Medullary Thyroid Carcinoma: A Case Report

  • Michele Minuto,
  • Emanuela Varaldo,
  • Gianluca Marcocci,
  • Amleto De Santanna,
  • Ermanno Ciccone and
  • Katia Cortese

Medullary thyroid carcinomas (MTCs) are rare thyroid tumors occurring in both sporadic and hereditary forms, whose pathogenesis is related to RET proto-oncogene alterations. MTCs originate from parafollicular cells, which produce calcitonin that repr...

  • Article
  • Open Access
4 Citations
4,318 Views
12 Pages

Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment

  • Ismael San Mauro Martín,
  • Javier Andrés Blumenfeld Olivares,
  • Eva Pérez Arruche,
  • Esperanza Arce Delgado,
  • María José Ciudad Cabañas,
  • Elena Garicano Vilar and
  • Luis Collado Yurrita

Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce...

  • Commentary
  • Open Access
12 Citations
16,758 Views
9 Pages

The brain and the gut are connected from early fetal life. The mother’s exposure to microbial molecules is thought to exert in utero developmental effects on the fetus. These effects could importantly underpin the groundwork for subsequent pathophysi...

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Diseases - ISSN 2079-9721