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Article

Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms

1
Gragem Co., Ltd., Incheon 21999, Korea
2
Department of Biotechnology, The University of Suwon, Hwaseong 18323, Korea
*
Authors to whom correspondence should be addressed.
Two authors contributed equally to this work.
Academic Editor: Kazuhisa Maeda
Cosmetics 2021, 8(3), 63; https://doi.org/10.3390/cosmetics8030063
Received: 21 March 2021 / Revised: 28 April 2021 / Accepted: 21 June 2021 / Published: 30 June 2021
Sulforaphane increases the expression of the dihydrotestosterone (DHT)-degrading enzyme, 3α-hydroxysteroid dehydrogenase (3α-HSD) in the liver, which accelerates DHT degradation, thereby inhibiting hair loss in the animal model. In this study, we elucidated its underlying mechanism and demonstrated that sulforaphane has hair loss inhibitory functions in RAW264.7 macrophage cells and Hepa1c1c7 cells at the cellular and gene levels. The gene expression level of an isoform of 3α-HSD, Akr1c2, increased in a dose-dependent manner when these cells were treated with sulforaphane, but there were no significant differences at the gene levels of Akr1c2 and Dhrs9 for the negative control mixture of biotin, dexpanthenol, and L-menthol. These studies indicated that sulforaphane is involved in regulating the gene expression of Akr1c2. To further determine whether this hair product has effects on alleviating hair loss symptoms, clinical trials were also conducted for 18 weeks. We performed a visual evaluation of the parietal and frontal lines of 23 patients before and after using the product, and then calculated the total number of hairs. This clinical study showed that the parietal lines and bangs visually improved and the number of hairs increased by 6.71% from before using the test product to 18 weeks after using the test product. Taken together, these cellular and clinical studies strongly suggest that sulforaphane may be an active ingredient that significantly alleviates hair loss symptoms. View Full-Text
Keywords: sulforaphane; hair loss; cosmetic ingredient; functional cosmetics sulforaphane; hair loss; cosmetic ingredient; functional cosmetics
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MDPI and ACS Style

Park, Y.; Choi, K.; Kim, H.; Lee, J.; Park, G.; Kim, J. Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms. Cosmetics 2021, 8, 63. https://doi.org/10.3390/cosmetics8030063

AMA Style

Park Y, Choi K, Kim H, Lee J, Park G, Kim J. Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms. Cosmetics. 2021; 8(3):63. https://doi.org/10.3390/cosmetics8030063

Chicago/Turabian Style

Park, Youngkum, Kanghyun Choi, Hyoseon Kim, Jihye Lee, Gyeryeol Park, and Junehyun Kim. 2021. "Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms" Cosmetics 8, no. 3: 63. https://doi.org/10.3390/cosmetics8030063

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